Clinical trials: Ischemic Postconditioning
Myocardial Infarction
Ischemic Postconditioning on Microvascular Obstruction in Reperfused Myocardial Infarction
Objectives. We will evaluate the effect of ischemic postconditioning (PCON) on microvascular obstruction (MVO) in patients with a first ST-segment elevation myocardial infarction (STEMI) treated with primary angioplasty.
- Trial name
- POSTRE (NCT01898546)
- Testing
- Primary angioplasty, Postconditioning
- Where
- Spain
- Volunteers
- 243 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Acute Myocardial Infarction
Phase II Clinical Trial to Evaluate the Benefits of Postconditioning in ST-Elevation Myocardial Infarction (STEMI)
This study will evaluate change in heart muscle function from baseline to three months and twelve months in participants who present with a heart attack and a completely occluded coronary artery.
- Trial name
- NCT01324453
- Testing
- Post Conditioning + Primary PCI, Standard Primary PCI
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Minneapolis Heart Institute Foundation
Ischemia-reperfusion Injury
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery
Background. Cardiopulmonary bypass in on-pump cardiac surgery (OPCS) can have harmful effects by ischemia-reperfusion. No data about the effects of remote ischemic postconditioning (RIP) in hypoxia-inducible factor-1 alpha…
- Trial name
- NCT04284592
- Testing
- Remote ischemic post-conditioning (RIP)
- Volunteers
- 70 people
- Sponsor
- José García de la Asunción
Heart Valve Diseases
Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients.
- Trial name
- NCT01427621
- Testing
- remote ischemic pre and postconditioning (RIPC)
- Volunteers
- 54 people
- Sponsor
- Yonsei University
Ischemic Postconditioning, Carotid Surgery
Ischemic Postconditioning in Carotid Surgery
Analyzing changes in cerebral oximetry, transcranial Doppler and biomarkers of neuronal ischemic injury and blood-brain barrier integrity assessing the safety and efficacy of ischemic postconditioning in carotid surgery (IPCT).
- Conditions
- Ischemic Postconditioning, Carotid Surgery, Stroke, Carotid Artery Diseases
- Trial name
- BRAIN-SAVE (NCT06359756)
- Testing
- Ischemic postconditioning in carotid surgery, Eversion Carotid Endarterectomy
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- Institute for Cardiovascular Diseases Dedinje
Out-Of-Hospital Cardiac Arrest
Effect of Remote Ischemic Post-conditioning on Out-of-hospital Cardiac Arrest
Ischemia-reperfusion leads to mitochondrial injury, ion-pump injury, cell membrane damage, cytotoxic edema, and excessive oxygen free radical formation, and eventually destroys cells.
- Trial name
- NCT03093948
- Testing
- Remote ischemic post-conditioning
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Chonnam National University Hospital
Myocardial Reperfusion Injury, Myocardial Ischemia
Remote Postconditioning in Patients With Acute Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention (PCI)
Background: Experimental studies suggest that remote limb ischaemic postconditioning (RemPostCon) can reduce infarct size in pigs.
- Conditions
- Myocardial Reperfusion Injury, Myocardial Ischemia, Myocardial Infarction
- Trial name
- RemPostCon (NCT00865722)
- Testing
- Remote Postconditioning
- Where
- 2 sites in Italy
- Volunteers
- 96 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Moyamoya Disease, Remote Ischemic Preconditioning
Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome
In the present study, we evaluated whether RIPC with RIPostC reduce the major neurocomplication in patients undergoing STA-MCA anastomosis.
- Trial name
- NCT03072914
- Testing
- RIPC with RIPostC
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Cardiopulmonary Bypass, Ischemic Postconditioning
Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement
1. Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral). 2.
- Trial name
- NCT01804283
- Testing
- ischemic postconditioning, double valve replacement, heart-lung machine
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Central South University
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning (SCRIP) Trial
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning in patient undergoing coronary angioplasty.
- Trial name
- SCRIP (NCT02649309)
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 370 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Myocardial Reperfusion Injury
POSTconditioning During Coronary Angioplasty in Acute Myocardial Infarction Study
The POST-conditioning during coronary angioplasty in Acute Myocardial Infarction (POST-AMI) trial will evaluate the usefulness of postconditioning in limiting infarct size and microvascular damage during the early and late phases…
- Trial name
- POST-AMI (NCT01004289)
- Testing
- Postconditioning, Primary angioplasty and stenting without additional intervention
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- University of Padova
Acute Myocardial Infarction
Positive Effect of Ischemic Postconditioning During Acute Myocardial Infarction
The purpose of this study is to determine whether brief periods of ischemia performed just at the time of reperfusion -postconditioning- can reduce coronary endothelial dysfunction and infarct size in humans
- Trial name
- NCT00333320
- Testing
- postconditioning, Control group
- Where
- France
- Volunteers
- 46 people
- Sponsor
- French Cardiology Society
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning for prevention of contrast-induced acute kidney injury in…
- Trial name
- NCT02729155
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 596 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Coronary Artery Disease, Myocardial Infarction
Reduction in Infarct Size by Remote Per-postconditioning in Patients With ST-elevation Myocardial Infarction
Trial objective: To test the hypothesis that remote per-postconditioning in connection with primary PCI will reduce myocardial infarct size patients with STEMI.
- Trial name
- RECOND (NCT02021760)
- Testing
- Primary Percutaneous Coronary Intervention
- Where
- 3 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- John Pernow
Myocardial Reperfusion Injury
Delayed Postconditioning
The investigators previously reported that angioplasty postconditioning reduces infarct size (cardiac enzyme release) in STEMI patients with a fully occluded coronary artery at hospital admission.
- Trial name
- PRIME (NCT01483755)
- Testing
- Postconditioning, Percutaneaous intervention
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- Hospices Civils de Lyon
Acute Myocardial Infarction With ST Elevation
Analysis of the Efficacy of Cardiac Ischemic Postconditioning With New Clinical End-points Using Novel Biomarkers
The aim of the present study was to investigate the efficacy of ischemic postconditioning in acute myocardial infarction patients. The safety of patients enrolled in the study was ensured during the entire study.
- Trial name
- NCT04824716
- Testing
- Postconditioning, Percutaneous coronary intervention
- Where
- 3 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Peter Ferdinandy
Myocardial Infarction
Remote Ischemic Preconditioning Combined to Local Ischemic Postconditioning in Acute Myocardial Infarction
RIRE-1 is a randomized, open-label with blinded end-point study that will test the hypothesis that remote ischemic preconditioning initiated at the time of the admission in the cathlab reduces infarct size in ST-segment elevation…
- Trial name
- RIRE-1 (NCT01390142)
- Testing
- Control, RIPer, RIPer + IPost
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Myocardial Infarction
Postconditioning in Primary PCI and Direct Stenting
To determine the safety and efficacy of 2 vs 4 cycles of postconditioning method during primary PCI and direct stenting in acute MI, and to compared to primary PCI and direct stenting without the postconditioning.
- Trial name
- NCT00351247
- Testing
- Postconditioning
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Sheba Medical Center
Kidney Transplantation, Ischemic Reperfusion Injury
The Effect of Remote Postconditioning on Graft Function in Patients Undergoing Living-related Kidney Transplantation
The purpose of this study is to investigate whether upper limb ischemic postconditioning can improve renal function and decrease ischemic-reperfusion injury in patients undergoing living donor kidney transplantation.
- Conditions
- Kidney Transplantation, Ischemic Reperfusion Injury, Remote Ischemic Postconditioning
- Trial name
- NCT01363687
- Testing
- remote ischemic postconditioning
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Cardiovascular Disease, Ischemia-reperfusion Injury
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
To adjust our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemia reperfusion damage in elderly and patients.
- Conditions
- Cardiovascular Disease, Ischemia-reperfusion Injury, Postconditioning
- Trial name
- NCT00441714
- Testing
- repetitive short ischemia and reperfusion of non dominant fore arm after 10 minute ischemic exercise
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Radboud University Medical Center