Clinical trials: Ischemic Preconditioning
OPCABG
Study on the Myocardial Protective Effect of Upper Limb Ischemic Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
- Trial name
- NCT03340181
- Testing
- RIPC
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Ischemia, Surgery
Ischaemic PReconditioning In Non Cardiac surgEry
Several randomized trials suggested a cardioprotective beneficial effect (eg reduction in cardiac troponin release) of remote ischemic preconditioning in cardiac surgery.
- Trial name
- PRINCE (NCT02427867)
- Testing
- Remote ischemic preconditioning, no ischemic preconditioning
- Where
- 26 sites in China, Colombia and 7 more
- Volunteers
- 1,217 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Kidney Injury
Ischemic Preconditioning to Prevent Acute Kidney Injury
The purpose of this study is to learn about the impact of ischemic preconditioning in reducing contrast induced kidney damage in people with pre-existing kidney problems who are undergoing cardiac catheterization procedures.
- Trial name
- NCT02167152
- Testing
- Ischemic preconditionin
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Kansas Medical Center
Ischemic Preconditioning
Effects of Ischemic Preconditioning on Conditioned Pain Modulation and Heart Rate Variability in Knee Osteoarthritis
Introduction: Musculoskeletal disorders have affected approximately 1.3 billion people worldwide. Evidence shows that chronic diseases and musculoskeletal conditions often occur together, and among them it is estimated that more…
- Trial name
- NCT05059652
- Testing
- Ischemic Preconditioning
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Paulista University
Ischemic Stroke, Remote Ischaemic Preconditioning
Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction
This study aims to conduct a prospective, randomized, double-blind, multicenter, parallel-controlled, group-sequential trialto scientifically evaluate the safety and efficacy of remote ischemic preconditioning (RIC) in preventing…
- Trial name
- RIC-END (NCT07237542)
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 910 people
- Sponsor
- Jinling Hospital, China
Liver Transplantation
The Effects of Glucose/Ischemic Preconditioning on Reperfusion Injury in Deceased-Donor Liver Transplantation
Standard liver retrieval procedures for transplantation from a deceased donor inevitably result in a "reperfusion injury" to the liver tissue.
- Trial name
- NCT00718575
- Testing
- Glucose/Ischemic Preconditioning Pre-treatment
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Osteoarthritis, Knee
Effect of Low Intensity Training Combined With Partial Restriction of Blood Flow in Individuals With Knee Osteoarthritis
Osteoarthritis (OA) is a chronic degenerative infection that presents clinical features such as pain and limited range of motion.
- Trial name
- NCT04819672
- Testing
- Low Intensity Training associated with Partial Blood Flow
- Volunteers
- 66 people
- Sponsor
- Universidade Federal do Ceara
Metabolic Syndrome, Vascular Injury
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury
The objective of this clinical trial is to better understand how lactate, a naturally occurring energy substance, can be used to lessen damage to the vascular system in adults with a high cardiovascular disease risk.
- Conditions
- Metabolic Syndrome, Vascular Injury, Ischemic Preconditioning, Endothelial Function (reactive Hyperemia)
- Trial name
- NCT06825143
- Testing
- Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gary Van Guilder
Abdominal Aortic Aneurysm
Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair
To investigate the influence of limb remote ischemic preconditioning (LRIP) on mortality, hospitalization costs and quality of life in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
- Trial name
- NCT01910961
- Testing
- limb RIPC
- Volunteers
- 360 people
- Sponsor
- Cai Li
Hyperglycemia
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and…
- Trial name
- NCT00995670
- Testing
- 5% dextrose, Vitamin C, Simvastatin
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cardiotoxicity
Remote Ischaemic Preconditioning in Childhood Cancer
Survival rates of children with cancers have improved significantly in the recent few decades. Nonetheless, the side effect of this class of drugs on heart function remains to be an issue of concern.
- Trial name
- NCT03166813
- Testing
- Remote Ischaemic Preconditioning, Control
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Atrial Fibrillation
Effect of Remote Ischemic Preconditioning on Incidence of Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Graft Surgery
Atrial fibrillation is the most common arrhythmic complication after coronary artery bypass grafting (CABG). Post operative atrial fibrillation (POAF) increases morbidity and mortality.
- Trial name
- NCT01500369
- Testing
- sphygmomanometer cuff inflations, standard of care
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- Baystate Medical Center
Heart Ischemia, Cerebral Ischemia
Organ Protection by Remote Ischemic Preconditioning for Surgical Treatment of Pediatric Congenital Heart Disease
Cardiac surgery is associated with risk of perioperative inflammation and ischemia leading to cerebral and myocardial morbidity and mortality.
- Trial name
- RIPHeart (NCT01312623)
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- University Hospital Schleswig-Holstein
Cerebral Aneurysm
Remote Ischemic Preconditioning for Intracranial Aneurysm Treatment
The RIPAT study is a prospective, randomized, double-blind study organized by the neurovascular group of the Clinical Department of Neurosurgery of Innsbruck Medical University, Innsbruck, Austria.
- Trial name
- RIPAT (NCT02162654)
- Testing
- Remote ischemic preconditioning
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University Innsbruck
Transplant Dysfunction
Remote Ischaemic Preconditioning in Transplantation (RIPTRANS)
Remote ischemic preconditioning (RIPC) is a concept where remotely induced ischemia produces protection against ischemia-reperfusion injury in a remote organ.
- Trial name
- NCT03855722
- Testing
- RIPC
- Where
- Finland
- Volunteers
- 496 people
- Sponsor
- Helsinki University Central Hospital
Acute Kidney Insufficiency, Acute Renal Insufficiency
The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery
Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury.
- Conditions
- Acute Kidney Insufficiency, Acute Renal Insufficiency, Acute Kidney Injury, Ischemic Preconditioning
- Trial name
- NCT00821522
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Robert Kramer, MD
Cardiac Surgery
Effect of Remote Ischemic Preconditioning on Cognitive Function After Cardiac Surgery
The purpose of this study is to evaluate the effects of Remote Ischemic Preconditioning on cognitive function in patients undergoing cardiac surgery compared to control intervention.
- Trial name
- NCT00877305
- Testing
- Remote Ischemic Preconditioning, Control
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Patrick Meybohm
Coronary Artery Disease, Diabetes Mellitus
The Effect of Remote Ischemic Preconditioning on Diastolic Function in Coronary Artery Bypass Surgery Between Diabetic and Non-Diabetic Patients
This randomized controlled study aims to evaluate the effects of Remote Ischemic Preconditioning (RIPC) on diastolic function in patients undergoing coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Diastolic Function
- Trial name
- NCT06841757
- Testing
- Remote ischemic preconditioning
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alzahraa Khalil Marie
Ischemia
Collection of Heart Tissue Sample During Open Heart Surgery
This study will collect heart tissue that is routinely removed and discarded during open-heart surgery. The Cardiology Branch of the NHLBI is conducting a variety of laboratory experiments that require a sample of heart tissue.
- Trial name
- NCT00423553
- Where
- United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Abdominal Aortic Aneurysm
Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm
Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%).
- Trial name
- PreconRAAA (NCT00883363)
- Testing
- Precondition
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Nikolaj Eldrup