Clinical trials: Ischemic Stroke, Acute
Acute Ischemic Stroke
Real-World Evaluation of Recombinant Human Prourokinase for Acute Ischemic Stroke Within 4.5 Hours
Acute ischemic stroke is a major cause of disability and death. Intravenous thrombolytic therapy is an important treatment option when given within the appropriate time window.
- Trial name
- PRISM (NCT07787325)
- Testing
- Recombinant Human Prourokinase
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Acute Ischemic Stroke, Mechanical Thrombectomy
Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke
The objective of this clinical trial is to determine whether rapid local ischemic postconditioning (RL-IPostC) is effective in preventing brain edema and safe in acute ischemic stroke (AIS) patients treated with mechanical…
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Ischemic Postconditioning, Brain Edema
- Trial name
- RAPID-SAVE (NCT06307743)
- Testing
- rapid local ischemic postconditioning
- Volunteers
- 135 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Fasting
Randomized Controlled Trial of Time-Restricted Feeding (TRF) in Acute Ischemic Stroke Patients
Many preclinical studies have demonstrated the beneficial effects of intermittent fasting (IF) in a wide range of neurological and cardiovascular diseases.
- Trial name
- NCT04184076
- Testing
- Time-restricted feeding (TRF) with dietary counseling
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Ischemic Stroke
Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke
The purpose of this study is to determine the efficacy of Huatuo Zaizao Pills in improving neural function and life quality in patients with acute ischemic stroke in China.
- Trial name
- HTZZP-INF (NCT01758536)
- Testing
- Huatuo Zaizao Pills
- Where
- 4 sites in China
- Volunteers
- 1,100 people
- Sponsor
- Huashan Hospital
Acute Ischemic Stroke
Serum Neuroglobin and HIF-1α in Acute Ischemic Stroke
Neuroglobin has shown rich neuroprotective effects against cerebral ischemia and hypoxia, and therefore has the potential to impact outcomes after acute ischemic stroke.
- Trial name
- NCT02297984
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai 6th People's Hospital
Acute Ischemic Stroke
Safety and Efficacy of Intravenous Natalizumab in Acute Ischemic Stroke
The primary objective of the study is to assess the clinical effects of natalizumab versus placebo in acute ischemic stroke on clinical measures of functional independence and activities of daily living.
- Trial name
- ACTION2 (NCT02730455)
- Testing
- natalizumab
- Where
- 53 sites in United States, Germany and 2 more
- Volunteers
- 277 people
- Sponsor
- Biogen
Stroke, Ischemic Stroke
Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke
This pilot trial will be the first step toward direct comparison of delivery of endovascular reperfusion therapy to intravenous recombinant tissue plasminogen activator (rt-PA) in a time-to-treatment framework shown as most…
- Trial name
- EARLY (NCT01869478)
- Testing
- Intravenous Thrombolysis, Endovascular Arterial Reperfusion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Stroke, Ischemic, Stroke Syndrome
CUHK Brain Health Longitudinal Study
The goal of this study is to develop a large longitudinal cohort of individuals diagnosed with or at high risk for brain diseases (both neurological and psychiatric in nature), in order to identify risk factors that contribute to…
- Conditions
- Stroke, Ischemic, Stroke Syndrome, Stroke, Stroke, Acute
- Trial name
- BHS (NCT03592563)
- Testing
- Neuro-QoL questionnaire
- Where
- 2 sites in Hong Kong
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Intracranial Atherosclerosis, Acute Ischemic Stroke
Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis
This study will evaluate whether low-density lipoprotein (LDL-C) lowering with alirocumab results in greater change from baseline in intracranial atherosclerotic plaque at week 26 than control in adults with acute ischemic stroke…
- Conditions
- Intracranial Atherosclerosis, Acute Ischemic Stroke, ICAS - Intracranial Atherosclerosis
- Trial name
- TOPICAL-MRI (NCT05001984)
- Testing
- Alirocumab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Ischaemic Stroke
Magnetic Resonance Post-contrast Vascular Hyperintensities at 3 T: a Sensitive Sign of Vascular Occlusion in Acute Ischaemic Stroke
Magnetic resonance imaging (MRI) is the diagnostic cornerstone for precisely identifying acute ischaemic strokes and locating vascular occlusions.
- Trial name
- NCT03971526
- Testing
- MRI images review
- Volunteers
- 130 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Stroke
Serotonin Selective Reuptake Inhibitor (SSRI) Effects on Cerebral Connectivity in Acute Ischemic Stroke
Fluoxetine action on cerebral connectivity changes in acute ischemic stroke patients
- Trial name
- RECONISE (NCT02767999)
- Testing
- Fluoxetine, fMRI
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Toulouse
Acute Ischemic Stroke
Kanagawa Intravenous and Endvascular Treatment Registry
The K-NET registry is a prospective, multicenter, observational registry study for all consecutive patients who received intravenous tPA therapy and/or endovascular treatment for acute ischemic stroke.
- Trial name
- K-NET (NCT05213533)
- Where
- Japan
- Volunteers
- 4,000 people
- Sponsor
- St. Marianna University Toyoko Hospital
Acute Ischaemic Middle Cerebral Artery Stroke
A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke
The aim of this study was to confirm the efficacy of piracetam after 12 weeks of treatment on the aphasic status of subjects suffering from aphasia after acute ischemic middle cerebral artery stroke and having received their…
- Trial name
- NCT01883011
- Testing
- Piracetam
- Where
- 44 sites in Argentina, Austria and 13 more
- Volunteers
- 571 people
- Sponsor
- UCB S.A. - Pharma Sector
Acute Ischemic Stroke
A Study to Evaluate the Intracranial Arterial Recanalization With Multiple Doses of LT3001 Drug Product in AIS Participant
This is a phase II, open-label, single-arm, exploratory study to evaluate the intracranial arterial recanalization of multiple doses of LT3001 drug product in participant with acute ischemic stroke (AIS)
- Trial name
- NCT07890298
- Testing
- LT3001 Drug Product
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Acute Ischemic Stroke
Anesthesia Technique and Outcomes in Mechanical Thrombectomy for Acute Ischemic Stroke
This retrospective cohort study examined clinical outcomes in patients who underwent mechanical thrombectomy for acute ischemic stroke under general anesthesia or sedoanalgesia.
- Trial name
- NCT07422649
- Testing
- General Anesthesia, Sedoanalgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 481 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Ischemic Stroke, Acute Stroke
Aerobic Exercise Training in Acute Ischaemic Stroke
Stroke is a leading cause of adult disability in the UK. There are few treatment options that improve long-term disability outcomes after stroke.
- Conditions
- Ischemic Stroke, Acute Stroke, Cerebrovascular Accident
- Trial name
- ATAS (NCT04742686)
- Testing
- Aerobic exercise training
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Hallam University
Ischemic Stroke
Endothelial Function and Progenitor Cells in Acute Ischemic Stroke
The purpose of this study is to determine whether levels of circulating endothelial progenitor cells (cEPC) are increased in the acute phase of ischemic stroke.
- Trial name
- EPCAS (NCT01289795)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Acute, Stroke
Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
In this prospective cohort study, the investigators aim to investigate the incidence of ICM-detected AF in unselected ischemic stroke patients and its association with anticoagulation initiation and stroke recurrence.
- Conditions
- Stroke, Acute, Stroke, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- NCT05494034
- Testing
- Reveal LINQTM
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Acute Ischaemic Stroke
Combined tDCS+PNS After Acute Stroke
Recent work showed that application of peripheral nerve and cortical stimulation independently can induce 10-15 % improvement in motor performance in patients with chronic stroke.
- Trial name
- NCT01207336
- Testing
- combined transcranial direct current stimulation and electrical peripheral nerve stimulation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute Ischemic Stroke
Evaluation of Xueshuantong in Patients With AcutE IschemiC STroke
The aim is to assess the effects and harms of Xueshuantong lyophilized powder versus placebo in patients with acute ischemic stroke when initiated within 72 hours of symptom onset.
- Trial name
- EXPECT (NCT04415164)
- Testing
- Xueshuantong lyophilized powder, Guidelines-based standard care
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Dongzhimen Hospital, Beijing