Clinical trials: Ischemic and Non-ischemic Cardiomyopathy
Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation
A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter
The purpose of this study is to assess the safety and feasibility of the investigational catheter for mapping the atrial and ventricular regions of the heart.
- Conditions
- Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- FEATHER (NCT07116525)
- Testing
- Paddle-Shaped, High-Density, Multi-Electrode Mapping Catheter
- Where
- 5 sites in Belgium, France and 1 more
- Volunteers
- 90 people
- Sponsor
- Biosense Webster, Inc.
Heart Failure, Cardiomyopathy, Dilated
Impact of Intraventricular Electrical Activation in Resynchronization Therapy
Impact of intraventricular electrical activation in resynchronization therapy. We seek to evaluate the impact of Cardiac Resynchronization Therapy (CRT) on electrical activation of the Left Ventricle (LV).
- Conditions
- Heart Failure, Cardiomyopathy, Dilated, Coronary Disease
- Trial name
- CARTO-CRT (NCT01270646)
- Testing
- Invasive mapping with CARTO3 system and Non-Invasive mapping with CardioInsight Atlas EC Mapping system
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux
Non-ischemic Cardiomyopathy, Heart Failure
LBBP as Initial Therapy in Patients With Non-ischemic Heart Failure and LBBB
The present study will recruit 50 symptomatic non-ischemic cardiomyopathy (NICM) patients with left ventricular ejection fraction (LVEF) below 35% and complete left bundle branch block (CLBBB), who have not received complete…
- Conditions
- Non-ischemic Cardiomyopathy, Heart Failure, Left Bundle-Branch Block
- Trial name
- LIT-HF (NCT05572957)
- Testing
- Guideline-Directed Medical Therapy(GDMT), left bundle branch pacing combined with Guideline-Directed Medical Therapy(LBBP+GDMT)
- Where
- 6 sites in China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sudden Cardiac Death Due to Cardiac Arrhythmia, Cardiomyopathies
Personalized Risk Prediction of Sudden Cardiac Death
Sudden cardiac death (SCD) is the final result of cardiac arrest (CA) , defined as an abrupt and unexpected loss of cardiovascular function resulting in circulatory collapse and death.
- Conditions
- Sudden Cardiac Death Due to Cardiac Arrhythmia, Cardiomyopathies, Ischemic Heart Disease, Cardiovascular Diseases
- Trial name
- RESPECT (NCT06321900)
- Testing
- Personalized risk model
- Where
- Italy
- Volunteers
- 1,050 people
- Sponsor
- Istituto Auxologico Italiano
Non-ischemic Cardiomyopathy
Cardiac Magnetic Resonance for Risk Stratification in Non-dilated Left Ventricular Cardiomyopathy
Non-dilated left ventricular cardiomyopathy (NDLVC), a newly defined cardiomyopathy subtype characterized by non-ischemic myocardial abnormalities without left ventricular dilation, poses challenges in prognosis assessment and…
- Trial name
- NCT07351838
- Testing
- No intervention; Observational study
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure, Left Bundle-Branch Block
Left Bundle Branch Pacing on Outcomes and Ventricular Remodeling in Biventricular CRT Nonresponders
Heart failure (HF) is the most common nosology encountered in clinical practice. Its incidence and prevalence increase exponentially with increasing age and it is associated with the increased mortality, more frequent…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
- Trial name
- RESCUE (NCT05760924)
- Testing
- Cardiac Resynchronization Therapy Devices with Defibrillator Function (CRT-D) or CRT-D Leads Replacement, CRT-D or CRT-D Leads Replacement with New Lead Implantation to Left Bundle Branch and Inactivation of Conventional Right and Left Ventricular Pacing, CRT-D or CRT-D Leads Replacement with New Lead Implantation to Left Bundle Branch and Inactivation of Conventional Right Ventricular Pacing
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Extracorporeal Membrane Oxygenation, Septic Shock
ExtraCorporeal Membrane Oxygenation in the Therapy for REfractory Septic Shock With Cardiac Function Under Estimated
The ECMO-RESCUE study is a prospective, multicenter, non-randomized, cohort study. In this study, we aimed to assessed whether VA-ECMO treatment can improve the 30-day survival rate of patients with sepsis-induced refractory…
- Conditions
- Extracorporeal Membrane Oxygenation, Septic Shock, Septic Cardiomyopathy, Cardiogenic Shock
- Trial name
- ECMO-RESCUE (NCT05184296)
- Testing
- Extracorporeal Membrane Oxygenation (ECMO)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Mitral Valve Insufficiency, Dilated Cardiomyopathy
Prospective Study Looking at Quality of Life Measures in Non-ischaemic Cardiomyopathy After Mitral Valve Repair
Chronic severe mitral regurgitation can lead to symptoms and left ventricular dysfunction. The purpose of this study is to prospectively follow patients with non-ischaemic cardiomyopathy who are eligible for mitral valve repair…
- Conditions
- Mitral Valve Insufficiency, Dilated Cardiomyopathy, Congestive Heart Failure
- Trial name
- NCT00483236
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ischemic Cardiomyopathy
A Phase I Study of Allogeneic Myocardium-Derived Mesenchymal Stem Cells (HB1011) in Patients With Ischemic Cardiomyopathy
Ischemic cardiomyopathy occurs when the heart muscle is permanently weakened due to blocked coronary arteries that limit blood flow.
- Trial name
- HEART-1 (NCT07861035)
- Testing
- HB1011 (Allogeneic Myocardium-derived Mesenchymal Stem Cells)
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- HieraBio Inc.
Scar-related Monomorphic Sustained VT
Pivotal Study to Evaluate Catheter Ablation in Patients With Scar-Related Monomorphic Sustained VT in the Ventricular Ectopy and Reduction in Tachycardia Ablation Studies Program VERITAS SCAR VT
The VERITAS VT Study is a prospective, multicenter, international, single-arm clinical investigation designed to evaluate the safety and effectiveness of the FieldForce™ Pulsed Field Ablation System for the treatment of sustained…
- Trial name
- NCT07794215
- Testing
- System is an investigational catheter-based device designed to deliver pulsed field ablation energy to cardiac tissue for the treatment of sustained monomorphic VT
- Volunteers
- 180 people
- Sponsor
- Field Medical
Cardiomyopathy (Ischemic or Non-Ischemic)
DNA/RNA Analysis of Blood and Skeletal Muscle in Patients Undergoing Cardiac Resynchronization Therapy (CRT)
Genes expressing inflammatory cytokines (TNF- alpha, IL1 etc) and genes involved in apoptosis (Caspase 3, Bax, Bcl-2, Fas) are dysregulated in the skeletal muscles of the patients who have muscle wasting and decreased exercise…
- Trial name
- Medusa PH (NCT00600392)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Ventricular Tachycardia (VT), Ischemic Cardiomyopathy
MRI-guided Ventricular Tachycardia Ablation in Patients With Structural Heart Disease
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder that frequently occurs in patients with structural heart disease, such as ischemic or non-ischemic cardiomyopathy.
- Conditions
- Ventricular Tachycardia (VT), Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- MAGNET-VT (NCT07896980)
- Testing
- LGE-MRI-integrated EAM-guided catheter ablation, Conventional EAM-guided catheter ablation
- Where
- China
- Volunteers
- 526 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiomyopathy, Coronary Artery Disease
The Prognostic Significance of Fibrosis Detection in Cardiomyopathy
The presence of scar within heart muscle can act as a substrate for abnormal rhythm problems and lead to the developement of heart failure Clinical significance Correlation with biomarkers and genetic markers
- Trial name
- NCT00930735
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Dilated Cardiomyopathy
Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy
The main aim of the study is to determine whether intracoronary infusion of autologous bone marrow mononuclear cells can improve the ventricular function of patients with idiopathic dilated cardiomyopathy.Secondary end-points…
- Trial name
- NCT00629096
- Testing
- Intracoronary infusion of autologous bone marrow cells
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
A Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure
The purpose of this trial is to assess whether MYDICAR can reduce the frequency and/or delay heart failure related hospitalizations in persons with advanced heart failure when added to their maximal and optimized therapy.
- Conditions
- Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy, Heart Failure, Cardiomyopathies
- Trial name
- CUPID-2b (NCT01643330)
- Testing
- AAV1/SERCA2a (MYDICAR)
- Where
- 54 sites in United States, Belgium and 8 more
- Volunteers
- 250 people
- Sponsor
- Celladon Corporation
Heart Failure, Microvascular Angina
Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology
This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with…
- Conditions
- Heart Failure, Microvascular Angina, Non-ischemic Cardiomyopathy
- Trial name
- HFrEF-CMD (NCT06243653)
- Testing
- CMD test
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Ischaemic Cardiomyopathy, Non-ischaemic Cardiomyopathy
Profitability Trial in Primary Preventive Implantable Cardioverter-defibrillator Recipients
The purpose of this study is further risk stratification of patients receiving implantable cardioverter-defibrillator in primary prevention of sudden cardiac death.
- Trial name
- HAPPIER (NCT01823211)
- Where
- 3 sites in Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Ostrava
Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM)
Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.
Non-ischemic cardiomyopathies (NICM) represent a heterogeneous group of pathologies characterized by absence of obstructive disease of the epicardial coronary vessels and distinct structural and functional changes of the…
- Conditions
- Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Restrictive Cardiomyopathy
- Trial name
- AINICM (NCT06607471)
- Testing
- Support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation, Support treatment, cardiac medical treatment, aetiology-specific treatment
- Where
- Italy
- Volunteers
- 15,000 people
- Sponsor
- Scientific Institute San Raffaele
Congestive Heart Failure
Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure
This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single dose of AB-1002, administered via antegrade intracoronary artery infusion, in…
- Trial name
- GenePHIT (NCT05598333)
- Testing
- AB-1002
- Where
- 96 sites in United States, Austria and 10 more
- Volunteers
- 150 people
- Sponsor
- AskBio Inc
Cardiovascular Diseases, Heart Failure
Longitudinal Validation of CIRC Technologies
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization.
- Conditions
- Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy
- Trial name
- NCT07081711
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic