Clinical trials: Islets of Langerhans Transplantation
Diabetes type1
cePolyTregs in Islet Transplantation
The transplant of the insulin-producing cell into the liver (Islet transplant) has been proven an effective and valuable treatment for type 1 diabetics patients with poor blood sugar.
- Trial name
- cePolyTregs (NCT05349591)
- Testing
- cePolytreg
- Where
- Canada
- Sponsor
- University of Alberta
Islet Transplantation, Type 1 Diabetes
Comparison of Sirolimus Alone With Sirolimus Plus Tacrolimus in Type 1 Diabetic Recipients of Cultured Islet Cell Grafts
Proof of concept study in islet transplantation, two treatment arms (ATG SIR-TAC versus ATG SIR) each consisting of ten type 1 diabetic patients
- Trial name
- NCT00409461
- Testing
- ATG-Sirolimus-Tacrolimus
- Where
- 2 sites in Belgium
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetes Mellitus, Type I
Study of Islet Transplantation in Type 1 Diabetic Kidney Transplant Recipients
The purpose of the study is to learn if islet transplantation is an effective treatment for Type 1 diabetes in people who have had a kidney transplant.
- Trial name
- NCT00888628
- Testing
- Purified Pancreatic Islets, Etanercept
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus
Modification of the "Edmonton Protocol" to Allow for Successful Islet Transplantation From a Single Pancreas and Extension of the "Edmonton Protocol" to Kidney Transplant Recipients
The experience of the Edmonton Group with islet transplantation and use of the "Edmonton Protocol" provides much promise for T1DM patients.
- Trial name
- NCT00021580
- Testing
- human cadaveric islet cell transplantation
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Type 1 Diabetes
11C-5-HTP PET in Clinical Islet Transplantation
In people with type I diabetes, the insulin producing cells in the pancreas have been destroyed. Presently one can only evaluate the function of the graft through laboratory tests, blood sugars and the insulin requirements.
- Trial name
- NCT02689479
- Testing
- Positron-Emission Tomography, 11C-5-HTP, Magnetic Resonance Imaging
- Where
- 2 sites in Sweden
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes Mellitus
Islet Cell Transplant for Type 1 Diabetes
City of Hope National Medical Center, located in Duarte, CA, is hosting a clinical study on islet cell transplantation, an experimental procedure being evaluated as a treatment for patients with type 1 diabetes.
- Trial name
- TCD (NCT01909245)
- Testing
- Allogenic Human Islet Cells, Immunosuppressive Agents, Gastrin 17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Diabetes Mellitus, Type 1
Islet Transplantation in Type 1 Diabetic Patients Using the Edmonton Protocol of Steroid Free Immunosuppression
The primary purpose of this study is to demonstrate the safety of allogeneic islet transplantation in type 1 diabetic patients performed at the University of Illinois at Chicago (UIC).
- Trial name
- NCT00566813
- Testing
- Islet Cell Transplant, Islet Cell Transplant plus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois Chicago
Type 1 Diabetes, Postpancreatectomy Hyperglycemia
Bone Marrow as an Alternative Site for Islet Transplantation
The goal of this study is to evaluate safety and feasibility of bone marrow (BM) as site for islet transplantation (Tx) in humans.
- Trial name
- NCT01345227
- Testing
- Intra bone marrow islet infusion
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Ospedale San Raffaele
Diabetes Mellitus
Patterns and Natural History of Insulin Secretion in Islet Cell Transplant Recipients and Controls
This grant is to study patients that have received a kidney transplant AND an Islet Cell transplant and to discover how the transplant is functioning.
- Trial name
- NCT00018122
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Type 1 Diabetes Mellitus
Islet Cell Transplantation Alone and CD34+ Donor Bone Marrow Cell Infusion in Type 1 Diabetes Mellitus
SPECIFIC AIMS: To reverse hyperglycemia and insulin dependency in patients with Type 1 diabetes mellitus by islet cell transplantation.
- Trial name
- NCT00315614
- Testing
- Islet Transplantation and Bone Marrow
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Miami
Pancreatic Islet Quality Control
Quality Control of Pancreatic Islet Intended to Islet Graft Cells Intended to Stabilot Islet Graft Protocol
Islet quality control after pancreatic islets isolation process is insufficient. The Islet Chip study proposes to develop a bio-sensor that will allow a multi-parametric analysis of islet graft based on measurement of islet…
- Trial name
- ISLET CHIP (NCT03067324)
- Where
- 8 sites in France, Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes Mellitus
Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study.
This research project is supported by a multicentric network of collaborators whose goal is to assess the efficacy of transplanting allogenic pancreas islets to restore insulin secretion in patients with brittle type 1…
- Trial name
- NCT00321256
- Testing
- human pancreatic islet transplantation
- Where
- 6 sites in France, Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes
Clinical Islet Transplantation Using the Edmonton Protocol
The purpose of this study is to perform a series of islet transplants using the Edmonton protocol. Patients with Type I Diabetes and glycemic lability, severe hypoglycemia or hypoglycemic unawareness will undergo transplantation…
- Trial name
- NCT00309231
- Testing
- Islet Allotransplantation
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Type 1 Diabetes Mellitus
Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging
The primary objective of this pilot study is to assess the feasibility and safety of ex vivo islet labelling prior to intraportal transplantation in patients with type 1 diabetes with the purpose of islet graft imaging.
- Trial name
- NCT00453817
- Testing
- ferucarbotran (iron-based MRI contrast agent), Islet transplantation, Magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University Hospital, Geneva
Islets of Langerhans Transplantation, Pancreatitis, Chronic
Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation
A total pancreatectomy with islet autotransplantation (TPIAT) can be performed for a number of benign indications, such as chronic pancreatitis.
- Conditions
- Islets of Langerhans Transplantation, Pancreatitis, Chronic, Diabetes Mellitus
- Trial name
- TOPPER (NCT05287737)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Type 1 Diabetes
Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
The main goal is to perform a cost-utility analysis to compare islet cell transplantation versus best medical treatment (defined as Sensor augmented pump therapy) for patients with brittle type1 diabetes.
- Trial name
- STABILOT (NCT02854696)
- Testing
- Islet graft, best medical care
- Where
- 11 sites in France, Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes Mellitus, End-stage Renal Disease
Simultaneous Islet-Kidney Transplantation in Patients of Type 1 Diabetes With End-stage Renal Disease
The aim of this study was to evaluate the efficiency and safety of simultaneous islet-kidney transplantation in patients of type 1 diabetes with end-stage renal disease using a glucocorticoid-free immunosuppressive regimen with…
- Trial name
- NCT00692562
- Testing
- simultaneous islet-kidney transplantation
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Fuzhou General Hospital
Type 1 Diabetes
Device-Less Technique in Islet Transplantation
Islet transplantation is an effective modality for treating type 1 diabetes. Despite marked progress in clinical islet transplantation with the achievement and maintenance of insulin independence in over half of recipients up to…
- Trial name
- NCT05073302
- Testing
- Implantation of Nylon catheter (Device-less sentinel unit)
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi
Brittle Type 1 Diabetes Mellitus
Allogeneic Regenerative Islet Transplantation for the Treatment of Brittle Type 1 Diabetes Mellitus
This is a single-center, single-arm Phase Investigational Intervention Trial (IIT) clinical trial aimed at evaluating the safety and efficacy of allogeneic regenerative islet transplantation for the treatment of brittle type 1…
- Trial name
- NCT06196996
- Testing
- The method of islet transplantation is through percutaneous transhepatic portal vein puncture.
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Changzheng Hospital