Clinical trials: Islets of Langerhans Transplantation
Type 1 Diabetes
Energy Balance Following Islet Transplantation
Islet transplantation may be appropriate in up to 10% of adults with Type 1 diabetes who suffer repeated episodes of hypoglycaemia with severely impaired awareness of hypoglycaemia (IAH) (1).
- Trial name
- EBFIT (NCT03063229)
- Testing
- Accelerometer, Anthropomentry, Blood tests
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Type 1 Diabetes Mellitus
Pancreatic Islet Transplantation in the Anterior Chamber of the Human Eye - a Pilot Study
The overall objective is to establish that transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye is safe and does not cause ophthalmic or systemic…
- Trial name
- NCT02916680
- Testing
- Pancreatic islet transplantation in the anterior chamber
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- University Hospital, Basel, Switzerland
Type1diabetes, Hypoglycemia
Adrenergic System in Islet Transplantation
To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation.
- Conditions
- Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness, Islet Cell Transplantation
- Trial name
- NCT03079921
- Testing
- Phentolamine, Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Type 1 Diabetes Mellitus
Heparinized Islets in Clinical Islet Transplantation
In this study the islets will be surface modified to carry immobilised heparin (Corline Heparin Conjugate) prior to transplantation.
- Trial name
- NCT00678990
- Testing
- Transplantation of islets with heparin coating
- Where
- 2 sites in Sweden
- Volunteers
- 10 people
- Sponsor
- Corline Biomedical AB
Diabetes Mellitus
Islet After Kidney Transplantation (IAK) in Patients With Type 1 Diabetes
The purpose of this study is to determine the safety of islet transplantation in patients with type 1 diabetes who have had a successful kidney transplant and have been maintained for at least three months on anti-rejection…
- Trial name
- NCT00708604
- Testing
- Islet Transplantation, Islet cell transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- City of Hope Medical Center
Diabetes Mellitus
Complement Inhibitor Eculizumab in Clinical Islet Transplantation
This is a dual centre, single arm, exploratory study of the possibility to use eculizumab (Soliris) to prevent/reduce destruction of islets of Langerhans after portal infusion of the islets in patients with diabetics accepted for…
- Trial name
- ICC (NCT02727608)
- Testing
- Eculizumab
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Uppsala University
Type 1 Diabetes Mellitus, Hypoglycemia
Allogeneic Islet Cells Transplanted Onto the Omentum
Current islet transplantation into the portal vein of the liver has shown the unique ability of islets to stabilize blood glucose levels and prevent severe hypoglycemia in a selected group of subjects with Type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT02213003
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rodolfo Alejandro
Diabetes
Nitrite Infusion in Islet Cell Transplantation
This study seeks to investigate the effects of administering nitrite to pancreatic islet cells that have been removed from a patient for autotransplantation.
- Trial name
- NCT03544242
- Testing
- Control, Pre-Isolation Infusion, Post-Isolation Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
Tegoprubart (AT-1501) is a monoclonal antibody. Antibodies are Y-shaped proteins that are produced naturally by the subject's immune system to attack and fight foreign substances that cause illness.
- Trial name
- Tegoprubart (NCT06305286)
- Testing
- Islet transplantation with Tegoprubart (AT-1501) immunosupression-based therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Chicago
Cystic Fibrosis, Diabetes Related Cystic Fibrosis
Metabolic Efficiency of Combined Pancreatic Islet and Lung Transplant for the Treatment of End-Stage Cystic Fibrosis
Patients with end-stage cystic fibrosis (CF) and severe CF-related diabetes (CFRD) may benefit from combined lung-pancreatic islet transplantation.
- Conditions
- Cystic Fibrosis, Diabetes Related Cystic Fibrosis, Insulin-dependent Diabetes
- Trial name
- PIM (NCT01548729)
- Testing
- Combined pancreatic islet and lung transplantation
- Where
- 28 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Diabetes Mellitus, Type 1, Immunologic Deficiency Syndromes
Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM
This study evaluates the efficacy of sequential transplantation of umbilical cord blood stem cells and islet cells in children with monogenic immunodeficiency type 1 diabetes mellitus.
- Trial name
- NCT03835312
- Testing
- Sequential transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Fudan University
Diabetes Mellitus, Type 1
Islet Cell Transplants for Diabetes
The purpose of this study is to test the safety and efficacy of islet cell transplants for the treatment of type 1 diabetes mellitus.
- Trial name
- NCT00303134
- Testing
- Islet Cell Transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
Type1diabetes
First-in-human Safety Study of Hypoimmune Pancreatic Islet Transplantation in Adult Subjects With Type 1 Diabetes
The current study tests the hypothesis whether genetically modified Langerhans islet cells containing insulin-producing cells from a deceased organ donor can 1. be transplanted safely and 2.
- Trial name
- NCT06239636
- Testing
- UP421
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Per-Ola Carlsson
Type 1 Diabetes Mellitus
Mechanisms of Glucose Counterregulation in Pancreatic Islet Transplantation
Pancreatic islet transplantation improves glucose counterregulation and stabilizes glycemic control in patients with type 1 diabetes mellitus prone to severe hypoglycemia even if insulin independence is not achieved.
- Trial name
- NCT01668485
- Testing
- Hypoglycemic and euglycemic glucose clamp
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Transplant
Immune Response to Influenza Vaccine in Islet Cell Transplant Recipients
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia. Although the annual influenza vaccine is recommended for organ transplant patients, studies have shown…
- Trial name
- NCT01149382
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Alberta
Diabetes
Autologous Regenerative Islet Transplantation for Insulin-dependent Diabetes
This is a single-center, phase IIT clinical trial to evaluate autologous regenerative islet transplantation for insulin-dependent diabetes mellitus.
- Trial name
- NCT05294822
- Testing
- Autologous regenerative islet transplantation for insulin-dependent diabetes mellitus
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Changzheng Hospital
Type 1 Diabetes Mellitus
Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients
The study evaluates the safety and efficacy of Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients.
- Trial name
- NCT00646724
- Testing
- cotransplantation of islet and mesenchymal stem cell
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fuzhou General Hospital