Clinical trials: Isolation
Persistent Atrial Fibrillation
Circumferential Pulmonary Venous Isolation Combined With Bachmann Bundle Modification Versus Circumferential Pulmonary Venous Isolation for Persistent Atrial Fibrillation
This study is a prospective, randomized controlled, single-blind, multicenter study design. To evaluate the safety and efficacy of traditional pulmonary vein isolation (PVI) alone and PVI combined with Bachmann bundle ablation on…
- Trial name
- NCT07445360
- Testing
- Traditional pulmonary vein isolation (PVI) ablation, Bachmann bundle modification
- Volunteers
- 320 people
- Sponsor
- Shenyang Northern Hospital
Mental Disorders
Impact of Joint Crisis Plan
For some patients in department psychiatric, isolation measures are put in place. But the measures is not pleasant for the patient or for the care team.
- Trial name
- PLANCO-ISO (NCT03984682)
- Testing
- Joint Crisis Plan
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Depression, Depressive Disorder
The Preliminary Effects of Empower@Home
This randomized pilot trial uses a waitlist control parallel design of a novel internet-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- NCT05593276
- Testing
- Empower@Home
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Michigan
Chronic Pancreatitis
Carbon Monoxide-Saturated Medium for Islet Isolation
The goal of this study is to determine whether harvesting islets using carbon monoxide (CO)-saturated mediums can protect islet cell from death after autologous islet transplantation in patients with chronic pancreatitis.
- Trial name
- NCT02567240
- Testing
- Carbon monoxide-bubbled mediums
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
AF - Atrial Fibrillation, HTN-Hypertension
Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Atrial Fibrillation (AF) and Hypertension (HTN)
The close relationship between the increase of sympathetic tension, AF, and HTN cannot be ignored. In addition, the significant failure rate of PVI (20-50%) in the treatment of AF makes it very necessary to explore the effect of…
- Trial name
- NCT05841615
- Testing
- Renal Denervation operation, Pulmonary vein isolation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Atrial Fibrillation, Persistent, Arrhythmias, Cardiac
Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation
This study is to assess the effectiveness and safety of using cryoballoon ablation comparing with anti-arrhythmic drug therapy as initial treatment for naive patients with persistent atrial fibrillation.
- Trial name
- Cryo-InitialAF (NCT04942834)
- Testing
- Antiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone, cryoballoon ablation
- Where
- 17 sites in China
- Volunteers
- 320 people
- Sponsor
- Ruijin Hospital
Pneumonia, Intensive Care Unit
Effects of Isolated Rooms on the Prevalence of Hospital Acquired Pneumonia in a Respiratory ICU
This study will carry out in the ICU. Objectives of the study are to determine the frequency of HAP and the effect of isolated rooms on the frequency of pneumonia in the ICU.
- Trial name
- NCT01250691
- Testing
- ward-type ICU
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 532 people
- Sponsor
- Eskisehir Osmangazi University
Paroxysmal Atrial Fibrillation, Atrial Fibrillation
Adjunctive Ganglionated Plexus Ablation in Redo-Pulmonary Vein Isolation
The investigator propose to test the efficacy of adjunctive ET-GP ablation in patients undergoing redo PVI for paroxysmal AF.
- Trial name
- ADD-GP (NCT03535818)
- Testing
- Radiofrequency ablation
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Optic Neuritis
Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial
This clinical trial aims at preventing visual dysfunction and optic nerve degeneration associated with autoimmune optic neuritis by systemic i.v. administration of 33.000 IU erythropoietin over 3 days.
- Trial name
- TONE (NCT01962571)
- Testing
- Erythropoietin alfa
- Where
- 11 sites in Germany
- Volunteers
- 108 people
- Sponsor
- University Eye Hospital, Freiburg
Ankle Fractures
Operative Versus Non Operative Management Outcomes of Isolated Lateral Malleolar Weber B Ankle Fractures
The primary objective of this study is to determine the failure rate and difference in clinical outcomes between operative and non operative treatment of patients with Weber B lateral malleolus ankle fractures with medial clear…
- Trial name
- NCT03625154
- Testing
- ankle open reduction internal fixation, non operative management
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Comorbidities and Coexisting Conditions, Social Isolation
The PREPARE for COVID Trial
This is a randomized trial of home-based exercises versus control for older adults during the COVID-19 pandemic. The hypothesis is that participation in a home-based program will reduce the risk of adverse effects of physical…
- Trial name
- NCT04392115
- Testing
- The PREPARE program
- Volunteers
- 372 people
- Sponsor
- Ottawa Hospital Research Institute
Social Isolation
ENRED@TE. Social Support in Southern Spain. Interventional Study
The main objective to be achieved is to find out if the perceived social support, the perceived loneliness, the perceived social isolation and the family support of those over 65 years of age improve after participating in the…
- Trial name
- NCT04567940
- Testing
- ENRED@TE: Behavioural multicomponent intervention
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Elderly Volunteers
Characterization of Fecal Microbiota in a Population Aged 50 to 75 Years Targeted by Seasonal Vaccination
The goal of this interventional study is to constitute a biological samples collection collected from healthy elderly volunteers and used for scientific purposes.
- Trial name
- FIFTY+ (NCT05972590)
- Testing
- Biological samples collection (blood + feces)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bioaster
Hypotonia Cystinuria Syndrome, Isolated PREPL Deficiency
Sulfamethoxazole for the Treatment of Primary PREPL Deficiency
The investigators will evaluate whether sulfamethoxazole, a sulfamide antibiotic, improves the symptoms of primary PREPL deficiency (hypotonia-cystinuria syndrome and isolated PREPL deficiency).
- Trial name
- SPPD (NCT02640443)
- Testing
- Sulfamethoxazole
- Volunteers
- 15 people
- Sponsor
- Universitair Ziekenhuis Brussel
Stress, Anxiety
Minerals and Botanicals for Acute Stress
The objective of this acute intervention study is to examine the potential of minerals combined with botanicals to demonstrate unique and synergistic effects on oscillatory brain activity, cognitive performance, and stress…
- Trial name
- NCT03262376
- Testing
- Minerals + Vitamins, Botanical A, Botanical B
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Anterior Cruciate Ligament Rupture, Ligament Knee Injury
Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction
Abstract Introduction: Autologous hamstring tendons are the most commonly used grafts in ACL reconstruction worldwide. There are several ways to prepare the graft using these tendons.
- Trial name
- NCT06505525
- Testing
- Extra-articular reconstruction with the Anterolateral Ligament
- Where
- 2 sites in Brazil
- Volunteers
- 146 people
- Sponsor
- Federal University of São Paulo
Recurrent Colon Cancer, Liver Metastases
Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different ways may kill more tumor cells.
- Conditions
- Recurrent Colon Cancer, Liver Metastases, Stage IV Rectal Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00019760
- Testing
- floxuridine, leucovorin calcium, melphalan
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Isolated Chemotherapy-induced Thrombocytopenia
Study of Romiplostim for Chemotherapy Induced Thrombocytopenia
This study is to determine if using weekly romiplostim injections will improve the patient's platelet count more effectively than simply waiting for the platelets to improve on its own, and if romiplostim will also allow the…
- Trial name
- NCT02052882
- Testing
- romiplostim
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Achilles Tendon Repairs/reconstructions, Achilles Tendon Rupture
Flexor Hallucis Longus Tendon Transfer VS Gastrocnemius Augmented Flexor Hallucis Longus Tendon Transfer in Management of Achilles Tendon Defect
This study aims to compare the functional outcome of Isolated Flexor hallucis longus tendon transfer and Gastrocnemius Augmented Flexor hallucis longus tendon transfer in repair of Achilles tendon defects.
- Trial name
- NCT06847971
- Testing
- Flexor hallucis longus tendon transfer, Gastrocnemius augmented Flexor hallucis longus tendon transfer
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Assiut University
Intracranial Pressure, Intracranial Pressure Changes
Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein
Elevated intracranial pressure is a common complication of brain injury which means that the pressure within the skull rises above normal levels.
- Trial name
- NCT07222826
- Testing
- CPMX3
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Compremium AG
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