Clinical trials: Isolation
Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy
Non-invasive Prenatal Diagnostic Validation Study
The primary purpose of this study is to collect maternal blood samples from pregnant women to develop a non-invasive prenatal diagnostic test based on fetal DNA isolated from maternal blood.
- Conditions
- Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy, Chromosome 21 Aneuploidy, Sex Chromosome Aberrations
- Trial name
- NIPD (NCT01574781)
- Testing
- Blood draw, Cheek swab/Saliva Sampling
- Where
- United States
- Volunteers
- 1,781 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Multiple Sclerosis, Relapsing-Remitting
RItuximab Versus FUmarate in Newly Diagnosed Multiple Sclerosis.
A randomized phase 3 study comparing Rituximab with Dimethyl Fumarate in early Relapsing-Remitting Multiple Sclerosis and Clinically Isolated Syndrome.
- Trial name
- RIFUND-MS (NCT02746744)
- Testing
- Rituximab, Dimethyl fumarate, Sodium Chloride solution
- Where
- 17 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Anders Svenningsson
Loneliness, Social Isolation
Evaluation of the Nextdoor KIND Challenge
There is ample evidence showing that loneliness is a public health problem that influences social, mental and physical health. The current project is about evaluating the effectiveness of the Kindness Is NextDoor (KIND)…
- Trial name
- NCT04398472
- Testing
- KIND Challenge
- Where
- Australia
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Swinburne University of Technology
Colorectal Cancer, Metastatic Cancer
Isolated Hepatic Perfusion With Melphalan in Treating Patients With Unresectable Colorectal Cancer That Has Metastasized to the Liver
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs in different ways may kill more tumor cells.
- Trial name
- NCT00089401
- Testing
- isolated perfusion, melphalan, conventional surgery
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Head Injury Trauma
Treatment and Outcome of Patients With Mild Head Injury
The study aims to assess the incidence of complications, such as intracranial haemorrhages and neurological deficits, in patients with head trauma treated in the emergency departments of the Emilia-Romagna Region and to compare…
- Trial name
- BTER23 (NCT07339319)
- Where
- 4 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Atrial Fibrillation, Heart Failure
Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation With Heart Failure
The combination of atrial fibrillation (AF) and heart failure (HF) is common and implies a poor prognosis. Pulmonary vein isolation is an established method for the treatment of symptomatic AF in patients with normal heart…
- Conditions
- Atrial Fibrillation, Heart Failure, Cryoballon Ablation
- Trial name
- POLAR-HF (NCT04461691)
- Testing
- Cryoballoon Pulmonary Vein Isolation
- Where
- Germany
- Volunteers
- 1,420 people
- Sponsor
- St. Josefs-Hospital Wiesbaden GmbH
Atrial Fibrillation
Use of Volta Medical AI-software During Atrial Fibrillation Ablation to Identify Patients Who May Need More Than Pulmonary Vein Isolation.
DISPLAY-AF is a prospective, multicenter, single-arm post-market clinical follow-up investigation designed to evaluate whether spatiotemporal dispersion areas identified by the Volta AF-Xplorer II artificial intelligence (AI)…
- Trial name
- DISPLAY-AF (NCT07807423)
- Testing
- Complete biatrial mapping
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Volta Medical
Social Isolation, Loneliness (Descriptors Included in the MeSH)
Effectiveness of a Intervention to Reduce the Social Isolation and Loneliness of Elderly Residents at Home
Objectives: To evaluate the effectiveness, in terms of reducing social isolation and improving the Health Related Quality of Life (HRQOL), of a non-pharmacological multicomponent intervention in elderly telecare users.
- Trial name
- ASyS (NCT03345862)
- Testing
- non-pharmacological multicomponent
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Andaluz Health Service
Atrial Fibrillation (AF)
Dual-Energy Lattice-Tip Assisted Marshall-Plan Strategy in Redo Persistent Atrial Fibrillation Ablation
This clinical trial will assess the efficacy and safety of a Marshall plan-based ablation strategy without ethanol infusion into the vein of Marshall in patients with persistent atrial fibrillation undergoing repeat ablation with…
- Trial name
- DELTA-MAP AF (NCT07899918)
- Testing
- Marshall Plan-Based Ablation Strategy, PV re-isolation only, Additional Left Atrial Ablation
- Where
- Sweden
- Volunteers
- 234 people
- Sponsor
- Karolinska University Hospital
Radiologically Isolated Syndrome, Multiple Sclerosis
Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.
Radiologically isolated syndrome (RIS) often precedes Multiple Sclerosis (MS) but some patients have no symptoms. This study aims to use biological samples and magnetic resonance imaging (MRI) data from four large cohorts of…
- Trial name
- ProBioRIS (NCT06395662)
- Testing
- Observational
- Where
- 3 sites in United States, France
- Volunteers
- 320 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Oligohydramnios
The Effect of Oral Hypotonic Hydration in Isolated Oligohydramnios
OBJECTIVE: The primary objective of our study is to compare the effects of routine hydration with additional 2 liters of normal water versus orally 2 liters of distilled water on the amount of amniotic fluid.
- Trial name
- NCT05332015
- Testing
- Hypotonic (distilled) water, Normal water
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Antalya Training and Research Hospital
Atrial Fibrillation
Cryoenergy Or Radiofrequency for Pulmonary Vein Isolation
This is a prospective single-center randomized trial comparing the efficacy and safety of PV cryoablation with the Arctic Front® catheter versus the standard PV isolation using radiofrequency irrigated tip catheters.
- Trial name
- COR (NCT00969735)
- Testing
- Pulmonary vein cryoablation, Pulmonary vein radiofrequency ablation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital San Carlos, Madrid
Hypertension, Systolic, Metabolic Syndrome
Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure
The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over one week in patients with metabolic…
- Conditions
- Hypertension, Systolic, Metabolic Syndrome, Typ 2 Diabetes
- Trial name
- APCIQ-BP (NCT05903950)
- Testing
- Air cleaners with HEPA filter, Air cleaners without HEPA filter
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Weill Cornell Medical College in Qatar
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Hypertension (HTN), Heart Failure With Preserved Ejection Fraction (HFpEF
Clinical Feasibility of Cardiac Neuromodulation Therapy for Heart Failure With Preserved Ejection Fraction
This is an open-label pilot study to evaluate the feasibility of Cardiac Neuromodulation Therapy (CNT) in patients with high blood pressure and heart failure who require dual-chamber pacemaker implantation or replacement.
- Conditions
- Hypertension (HTN), Heart Failure With Preserved Ejection Fraction (HFpEF, Hypertension, Systolic
- Trial name
- NCT07598760
- Testing
- Moderato Plus device with Cardiac Neuromodulation Therapy
- Where
- 2 sites in Georgia
- Volunteers
- 20 people
- Sponsor
- BackBeat Medical Inc
Atrial Fibrillation
MARSHALL PLAN Vs. Pulmonary Veins Isolation Monocentric Trial
In ablation strategy for persistent Atrial Fibrillation (PsAF), ablation limited to Pulmonary Vein (PV) isolation is the most straightforward approach but the result give only 50% of arrhythmia free follow-up.
- Trial name
- PLAN-MARSHALL (NCT04206982)
- Testing
- Destruction of Marshall bundles, Pulmonary veins isolation, Linear ablation in the left and right atria
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Bordeaux
Mental Health Disorder, Social Isolation
Peer Support Intervention to Mitigate Social Isolation and Stigma of Adolescent Motherhood in Zimbabwe
A community-based peer support intervention for adolescent mothers aged 14-18 years in Harare, Zimbabwe was developed and tested in partnership with adolescent mothers, community health workers, and key community stakeholders.
- Conditions
- Mental Health Disorder, Social Isolation, Stigma, Social
- Trial name
- NCT05213182
- Testing
- Young Women of Today
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- West Chester University of Pennsylvania
Hypopituitarism, Central Diabetes Insipidus
Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Hypopituitarism, Central Diabetes Insipidus, Panhypopituitarism, Psychological Disorder
- Trial name
- NCT04897802
- Testing
- Experimental: GLP1-RA (exenatide) administration
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Atrial Fibrillation Paroxysmal, Catheter Ablation
Randomized Trial: High Power Short Duration Versus Ablation Index
The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) varies between 80 and 90 %.
- Trial name
- NCT05251545
- Testing
- Pulmonary vein isolation
- Where
- Germany
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Medical Center
Health Behavior, Health Related Physical Fitness
Impact of a Physical Activity Program on the Mental Health of Medical Students.
University students frequently adopt a sedentary lifestyle with low levels of physical activity, leading to a deterioration in their health. A significant number of them also suffer from social isolation.
- Conditions
- Health Behavior, Health Related Physical Fitness, Mental Health, Sedentary Behaviors
- Trial name
- SANTE (NCT06822075)
- Testing
- SANTE program
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Research on Healthcare Performance Lab U1290
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