Clinical trials: Isolation
Multiple Sclerosis
E-Support Groups in Multiple Sclerosis
Primary objectives: To determine the feasibility of program (80% retained with 75% overall attendance, and completed immediate follow-up questionnaires from 75% of participants).
- Trial name
- eSupport (NCT03574961)
- Testing
- e-Support group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Aortic Stenosis
Isolated Surgical Aortic Valve Replacement in Low Risk AS Patients
To establish the safety and effectiveness of surgical aortic valve replacement (SAVR) in patients with isolated severe, calcific aortic stenosis who are at low surgical risk.
- Trial name
- AMETHYST (NCT06924151)
- Testing
- surgical aortic valve replacement, Transcatheter aortic valve replacement
- Where
- 37 sites in Japan
- Volunteers
- 450 people
- Sponsor
- Osaka University
Social Rejection, Attachement Style
Does Attachment Anxiety Moderate the Influence of Social Rejection on Alcohol Use Among Young Adults?
Research shows that heavy drinking patterns are linked to many harmful consequences including death, sexual assault, risky sexual behavior, and drug use.
- Trial name
- PSDCP-2 (NCT07905430)
- Testing
- Social Rejection Feedback, Social Acceptance
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Wilmington
Thorax Injuries, Cervical Injury Spine
The Effect of Sensory Isolation on Anxiety in Magnetic Resonance Imaging
The aim of this study is to determine whether the use of earplugs and eye masks in adults reduces anxiety during Manyetic Resonance Imaging.
- Conditions
- Thorax Injuries, Cervical Injury Spine, Brain Trauma, Joint Trauma
- Trial name
- NCT07155863
- Testing
- Earplugs and eye mask
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ege University
Hepatitis B Vaccination, HIV
HBV Vaccination in HIV-infected Adults
The finding of isolated hepatitis B core antibody (isolated HBc) in absent of recent active hepatitis could cause by several scenarios, including false positive, remote infection without viremia, and occult infection with low…
- Trial name
- NCT03212911
- Testing
- Hepatitis B vaccine
- Where
- Thailand
- Volunteers
- 96 people
- Sponsor
- Chiang Mai University
Caregiver Stress, Social Isolation in Older Adults
Tech-based Respite Care for Caregivers and Homebound Older Adults
The goal of this study is to examine the effectiveness of VR-based respite in improving cognitive function, mental health, and quality of life in caregivers and homebound older adults compared to a control group using videos and…
- Conditions
- Caregiver Stress, Social Isolation in Older Adults, Cognitive Decline in Older Adults, Depression in Older Adults
- Trial name
- TechRespiteRCT (NCT07160673)
- Testing
- VR-based Respite, Video-based Respite
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- Hong Kong University
Atrial Fibrillation, Persistent, Atrial Fibrillation
Clinical Value of Linear Ablation Without Pulmonary Vein Isolation in Persistent Atrial Fibrillation
Based on previous theoretical foundation and clinical practice experience, the investigators further propose a multi-center randomized prospective trial to compare the pure linear ablation strategy without pulmonary vein…
- Trial name
- CLEAR AF II (NCT05468528)
- Testing
- catheter radiofrequency ablation(individualized stepwise linear without pulmonary vein isolation), catheter radiofrequency ablation(PVI)
- Where
- China
- Volunteers
- 207 people
- Sponsor
- China National Center for Cardiovascular Diseases
Melanoma, Sarcoma
Pilot Study of a Double Isolation Perfusion Schedule Using Melphalan Alone for Intransit Melanoma or Unresectable Sarcoma of the Extremity
Hyperthermic isolated limb perfusion with melphalan alone is administered as a double perfusion schedule. These two isolates limb perfusions with melphalan are treated 3-6 weeks apart.
- Trial name
- NCT00001577
- Testing
- double isolated limb perfusion with melphalan alone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Melanoma (Skin)
A Phase I Trial of Normothermic Isolated Limb Infusion (ILI) With Melphalan Plus Buthionine Sulfoximine (BSO) in Patients With Locally Advanced Malignant Melanoma
RATIONALE: Buthionine sulfoximine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of tumor cells…
- Trial name
- NCT00661336
- Testing
- buthionine sulfoximine, melphalan, microarray analysis
- Where
- 2 sites in United States
- Sponsor
- Duke University
Social Isolation, Loneliness
Culture and Well-Being for Latinos
The proposed K23 study is an intervention study using an experimental therapeutics approach. This pilot RCT asks: "Does SOCIAL-ENGAGE increase cultural-social engagement and decrease suicide risk among Spanish-speaking adults?"…
- Conditions
- Social Isolation, Loneliness, Suicidal Ideation
- Trial name
- NCT05244733
- Testing
- Social Engage (S-ENGAGE), The Healthy Lifestyles Education Program
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Rochester
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-regional Digital Health Effort Unlocking the Potential of Artificial Intelligence and Data Science in Health Care
The Clinnova-Multiple Sclerosis (MS) study is part of the Clinnova program (NCT06526364; NCT06235684 and NCT05733702), which seeks to advance precision medicine and the digitalization of healthcare through high-quality…
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive, Clinically Isolated Syndrome, Primary Progressive Multiple Sclerosis
- Trial name
- Clinnova-MS (NCT07280871)
- Testing
- Cohort
- Where
- Luxembourg
- Volunteers
- 100 people
- Sponsor
- Luxembourg Institute of Health
Rheumatoid Arthritis, Psoriatic Arthritis
Research Study on the Immunosuppressive Effects of a Cell Therapy Product on PBMC Isolated From Blood of Patients With Inflammatory Rheumatic Diseases
Rheumatic diseases regroup a variety of disorders affecting the locomotor system including joints, muscles, connective tissues and soft tissues around the joints and bones.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Spondylarthritis
- Trial name
- NCT03454932
- Testing
- Blood sampling
- Volunteers
- 30 people
- Sponsor
- Bone Therapeutics S.A
Multiple Sclerosis
EARLY IFNb-1a and Atorvastatin Combination Therapy of Isolated Clinical Syndrome Suggestive of Multiple Sclerosis
The primary purpose is to determine the changes in gene expression induced by IFNb-1a (Rebif) and atorvastatin (Lipitor) combination therapy in patients with an isolated clinical syndrome suggestive of multiple sclerosis (MS), to…
- Trial name
- NCT00137176
- Testing
- Rebif
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Paroxysmal Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
Pulsed Field Ablation of SVC and PV in Paroxysmal Atrial Fibrillation (PASPA Study)
The PASPA study is a multicenter, randomized trial comparing Pulmonary Vein Isolation (PVI) alone versus PVI plus Superior Vena Cava Isolation (SVCI) using Pulsed Field Ablation (PFA) in patients with paroxysmal atrial…
- Trial name
- PASPA (NCT07191626)
- Testing
- PFA - PV + SVCI, PFA - PVI only
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Multiple Sclerosis
Evaluation of Brain Atrophy in CIS Patients on Avonex
The purpose of this study is To examine if Avaonex can delay the development of clinically definite multiple sclerosis. To investigate if Avonex can delay disability progression by slowing brain atrophy.
- Trial name
- NCT01592474
- Volunteers
- 180 people
- Sponsor
- University at Buffalo
Dystonia
A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia
Stride Dystonia is a randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of VIM0423 in individuals with isolated dystonia.
- Trial name
- NCT07304089
- Testing
- VIM0423
- Where
- 45 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Vima Therapeutics
Atrial Fibrillation, Risk Reduction
Prevention to Improve Outcomes After PVI
Atrial fibrillation (AF) is the most common cardiac arrhythmia and has a rising prevalence due to an aging population. AF increases the patient's risk of hospitalization, heart failure and stroke and results into deterioration of…
- Conditions
- Atrial Fibrillation, Risk Reduction, Nurse's Role
- Trial name
- POP (NCT05148338)
- Testing
- Comprehensive risk factor treatment, Standard of care
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Persistent Atrial Fibrillation
Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation
The purpose of this prospective randomized study is to assess whether empirical Left Atrial Appendage (LAA) isolation along with the standard approach of pulmonary vein isolation (PVI) and ablation of extra-pulmonary triggers is…
- Trial name
- BELIEF (NCT01362738)
- Testing
- RFCA of PV and extra-PV triggers, LAA isolation along with the conventional ablation strategy
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Depression, Loneliness
Empower@Home:Connected - Feasibility and Preliminary Effect Study
This single-group trial will evaluate the feasibility and preliminary effect of a novel group-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Loneliness, Social Isolation, Depressive Disorder
- Trial name
- NCT05732740
- Testing
- Empower@Home:Connected
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Michigan
Enterobacteriaceae Infection
Qnr Genes in Enterobacteriaceae
Enterobacteriaceae are bacteria of the gastrointestinal tract which are also the most frequently involved in bacterial infections, especially urinary tract infections.
- Trial name
- NCT02834910
- Testing
- collection of bacterial sample
- Where
- France
- Volunteers
- 133 people
- Sponsor
- CHU de Reims
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