Clinical trials: Isolation
Atrial Fibrillation
nMARQ™ Pulmonary Vein Isolation System for the Treatment of Paroxysmal Atrial Fibrillation
To demonstrate safety and effectiveness of nMARQ Catheter System [nMARQ] compared with THERMOCOOL® Navigational Family of catheters in treating subjects with drug-refractory symptomatic paroxysmal atrial fibrillation (PAF).
- Trial name
- NCT01824394
- Testing
- nMARQ Navigation Catheters, NaviStar ThermoCool Catheters
- Volunteers
- 481 people
- Sponsor
- Biosense Webster, Inc.
Covid 19, Social Isolation
Community Health Workers Against COVID19
Randomized controlled trial among patients from family practices at risk of psychosocial suffering due to social distancing measures. Patients from the intervention group receive support from community health workers.
- Conditions
- Covid 19, Social Isolation, Mental Health Impairment
- Trial name
- NCT04426305
- Testing
- community health worker support, care as usual
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- University Ghent
Ligament Injury, Knee Injuries
Clinical-instrumental Evaluation and Assessment of Return to Sports Activity in Patients Surgically Treated for Isolated "Stener-like" Lesions of the Medial Collateral Ligament (MCL) or in the Context of Multiligament Injuries and Articular Fractures
The knee is a complex joint stabilized by four main ligaments: the anterior and posterior cruciate ligaments and the medial and lateral collateral ligaments.
- Trial name
- STENER_MCL (NCT07174219)
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Stefano Zaffagnini
Atrial Fibrillation
Marshall Ethanolization, Pulmonary Vein Isolation and Line Completion for Ablation of Persistent Atrial Fibrillation
In ablation strategy for persistent Atrial Fibrillation (PsAF), ablation limited to Pulmonary Vein (PV) isolation is the most straightforward approach but the result give only 50% of arrhythmia free follow-up.
- Trial name
- MARSHALL-PLAN (NCT04681872)
- Testing
- Destruction of Marshall bundles, Pulmonary veins isolation, Linear ablation in the left and right atria
- Where
- 9 sites in Belgium, France
- Volunteers
- 262 people
- Sponsor
- University Hospital, Bordeaux
Loneliness, Elderly (people Aged 65 or More)
Efficacy of a Dog Assisted Group Intervention in Elderly with Unwanted Loneliness
The purpose of this study is to evaluate the efficacy of a dog-assisted group intervention in elderly people with unwanted loneliness; in terms of improving the perception of unwanted loneliness and emotional well-being.
- Conditions
- Loneliness, Elderly (people Aged 65 or More), Animal Assisted Therapy
- Trial name
- AAI (NCT06860412)
- Testing
- Animal Assisted Intervention, Psychoeducational Intervention as Usual
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
SARS-CoV2 Infection, Proximal Tubule Dysfunction
Analysis of SARS-CoV2 Urine Viral Particles and Association With Proximal Tubular Dysfunction
The primary goal is to detect Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV2) urine viral particles in patients in intensive care units, hospitalized for coronavirus Coronavirus Disease-19 (COVID-19) infection, and…
- Trial name
- CovUrinePTD (NCT04937712)
- Testing
- RT-PCR SARS-COV2 in urine
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Central Hospital, Nancy, France
Atrial Fibrillation
Single Chamber Atrial Leadless Pacing for Isolated Sinus Node Dysfunction
The study aims to evaluate the following: 1) the incidence of new onset atrial fibrillation in patients with an atrial leadless pacemaker, 2) the need for upgrade from a standalone atrial leadless pacemaker to a dual chamber…
- Trial name
- NCT07638995
- Testing
- Implantable Loop Recorder
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Healthy Adults, High Altitude
Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
Human milk oligosaccharides (HMOs) are the third-most abundant component in mothers' milk and are an important prebiotic factor for the development of the gut microbiota of infants, promoting the growth of certain beneficial…
- Conditions
- Healthy Adults, High Altitude, Isolation, Social
- Trial name
- NCT06133530
- Testing
- Human milk oligosaccharides, Maltose
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- IU University of Applied Sciences
Neurologic Disorders, Healthy Volunteers
Natural History of Multiple Sclerosis and Its Mimickers
Background: Magnetic resonance imaging (MRI) has been used for decades to help diagnose and monitor neurological disorders like multiple sclerosis (MS). Researchers want to improve how MRI pictures are taken.
- Conditions
- Neurologic Disorders, Healthy Volunteers, Multiple Sclerosis
- Trial name
- NCT02504840
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Squamous Cell Carcinoma of the Head and Neck, Cancer
Study of HLA-DR in Cell Cultures Isolated From Primary Squamous Cell Carcinoma
In our previous study (title: Expression of Major Histocompatibility Complex Molecules class II- HLA-DR in Squamous Cell Carcinoma of the Head and Neck.
- Trial name
- NCT06041464
- Testing
- cell culture
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atrial Fibrillation, Atrial Tachycardia
Empiric Pulsed Field Pulmonary Vein Isolation During Atrial Tachycardia Ablation in Adults With Congenital Heart Disease
This is a prospective, single-arm intervention trial whereby we will test the safety and efficacy of performing pulmonary vein isolation (PVI) using pulsed field ablation (PFA) in adult patients with congenital heart disease…
- Conditions
- Atrial Fibrillation, Atrial Tachycardia, Atrial Flutter, Congenital Heart Disease
- Trial name
- NCT06969378
- Testing
- Pulsed field ablation using a pentaspline ablation catheter
- Sponsor
- Boston Children's Hospital
Atrial Fibrillation (AF)
Atrioventricular Nodal Ablation Versus Pulmonary Vein Isolation - Patient Centred Decisions
The goal of this clinical trial is to compare two procedural approaches to managing atrial fibrillation. The main questions it aims to answer are: Is AF ablation or pacemaker implant and AV nodal ablation a more effective…
- Trial name
- AVENUE PACE (NCT07059208)
- Testing
- Atrioventricular nodal ablation, Pulmonary vein isolation
- Volunteers
- 172 people
- Sponsor
- Sunshine Coast Hospital and Health Service
Atrial Fibrillation
Assessing Arrhythmias After Ablation Using Implantable Recorders
The purpose of this study is to determine if continuous monitoring using an implantable loop recorder (ie. a device that is placed just underneath the skin of the chest and monitors the heart rate and rhythm) for a year long…
- Trial name
- ABACUS (NCT01176617)
- Testing
- Reveal XT implantable loop recorder
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation
Study Comparing Pulmonary Vein Isolation With the Cryoballoon, Radiofrequency Energy, or Both in the Treatment of Atrial Fibrillation (AF)
The purpose of this study is to perform a prospective, randomised study investigating the safety and efficacy of cryoballoon catheter ablation compared with radiofrequency ablation, or both together in the treatment of paroxysmal…
- Trial name
- Cryo Vs RFA (NCT01038115)
- Testing
- Atrial fibrillation ablation
- Where
- United Kingdom
- Volunteers
- 237 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
Sole-Therapy Treatment of Atrial Fibrillation
RESTORE SR II is a feasibility study on the minimally invasive use of the AtriCure Bipolar System for PV Isolation on a beating heart for the treatment of all types of atrial fibrillation in a sole therapy operation (not…
- Trial name
- RESTORE SR II (NCT00566176)
- Testing
- Surgical Ablation using the AtriCure Bipolar System
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- AtriCure, Inc.
Nocturnal Enuresis
Urotherapy vs. Urotherapy With Constipation Treatment for Nocturnal Enuresis
Constipation treatment has been found to ameliorate symptoms in some patients with nocturnal enuresis (bed wetting at night). This study aims to explore if treatment of patients without overt constipation (As defined by the ROME…
- Trial name
- NCT02337413
- Testing
- Polyethylene glycol 3350, Constipation behavioral therapy, Urotherapy
- Where
- Israel
- Sponsor
- Rabin Medical Center
Substance Use Disorders
Substance Use and Loneliness
Background: Loneliness-a subjective emotional state characterized by the perception of social isolation-is a psychosocial factor that is associated with increased mortality, substance use, and is associated with precipitants of…
- Trial name
- NCT05338268
- Testing
- CBT for Loneliness, CBT for Substance Use Disorder
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Persistent Atrial Fibrillation
Circumferential Pulmonary Venous Isolation Combined With Bachmann Bundle Modification Versus Circumferential Pulmonary Venous Isolation for Persistent Atrial Fibrillation
This study is a prospective, randomized controlled, single-blind, multicenter study design. To evaluate the safety and efficacy of traditional pulmonary vein isolation (PVI) alone and PVI combined with Bachmann bundle ablation on…
- Trial name
- NCT07445360
- Testing
- Traditional pulmonary vein isolation (PVI) ablation, Bachmann bundle modification
- Volunteers
- 320 people
- Sponsor
- Shenyang Northern Hospital
Colorectal Neoplasm, Liver Neoplasm
A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver
Patients with unresectable metastatic colorectal cancer confined to the liver will undergo a 1 hour hyperthermic isolated hepatic perfusion (IHP) with escalating dose melphalan.
- Conditions
- Colorectal Neoplasm, Liver Neoplasm, Neoplasm Metastasis
- Trial name
- NCT00001576
- Testing
- Melphalan, Floxuridine, Leucovorin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Cancer Institute (NCI)
Trueness, Intraoral Scanner
Cut-out-Rescan Procedure Under Different Rubber-Dam Isolation
Aim: This clinical study investigated the effect of the "cut-out-rescan" procedure under different rubber dam isolation (blue and black) on restorative scanning trueness of two intraoral scanners.
- Conditions
- Trueness, Intraoral Scanner, Rubberdam, Color
- Trial name
- Cut-out-rescan (NCT06893263)
- Testing
- Taking images from the right lower jaw with an intraoral scanner, Clamp placement on canine and 2nd molar teeth and rubberdam rubber band insertion
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
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