Clinical trials: Isotretinoin
Men with Infertility
13-cis Retinoic Acid (Isotretinoin) and Sperm Production
This study aims to evaluate the effectiveness of weekly administration of isotretinoin (40 mg) in increasing sperm production in men with oligozoospermia, a condition characterized by a low sperm count.
- Trial name
- ARESPERM (NCT06698263)
- Testing
- Isotretinoin
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Optic Disc Swelling
Antiacne Medications Pseudotumor Cerebri
The exact incidence of optic disc swelling and idiopathic intracranial hypertension in patients using antiacne medication is not known so far.
- Trial name
- AAMPTC (NCT02149615)
- Testing
- Retinal nerve fibre layer measurement
- Where
- Switzerland
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Recurrent Neuroblastoma
Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma
This phase II trial is studying how well hu14.18-interleukin-2 (IL2) fusion protein works when given together with sargramostim and isotretinoin in treating patients with relapsed or refractory neuroblastoma.
- Trial name
- NCT01334515
- Testing
- hu14.18-IL2 fusion protein, isotretinoin, sargramostim
- Where
- 76 sites in United States, Canada
- Volunteers
- 52 people
- Sponsor
- Children's Oncology Group
Brain Tumors
Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors
The purpose of this study is to: Find out how safe and effective (by monitoring the good and/or bad effects) treatment with high dose temozolomide, thiotepa and carboplatin with stem cell rescue followed by 13-cis-retinoic acid…
- Trial name
- NCT00528437
- Testing
- temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
- Where
- 17 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- NYU Langone Health
Neuroblastoma
Oral Liquid 13-cis-retinoic Acid (13-CRA)
An open label, randomised, multiple dose, cross-over relative bioavailability and pharmacokinetics trial of a novel oral liquid and capsule formulations of 13-CRA administered to patients from 0 months - < 21 years.
- Trial name
- My-CRA (NCT03291080)
- Testing
- Liquid 13-Cis Retinoic Acid, Extracted capsules 13-CRA
- Where
- 10 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nova Laboratories Limited
Muscle Strength
Effect of Oral Isotretinoin on Muscle Strength in Patients With Acne Vulgaris: A Prospective Controlled Study
BACKGROUND: Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength.
- Trial name
- NCT04626817
- Testing
- Isokinetic device (Biodex System 4)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cevriye Mülkoğlu
Isotretinoin Adverse Reaction, Covid19
Oral Isotretinoin and Covid-19 Infection
There is a theoretical risk that the nasal mucosal dryness caused by oral retinoid medications may increase risk of infection with Covid-19.
- Trial name
- NCT04663906
- Where
- United Kingdom
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Healthy
Bioavailability Study of Isotretinoin Capsules 40 mg Under Fed Condition
To characterise the pharmacokinetic profile of sponsor's test formulation Isotretinoin Capsules 40 mg in comparison to the reference formulation Amnesteem (Containing Isotretinoin) Capsules 40 mg after single oral dose…
- Trial name
- NCT01888224
- Testing
- Isotretinoin
- Where
- India
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Smell Dysfunction
Effects of Isotretinoin on Smell
Isotretinoin is a common medicine used to treat moderate to severe acne. It often causes dryness of the skin and the inside of the nose.
- Trial name
- NCT07309341
- Testing
- isotretinoin
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Uşak University
Neuroblastoma
ch14.18 Pharmacokinetic Study in High-risk Neuroblastoma
The purpose of this study is to compare the pharmacokinetics (blood levels) and safety of chimeric (ch) 14.18 manufactured by two independent drug makers (United Therapeutics [UTC] or the National Cancer Institute [NCI]).
- Trial name
- NCT01592045
- Testing
- ch14.18 -NCI, ch14.18-UTC, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
- Where
- 13 sites in United States
- Volunteers
- 28 people
- Sponsor
- United Therapeutics
Dermatophytosis, Trichophyton Infection
Comparison of Combination of Itraconazole and Isotretinoin Versus Itraconazole Alone in the Treatment of Resistant Trichophyton Infection
Dermatophytosis caused by Trichophyton species is a common superficial fungal infection of the skin, hair, and nails. Increasing reports of persistent or recurrent disease after standard antifungal therapy have raised concern for…
- Conditions
- Dermatophytosis, Trichophyton Infection, Resistant Dermatophyte Infection
- Trial name
- NCT07420894
- Testing
- Itraconazole + Isotretinoin, Itraconazole (ITZ)
- Where
- Pakistan
- Volunteers
- 148 people
- Sponsor
- Multan Medical And Dental College
Kidney Cancer
Interferon Alfa With or Without Isotretinoin in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Interferon alfa may interfere with the growth of the cancer cells and slow the growth of kidney cancer. Isotretinoin may help kidney cancer cells develop into normal cells.
- Trial name
- NCT00002737
- Testing
- recombinant interferon alfa, chemotherapy, isotretinoin
- Where
- 27 sites in Belgium, Hungary and 7 more
- Volunteers
- 320 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Chronic Myeloproliferative Disorders, Leukemia
Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic Syndromes, Thrombocytopenia
- Trial name
- NCT00003619
- Testing
- filgrastim, vitamin E, busulfan
- Where
- 2 sites in United States
- Sponsor
- Drexel University College of Medicine
COVID-19
Isotretinoin in Treatment of COVID-19
Contributors: Lamia Elgarhy, Sabah El-Gaeish 1, Eman Hamed 2 , Wagdy Fathy2 Department of Dermatology, Department of Pharmacology1 , Faculty of Medicine, Tanta University, Department of Chest, Faculty of Medicine, Suez Canal…
- Trial name
- Randomized (NCT04361422)
- Testing
- Isotretinoin Only Product in Oral Dose Form
- Volunteers
- 300 people
- Sponsor
- Tanta University
Neuroblastoma
3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Non-Myeloablative Therapy in Patients With High-Risk Neuroblastoma
The purpose of this study is to find out what effects, good and/or bad, the combination of 3F8 and GM-CSF has on the patient and the cancer. Antibodies are made by the body to attack tumors and to fight infections.
- Trial name
- NCT01183429
- Testing
- 3F8 and 13-cis-retinoic acid
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Drug Toxicity, Lung Cancer
13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer
RATIONALE: 13 Cis retinoic acid may prevent the development of cancer cells. PURPOSE: Randomized double-blinded phase II trial to study the effectiveness of 13-cis retinoic acid with or without vitamin E for chemoprevention or…
- Trial name
- 13-Cis (NCT00002586)
- Testing
- 13-cis retinoic acid, Tocopherol
- Where
- 4 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Colorado, Denver
Prostate Cancer
Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005847
- Testing
- recombinant interferon alfa, estramustine phosphate sodium, isotretinoin
- Where
- 19 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Head and Neck Cancer
Isotretinoin, Interferon Alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy such as isotretinoin use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of tumor cells.
- Trial name
- NCT00054561
- Testing
- recombinant interferon alfa, vitamin E, isotretinoin
- Where
- 89 sites in United States, Australia and 3 more
- Sponsor
- Eastern Cooperative Oncology Group
Lung Cancer
Vitamin E in Preventing the Side Effects of Isotretinoin in Former and Current Smokers Who Are Receiving Isotretinoin to Prevent Lung Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of isotretinoin may be an effective way to prevent lung cancer.
- Trial name
- NCT00003599
- Testing
- Vitamin E (AT), Isotretinoin
- Sponsor
- M.D. Anderson Cancer Center
Acne
Combination Treatment for Moderate to Severe Acne
To determine if a combination of three currently approved acne products are safe and effective for the treatment of moderate to severe acne
- Trial name
- NCT01206348
- Testing
- Minocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
- Where
- 10 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Medicis Global Service Corporation