Clinical trials: Itch
Itch
Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging.
The main objective of this study is to identify by functional and structural MRI which are the brain areas activated in various pruritic situations to deduct a model describing the different causes of pruritus.
- Trial name
- PRURIM (NCT02828787)
- Testing
- MRI
- Where
- 2 sites in France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Itch, Thermal Stimulation
A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing
The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch.
- Conditions
- Itch, Thermal Stimulation, Histamine, Cowhage
- Trial name
- NCT03576053
- Testing
- Lidocaine, Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Morphine, Itch
A Relation of Morphine-induced Itch and Pain Processing
In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch: 1.
- Trial name
- NCT04115462
- Testing
- Morphine, Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Itch
Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch
With this experiment, the experimenter wish to create a new model of itch based on the substance BAM8-22 (Bovine Adrenal Medulla), which is found naturally in the human body and which has proved to evoke itch.
- Trial name
- NCT04197440
- Testing
- BAM8-22 2mg/ml, BAM8-22 1mg/ml, BAM8-22 0.5 mg/ml
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Itch; Athlete
The Mysterious on/Off Itch and Erythema During Whole Body Vibration Exercise
Intense itch on the legs sometimes associated with redness can be adverse effects of whole body vibration (WBV) according to own observations and numerous posts in non-professional online-blogs.
- Trial name
- VIBRA (NCT03455036)
- Testing
- Whole body vibration training
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Itch, Pruritus
The Color of Itch; Itch Modification by Color Viewing
Itch is the commonest skin-related symptom. There is increasing evidence that itch can be influenced by visual cues. The impact of colors on itch has not yet been studied.
- Trial name
- NCT03928223
- Testing
- exploratory survey on Itch modification by color viewing
- Where
- Switzerland
- Volunteers
- 72 people
- Sponsor
- University Hospital, Basel, Switzerland
Itch
Survey on Itch in Outpatients of a University Clinic
This study is to investigate the pruriception (i.e. the perception of the character and intensity of itch), the impact of itch on quality of life, the response to itch and the subjective efficacy and preferences of the different…
- Trial name
- NCT03901443
- Testing
- Survey on itch
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University Hospital, Basel, Switzerland
Tinea Cruris, Jock Itch
Evaluation of Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris
To see how well Naftin 1% cream works when applied once daily to the affected area. The results will be compared to those using a placebo cream, which is a cream with no active ingredient. Safety will also be measured.
- Trial name
- NCT01885156
- Testing
- Naftin 1% Cream
- Where
- 5 sites in Belize, Dominican Republic and 1 more
- Volunteers
- 65 people
- Sponsor
- Merz North America, Inc.
Eczema, Allergy Symptoms
Study to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate Cream
This is a multi-center, open-label study to evaluate whether participants follow the duration of use instructions for short-term use of alclometasone dipropionate in a population of participants with itchy skin conditions who…
- Conditions
- Eczema, Allergy Symptoms, Psoriasis, Itch
- Trial name
- NCT02075632
- Testing
- Alclometasone dipropionate cream
- Volunteers
- 310 people
- Sponsor
- GlaxoSmithKline
Histamine Induced Itch
A Study To Investigate The Effect of JNJ-39758979 on Histamine Induced Itch in Healthy Male Volunteers
The purpose of this study is to investigate the effect of JNJ-39758979 compared to placebo on histamine induced itch in healthy male volunteers.
- Trial name
- NCT01068223
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Individual Adjustment, Itch; Athlete
Electromyographic Analysis And Body Balance In The Use Of Athletes After Cryotherapy By Immersion Ankle
The influence of cryotherapy on ankle motor control and balance of athletes is controversial. The aim of this study is to assess the neuromuscular response of the dominant leg and body balance basketball athletes after…
- Trial name
- NCT01870414
- Testing
- cryotherapy by immersion
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Tinea Cruris, Jock Itch
Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Cruris
A research study to compare the safety and effectiveness of an investigational medication called NAFT-500 to placebo (no active treatment), when used in subjects with tinea cruris, also known as jock itch.
- Trial name
- NCT00750152
- Testing
- NAFT-500
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
ITCH
Aprepitant in the Management of Biological Therapies-related Severe Pruritus
Itch is a common side effect of anti-epidermal growth factor receptor antibodies and tyrosine kinase inhibitors. Investigators designed a pilot single-center phase II study evaluating the effects of Aprepitant, a neurokinin…
- Trial name
- AprepIt (NCT01683552)
- Testing
- Aprepitant, Prednisone, Fexofenadine
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Campus Bio-Medico University