Clinical trials: Ivf
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Oxidative Stress
Sperm Oxidative Stress and Pregnancy Success During IUI and IVF
Oxidative stress (OS) is characterized by an imbalance between the production of reactive oxygen species (ROS) and the ability of the body to eliminate them.
- Trial name
- NCT03539874
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Fertilys
Infertility
Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF)
This study is aimed to demonstrate that highly purified Menotrophin produces significant lower progesterone serum levels during the follicular phase in comparison to Follitropin alpha in the treatment of subfertile females…
- Trial name
- PREDICT (NCT01225835)
- Testing
- Menotrophin, Follitrophin alpha, Cetrorelix
- Where
- 8 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Ferring Pharmaceuticals
Non-obstructive Azoospermia, Male Infertility
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
Objective: To examine the rate of embryo aneuploidy in patients with non-obstructive azoospermia (NOA) who utilize in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and compare live birth rates with the…
- Trial name
- NCT06566599
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility
An Observational Study of Cetrotide® Gonadotropin-releasing Hormone Antagonist (GnRH Antagonist) With GONAL-f® in Assisted Reproductive Technologies (ART)
This is a multicentric, prospective, observational study on the use of Cetrotide to control the endogenous gonadotrophin levels in Gonal-f stimulated ART treatment cycles in the Asia-Pacific region.
- Trial name
- NCT01109654
- Testing
- Cetrorelix acetate and Follitropin alfa
- Where
- Singapore
- Volunteers
- 2,175 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and Assessment
The main purpose of the study was to evaluate the overall clinical value of GERI+ as an integrated embryo culture and assessment system, providing an undisturbed culture environment, continuous monitoring of embryo development…
- Trial name
- TICON (NCT03164551)
- Testing
- GERI+ incubator, Conventional incubator
- Where
- 17 sites in Canada, Denmark and 5 more
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Subfertility
Effect of a Higher Than Maximum 450IU Gonadotropin Dose in an In-vitro Fertilization Cycle
This goal of this study is to evaluate the outcomes from in vitro fertilization cycles where a 450 IU daily dose of gonadotropins is administered compared to those where a 600 IU daily dose is administered for women who are at…
- Trial name
- NCT00971152
- Testing
- menotropins for injection, urofollitropin for injection
- Where
- Canada
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Clinique Ovo
Fertilization in Vitro
Designated Drug Use Investigation 1 of Follistim Injection (Study P06130)(COMPLETED)
To evaluate dosage and administration method, efficacy and safety of Puregon and the relationship between background factors of patients and dose and administration method.
- Trial name
- NCT00920361
- Testing
- Follitropin beta
- Volunteers
- 1,664 people
- Sponsor
- Organon and Co
Women Suffering From Unilateral or Bilateral Tubal Occlusion Due to Hydrosalpinx
Use of Adiana Tubal Occlusive Devices in Women With Hydrosalpinx Prior to In Vitro Fertilization
A condition called hydrosalpinx occurs when one or both of the fallopian tubes is blocked with fluid. The fluid can leak into the tube and the uterus.
- Trial name
- NCT01224080
- Testing
- Adiana placement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Reproductive Science Center
In Vitro Fertilization
Subcutaneous Progesterone Versus Vaginal Progesterone Tablets for Luteal Phase Support in In Vitro Fertilization (IVF)
Prospective, open, randomized, parallel, multicenter, two-arm trial to evaluate the efficacy and tolerability of a new progesterone formulation to be used for luteal support in IVF (Progesterone-IBSA) administered subcutaneously…
- Trial name
- NCT00828191
- Testing
- Progesterone
- Where
- 8 sites in United States
- Volunteers
- 800 people
- Sponsor
- IBSA Institut Biochimique SA
Infertility
Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Indian Women
To demonstrate non-inferiority of FE 999049 compared with GONAL-F with respect to ongoing pregnancy rate in women undergoing controlled ovarian stimulation.
- Trial name
- IRIS (NCT04773353)
- Testing
- Follitropin Delta (FE 999049), Follitropin Alfa (GONAL-F)
- Where
- 12 sites in India
- Volunteers
- 220 people
- Sponsor
- Ferring Pharmaceuticals
Women Who Suffer From Hydrosalpinx That is Causing Infertility and Whom Want a Safer Way of Treamtent
Use of Essure® Micro-inserts in Women With Hydrosalpinx Prior to In Vitro Fertilization: A Prospective, Multicenter, International Feasibility Study
The purpose of this study is to gather safety data related to the use of Essure® micro-inserts in women with hydrosalpinx prior to in vitro fertilization and during pregnancy and to collect data with regard to implantation rates…
- Trial name
- NCT01221974
- Testing
- Essure Micro Insert
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Reproductive Science Center
Infertility
Efficacy and Safety Study of a Single Injection of SCH 900962 Versus Daily recFSH Injections in Women Undergoing Controlled Ovarian Stimulation (Study P06029)
The purpose of this study is to show that a single injection of SCH 900962/MK-8962 is non-inferior to daily injections of recombinant follicle-stimulating hormone (recFSH) during the first week of ovarian stimulation in terms of…
- Trial name
- PURSUE (NCT01144416)
- Testing
- SCH 900962 / Corifollitropin alfa / Org 36286, RecFSH / follitropin beta
- Volunteers
- 1,424 people
- Sponsor
- Organon and Co
Infertility
A Study to Evaluate the Baseline Follicle Stimulating Hormone, Ovarian Volume and Antral Follicle Count as Prognostic Factors of the Outcome of In-vitro Fertilisation/Intracytosolic Sperm Injection in Infertile Patients Receiving Gonal f for Controlled Ovarian Hyperstimulation
This is a phase IV non-interventional, multicentric observational study to evaluate the baseline follicle stimulating hormone (FSH) levels, ovarian volume, antral follicle count (AFC) and age as prognostic factors of the outcome…
- Trial name
- NCT01196143
- Where
- Greece
- Volunteers
- 356 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pregnancy, Neonates
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial 38833 (P05783)
The objective of this trial is to evaluate whether corifollitropin alfa (MK-8962, Org 36286) treatment for the induction of multifollicular growth in women undergoing Controlled Ovarian Stimulation (COS) prior to in vitro…
- Trial name
- Care (NCT00702520)
- Testing
- Corifollitropin alpha (MK-8962, Org 36286) 100 ug, Corifollitropin alpha (MK-8962, Org 36286) 150 ug, Triptorelin
- Volunteers
- 15 people
- Sponsor
- Organon and Co
In Vitro Fertilization
A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)
To investigate the efficacy and safety of a single injection of 150 μg Corifollitropin Alfa (Organon 36286) to induce multifollicular development for controlled ovarian stimulation using daily recombinant FSH (recFSH) as a…
- Trial name
- NCT00696800
- Testing
- Corifollitropin alfa, RecFSH / Follitropin beta (Days 1 to 7), RecFSH / Follitropin beta (Days 8 to hCG)
- Volunteers
- 1,509 people
- Sponsor
- Organon and Co
Infertility, Female, Infertility
Phase II Clinical Trial to Evaluate the Ongoing Pregnancy Rate With OXO-001 in IVF/ICSI With Donor Oocytes.
The main objective of this clinical research trial is to test the efficacy of OXO-001 in a daily oral administration increasing the pregnancy rate in IVF/ICSI by preparing the uterus to receive the embryo.
- Trial name
- OXOART2 (NCT05076032)
- Testing
- OXO-001
- Where
- 28 sites in Czechia, Poland and 1 more
- Volunteers
- 408 people
- Sponsor
- OXOLIFE
Fertility Disorders
Natural Frozen Embryo Transfer (FET) vs Substituted Frozen Embryo Transfer (FET)
In frozen embryo transfer substituted cycles, patients are treated with progesterone and estrogen in an attempt to mimic the natural cycle and a transfer is planned whenever the endometrium is ready.
- Trial name
- NCT06053827
- Testing
- Frozen embryo transfer
- Where
- Canada
- Volunteers
- 1,207 people
- Sponsor
- Clinique Ovo
In Vitro Fertilization
A Trial of Single Dose Corifollitropin Alfa's Ability to Induce Multiple Follicular Growth During the First Week of Controlled Ovarian Stimulation for IVF or ICSI (38833)(P05788)
To evaluate the induction of multiple follicular growth after single dose administration of 100 μg or 150 μg Org 36286 in a long protocol of GnRH agonist.
- Trial name
- Realize (NCT00702351)
- Testing
- Org 36286 (corifollitropin alfa)
- Volunteers
- 50 people
- Sponsor
- Organon and Co
Controlled Ovarian Stimulation
Study to Assess the Design of Use of REKOVELLE® in Women Undergoing In Vitro Fertilisation or Intracytoplasmic Sperm Injection Procedures in Routine Clinical Practice
The aim of the study is to explore how the individualized dosing regimen of REKOVELLE is used in routine clinical practice and to describe the effectiveness and safety of REKOVELLE under real-world conditions.
- Trial name
- DELTA (NCT04503707)
- Testing
- Follitropin Delta
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Ferring Pharmaceuticals