Clinical trials: Ivf
Infertility, Female
Baseline and First Trimester Uterine Artery Doppler Velocimetry to Predict Poor Obstetric Outcomes in IVF
The researchers aim to determine how baseline (preconceptional) and first-trimester uterine artery Doppler measurements affect obstetric complications in women undergoing high-quality blastocyst transfer and to determine the…
- Trial name
- NCT05661539
- Testing
- Transvaginal Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Akdeniz University
Preimplantation Diagnosis
RCT of niPGT for Aneuploidy and Morphology Compared With Morphology Alone in IVF
This study is to compare the efficacy in embryo selection based on morphology alone compared to morphology and non-invasive preimplantation genetic testing for aneuploidy (NIPGT-A) in infertile women undergoing in vitro…
- Trial name
- NCT04474522
- Testing
- Non-invasive Preimplantation genetic testing for aneuploidy status
- Where
- China
- Volunteers
- 517 people
- Sponsor
- The University of Hong Kong
Polycystic Ovary Syndrome
Recombinant Versus Highly Purified FSH in Polycystic Ovary Syndrome (PCOS)
Control ovarian stimulation responses, pregnancy and miscarriage rates are indifferent when either recombinant or highly purified follicle stimulating hormone (FSH) is used.
- Trial name
- NCT01337531
- Testing
- Gonal-F, Fostimon
- Where
- Cyprus
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genesis Center for Fertility & Human Pre-Implantation Genetics
Infertility; In Vitro Fertilization; Embryo Development
Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes
This randomized controlled trial compared assisted hatching (AH) performed on Day 3 versus Day 5 in patients undergoing IVF-ICSI with preimplantation genetic testing for aneuploidy (PGT-A).
- Trial name
- AH-PGTA (NCT07154875)
- Testing
- Laser-Assisted Hatching
- Where
- Vietnam
- Volunteers
- 141 people
- Sponsor
- Hoang Minh Ngan
In Vitro Fertilization, Male Factor Infertility
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility?
The purpose of this study is to determine the impact of the use of calcium ionophore on the ICSI outcomes in couples with severe male factor infertility.
- Trial name
- NCT02992665
- Testing
- Ca Ionophore A23187
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Infertility, Female
Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment
The number of children conceived by assisted reproductive technology is increasing in Nordic countries as well as worldwide. An important factor of success in treatment of infertility is a short "time to pregnancy" with impact on…
- Trial name
- NCT01882166
- Testing
- fostimon, puregon
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Infertility Assisted Reproductive Technology
Difference Between Progestin Primed Ovarian Stimulation Protocol and Antagonist Protocol
compare the effectiveness and safety of the progestin primed ovarian stimulation (PPOS) protocol versus the antagonist protocol in hyper-responder patients scheduled for a freeze-all policy
- Trial name
- NCT06738602
- Volunteers
- 270 people
- Sponsor
- Assiut University
Patient Education
Preimplantation Genetic Testing for Aneuploidy Counseling
Purpose: To evaluate preimplantation genetic testing counseling interventions on patients undergoing in vitro fertilization treatment.
- Trial name
- PGT-A (NCT06018454)
- Testing
- Handout on PGT-A, Handout on PGT-A and genetic counseling
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Eyup Hakan Duran
IVF, Infertility
The Rate of Embryo Euploidy in Progestin-primed Ovarian Stimulation Cycles
The main objective of this non-inferiority randomized controlled trial is to assess the rate of blastocyst euploidy and the number of euploid blastocysts in women undergoing IVF/ICSI and treated with PPOS versus conventional…
- Trial name
- PPOS (NCT04654741)
- Testing
- Medroxyprogesterone Acetate, Ganirelix Acetate
- Where
- Italy
- Volunteers
- 396 people
- Sponsor
- Casa di Cura Privata Villa Mafalda
Increase Pregnancy Rate
Triggering of Follicular Maturation
The follicular phase of the menstrual cycle involves the hourly release of gonadotropin-releasing hormone, which binds to receptors on the gonadotropes.
- Trial name
- NCT02916173
- Testing
- Recombinant Human Chorionic Gonadotrophin, human chorionic gonadotrophin + gonadotrophin releasing hormone agonist
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Assiut University
IVF Outcomes
Comparison of Two Protocols in Frozen Embryo Transfer
This randomized clinical trial evaluates two different endometrial preparation protocols-hormone replacement therapy (HRT) and natural cycle-for frozen embryo transfer (FET) in infertile women undergoing assisted reproductive…
- Trial name
- NCT07003373
- Testing
- hormone replacement therapy (HRT) group
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Malihe Mahmoudinia
Embryo Hypoxia
The Effect of Low Oxygen Tension on the Early Development of Human Embryo in IVF/ICSI
To investigate the effect of low oxygen tension during in vitro culture in terms of embryo quality and outcomes of pregnancy in vitro fertilization/ Intracytoplasmic sperm injection
- Trial name
- NCT01983696
- Testing
- 5% oxygen concentration
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanxi Provincial Maternity and Children's Hospital
Polycystic Ovary Syndrome (PCOS), Female Infertility
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
- Trial name
- PPOS-PCOS-IVF (NCT07394530)
- Testing
- Progestin-Primed Ovarian Stimulation (PPOS), GnRH Antagonist Protocol
- Where
- Vietnam
- Volunteers
- 400 people
- Sponsor
- Hanoi General Hospital (Vietnam)
Infertility (IVF Patients)
The Role of hCG in Thawed Embryo Transfer
This prospective randomized trial will assess the relevance, if any, of a corpus luteum induced by hCG in transfers of thawed embryos.
- Trial name
- NCT07004192
- Testing
- HCG injection, No intervention
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Infertility, Female
Heated and Non Heated Ovarian Aspiration Needle Protocol
The success of IVF is influenced by factors as cause of infertility and age. Furthermore, there is a large influence of external factors, from the laboratory environment, handling and cultivation of gametes and embryos.
- Trial name
- NCT05683639
- Testing
- warming of the follicular aspiration needle
- Where
- Brazil
- Volunteers
- 179 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Fertilization in Vitro
Interest of Audiovisual Distraction in the Management of Anxiety and Pain During Oocyte Retrieval
Oocyte retrieval procedure for in vitro fertilization is a source of anxiety for patients. Local anaesthesia or sedation are commonly used to manage many situations of anxiety, including the oocyte retrieval.
- Trial name
- Happy-Fiv (NCT04213781)
- Testing
- HappyMed Video Glasses, Propofol, Sufentanil
- Where
- France
- Volunteers
- 36 people
- Sponsor
- CMC Ambroise Paré
Infertility
Gynecologists' Feedback on ART-Birth Rates
The investigators will examine the hypothesis that women who are given their personalized IVF-prognosis are less likely to overestimate their IVF-live birth rate, as compared to women who do not receive a personalized…
- Trial name
- GAB-RCT (NCT04169295)
- Testing
- Gynecologists' feedback on ART-Birth rates, Control group
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Infertility
GnRH for Luteal Support in IVF/ICSI/FET Cycles
During IVF cycles an embryo is generally placed into the uterine cavity between 3 and 5 days after fertilization. For a successful pregnancy to take place, that embryo must then implant in the properly primed and staged…
- Trial name
- NCT02357654
- Testing
- GnRH
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University Reproductive Associates
Sterility
To Investigate the Cumulative Live Birth Rates Using GnRH Antagonist or Agonist Protocol for COS in ART Treatment
This is a Phase IV, prospective, randomized controlled study to investigate the cumulative live birth rates (CLBRs) of gonadotrophin-releasing hormone (GnRH) antagonist protocol (GnRH-ant group) compared with the standard GnRH…
- Trial name
- CLBR (NCT04026282)
- Testing
- GnRH-ant protocol, GnRH-a long protocol
- Where
- 4 sites in China
- Volunteers
- 888 people
- Sponsor
- Peking University Third Hospital
Reproductive Techniques, Assisted, Artificial Intelligence
Retrospective Evaluation Blastocyst Development by Artificial Intelligency
In assisted reproductive technology (ART), selecting the most viable embryos from a large number of fertilized eggs is crucial. While techniques like morphological assessment, time-lapse monitoring systems, and pre-implantation…
- Conditions
- Reproductive Techniques, Assisted, Artificial Intelligence, Embryo Transfer
- Trial name
- EBAI (NCT07383480)
- Where
- France
- Volunteers
- 333 people
- Sponsor
- University Hospital, Clermont-Ferrand
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