Clinical trials: Ivf, open to volunteers
Pre-Eclampsia
At High-risk for Pre-eclampsia After Assisted Reproductive Technology
The overarching goal of the project is to unravel PE etiopathogenesis in high-risk patients (PCOS patients and oocyte acceptors) after assisted reproductive technology (ART) to individualize prenatal care following ART and to…
- Trial name
- HEART (NCT05746793)
- Testing
- endometrium biopsy, Transabdominal ultrasound, Peripheral phlebotomy
- Where
- Belgium
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
IVF, Endometrioma
Endometrioma Ethanol Sclerotherapy - Prospective Cohort Study Protocol
Ovarian endometriomas are cystic masses lined with endometrial tissue that contains fluid arising from a collection of menstrual debris.
- Trial name
- NCT06971458
- Testing
- Sclerotherapy
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Hillel Yaffe Medical Center
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Infertility, Microplastics Exposure
Fertility Impact of Microplastics - Advancing Countermeasures and Tracking
FERTIMPACT is a prospective clinical study based on the hypothesis that exposure to micro- and nanoplastics (MNPs) is associated with impaired reproductive function.
- Conditions
- Infertility, Microplastics Exposure, Fertility
- Trial name
- FERTIMPACT (NCT07562958)
- Volunteers
- 1,000 people
- Sponsor
- University of Kragujevac
Infertility, Female
Efficacy and Safety of Gushen Antai Pill on Ongoing Pregnancy Rate in Women With Normal Ovarian Reserve Undergoing IVF-ET
The purpose of this study is to investigate whether oral Gushen Antai pills supplementation for luteal phase support will improve ongoing pregnancy rate in women with normal ovarian reserve in fresh embryo transfer cycles.
- Trial name
- GSATP-FreET (NCT04872660)
- Testing
- Gushen Antai Pill
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility (IVF Patients)
Study of Abnormally Fertilized Embryos
The goal of this observational study is to determine the diploidy rate of haploid and triploid embryos from in vitro fertilization (IVF) cycles.
- Trial name
- SAFE (NCT06940973)
- Testing
- Parental samples, PGT-A, TE rebiopsies and spent blastocyst media collection
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Igenomix
In Vitro Fertilization
Effect of Super-GDF9 on CAPA-IVM of COCs From Small Antral Follicles
CAPA-IVM (In Vitro Maturation) technology is an assisted reproductive method offering significant benefits in terms of safety and treatment costs, particularly for high-risk patients.
- Trial name
- sGDF-9 (NCT06766604)
- Testing
- Super-GDF9 supplementation during CAPA-IVM, Conventional CAPA-IVM
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Mỹ Đức Hospital
Infertility, IVF
Immediate Versus Postponed Single Blastocyst Transfer in Programmed or Stimulated Cycle Frozen Embryo Transfer
The aim of this randomized controlled trial is to examine whether single blastocyst transfer in the first cycle after oocyte retrieval (immediate) is non-inferior to single blastocyst transfer in a subsequent cycle (postponed) in…
- Trial name
- NCT06304792
- Testing
- Immediate FET in a stimulated or programmed cycle
- Where
- Denmark
- Volunteers
- 484 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Hypo-responder, Infertility (IVF Patients)
Optimal Stimulation of Hypo-responders Undergoing in Vitro Fertilization (IVF)
Stimulation is a key step of in vitro fertilization (IVF). Typically, injectable gonadotropins are used for stimulation, and their dose is individually determined to avoid hypo- as well as hyper-response.
- Conditions
- Hypo-responder, Infertility (IVF Patients), OVARIAN STIMULATION
- Trial name
- NCT07121751
- Testing
- use of combination of recombinant FSH and recombinant LH, higher dose recFSH, unchanged dose
- Where
- 4 sites in Hungary
- Volunteers
- 150 people
- Sponsor
- Dunamenti REK Istenhegyi IVF Center
Oocyte Retrieval, Adverse Events
The Use of Virtual Reality Technology During Oocyte Retrieval for in Vitro Fertilization
Ultrasound-guided oocyte retrieval (OR) is a short, but oftentimes painful procedure, during which the follicles are punctured trans-vaginally to obtain oocytes for in vitro fertilization (IVF).
- Conditions
- Oocyte Retrieval, Adverse Events, Procedural Anxiety, Pain Intensity
- Trial name
- NCT06733701
- Testing
- VR-based intervention (VRReliever Software V0.3.4 fromXRHealth), VR headset without any scenery
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Repeated IVF Failure, Microbiota
The Role of the Physiological Endometrial Microbiota in Assisted Reproduction Outcomes
The goal of this observational study is to investigate the influence and contribution of the normal composition and balance of the endometrial microbiota on the achievement of embryo implantation and the maintenance of pregnancy…
- Trial name
- no exist (NCT07606053)
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Assisting Nature
Preterm Birth
Prolonged Progesterone to Prevent Preterm Birth From IVF - ET
To investigate the incidence of preterm birth in IVF fresh embryo transplantation cycle patients after prolonged vaginal progesterone treatment
- Trial name
- NCT05787509
- Testing
- Progesterone Sustained-release vaginal gel
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility, Female
Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro…
- Trial name
- NCT06701071
- Testing
- Clomiphene Citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Recurrent Implantation Failure, Endometrial Receptivity Disorders
Experimental Study on the Use of Intrauterine Infusion of Autologous Platelet-rich Plasma (PRGF-IUI) in Patients With Recurrent Implantation Failure and/or Refractory Thin Endometrium
Endometrial receptivity is a key determinant of success in assisted reproductive technology (ART). A significant proportion of patients experience repeated implantation failure despite euploid embryos and adequate laboratory…
- Conditions
- Recurrent Implantation Failure, Endometrial Receptivity Disorders, Embryo Implantation, Platelet-Rich Plasma
- Trial name
- PMA_PREPAIRE (NCT07455773)
- Testing
- Intrauterine Platelet-Rich Plasma (PRP) Infusion, Hormone Replacement Therapy (HRT)
- Volunteers
- 80 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Infertility Assisted Reproductive Technology
Difference Between Progestin Primed Ovarian Stimulation Protocol and Antagonist Protocol
compare the effectiveness and safety of the progestin primed ovarian stimulation (PPOS) protocol versus the antagonist protocol in hyper-responder patients scheduled for a freeze-all policy
- Trial name
- NCT06738602
- Volunteers
- 270 people
- Sponsor
- Assiut University
Advanced Age, Recurrent Pregnancy Loss(RPL)
Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer
Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss.
- Conditions
- Advanced Age, Recurrent Pregnancy Loss(RPL), Infertility (IVF Patients), Sequence Analysis
- Trial name
- NICSAI-SBT-RCT (NCT07461077)
- Testing
- NICS-AI, Morphology group
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Unexplained Infertility
ICSI Versus Conventional IVF in Couples With Unexplained Infertility
This multicenter, open-label, parallel-group, randomized controlled trial aims to compare the live birth rate, fertilization outcomes, other pregnancy outcomes and safety between ICSI and conventional IVF among couples with…
- Trial name
- ICSI/IVF-UI (NCT07294027)
- Testing
- ICSI, IVF
- Where
- 7 sites in China
- Volunteers
- 848 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Infertility, Female, Infertility, Male
Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.
- Conditions
- Infertility, Female, Infertility, Male, Infertility, IVF
- Trial name
- NCT06419127
- Testing
- Timelapse incubation and PGT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Gattaca Genomics