Clinical trials: Ivf
In-vitro Fertilization
Combination of Gonadotropin-releasing Hormone Agonist and Human Chorionic Gonadotropin Triggered by Normal Responder in GnRH-antagonist Cycles
Background The trigger for the final maturation of the ovum by providing integration of Human Chorionic Gonadotropin (hCG) and Gonadotropin - releasing hormone (GnRH) agonist was first introduced long ago, but clinically not…
- Trial name
- NCT02862782
- Testing
- hCG (Ovitrelle 250 mcg mcg - Merck Serono), hCG (Ovitrelle 250 mcg mcg - Merck Serono) + GnRH agonist (Decapeptyl 0.2mg - Ferring Gmgh)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Infertility
Physiotherapy in Assisted Reproductive Treatment
Research examines the effect of physiotherapy on treatment success by assisted reproductive technologies. It is based on a treatment of infertility by physiotherapeutic intervention after which the participants will undergo a…
- Trial name
- NCT04971824
- Testing
- Physiotherapeutic intervention
- Where
- Czechia
- Volunteers
- 42 people
- Sponsor
- Klaudia Fabičovic, PT
Progesterone, Luteal Phase Support
Patient's Preferences About Subcutaneous or Vaginal Progesterone Administration for Luteal Phase Support
Luteal phase support in "in vitro fertilization" (IVF) cycles has been shown to improve pregnancy rates and became a standard of treatment, and progesterone is the first choice considering its safety profile and effectiveness.
- Conditions
- Progesterone, Luteal Phase Support, In Vitro Fertilization
- Trial name
- PROPER-1 (NCT03734770)
- Testing
- Subcutaneous Progesterone, Vaginal progesterone
- Where
- Italy
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Infertility (IVF Patients)
Correlation of the Genetic Constitution of the Spent Blastocyst Media
The main objective of this study is to improve niPGT-A (non-invasive Preimplantation Genetic Testing for Aneuploidies) to avoid the need of a biopsy to perform the genetic analysis of the embryo and to help in understanding the…
- Trial name
- CONNECTED (NCT06780605)
- Testing
- niPGT-A, Multifocal TE biopsies and ICM biopsy
- Where
- 2 sites in Cyprus
- Volunteers
- 230 people
- Sponsor
- Igenomix
Unexplained Infertility
Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertility
Based on available evidence and given the potential beneficial effects of resveratrol in folliculogenesis and in oocyte development, the investigators designed a randomized, controlled, double-blind, single-center trial, whose…
- Trial name
- RECOS (NCT06481696)
- Testing
- Resveratrol-based multivitamin supplement, Folic acid, IVF/ICSI
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Andros Day Surgery Clinic
Infertility, Female, Pregnancy Related
Low TGF-β and Embryo Implantation in the Context of Assisted Reproductive Technology: Confirmation of a Biomarker Predictive of Success and Characterization of the Immune Microenvironment.
Infertility affects about one in seven couples in France. Beyond the medical and personal challenges, it has major societal implications.
- Trial name
- ImmuNoFertilit (NCT07859930)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Infertility, Infertility, Female
How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells
To develop a deeper understanding of endometrial-embryo crosstalk through basic research, uncover therapeutic targets and to improve reproductive outcome.
- Conditions
- Infertility, Infertility, Female, Aneuploidy
- Trial name
- Ca2+ (NCT04865367)
- Testing
- Exposure to culture media
- Where
- United Arab Emirates
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
PCOS, IVF
IVM Versus IVF in High Antral Follicle Count Patients
In vitro maturation (IVM) is postulated to be an alternative to conventional in vitro fertilization (IVF) to avoid ovarian hyperstimulation syndrome.
- Conditions
- PCOS, IVF, IVM
- Trial name
- NCT03405701
- Testing
- IVM, IVF
- Where
- Vietnam
- Volunteers
- 546 people
- Sponsor
- Mỹ Đức Hospital
Infertility, Infertility, Female
Assessing Ketorolac (Toradol) at Oocyte Retrieval
To determine if a nonsteroidal anti-inflammatory drug (NSAID), Ketorolac (Toradol), can improve pain control and decrease narcotic use after undergoing egg retrieval.
- Conditions
- Infertility, Infertility, Female, Oocyte Retrieval, Postoperative Pain
- Trial name
- Alleviate (NCT06026553)
- Testing
- Ketorolac (Toradol)
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
IVF - Luteal Phase Support After Embryo Transfer
A Prospective Randomized Multicentre Study to Compare Crinone 8% Once Daily Versus Other Vaginal Progesterone.
To compare the effect of Crinone 8% administered once daily versus other vaginal progesterone in terms of ongoing pregnancy rate 5 weeks after embryo transfer as well as patient convenience.
- Trial name
- NCT00708539
- Testing
- progesterone
- Where
- 17 sites in Denmark, Sweden
- Volunteers
- 2,686 people
- Sponsor
- Nordica Fertility Clinic
Obesity
Effect of Hypocaloric Diet and Exercise in Obese Women Who Are Subjected to IVF Cycle
The purpose of this study is to determine the impact of diet and physical exercise program on pregnancy rate and live birth in obese women who undergo an IVF cycle.
- Trial name
- NCT01952795
- Testing
- Diet and exercise
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Infertility
Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos
Human embryos can be preserved for later transfers by freezing. Traditionally the slow cooling method has been used. About 70% of the embryos remain fully intact after thawing.
- Trial name
- NCT00886431
- Testing
- embryo vitrification
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility, Female
Heated and Non Heated Ovarian Aspiration Needle Protocol
The success of IVF is influenced by factors as cause of infertility and age. Furthermore, there is a large influence of external factors, from the laboratory environment, handling and cultivation of gametes and embryos.
- Trial name
- NCT05683639
- Testing
- warming of the follicular aspiration needle
- Where
- Brazil
- Volunteers
- 179 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Depression, Anxiety
The Effect of Selective Serotonin Reuptake Inhibitor (SSRI) Treatment on Affective Symptoms and Fertility Treatment Outcome in Women Undergoing in Vitro Fertilization (IVF)
Women undergoing IVF show a high prevalence of depressive and anxiety symptoms. Furthermore, stress has harmful consequences on IVF and pregnancy outcomes. An immunological cascade was suggested to be involved in the process.
- Conditions
- Depression, Anxiety, In Vitro Fertilization
- Trial name
- NCT00989053
- Testing
- escitalopram
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Luteal Phase Defect
Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support
The purpose of this study is to compare efficacy and tolerability of the dydrogesterone and the vaginal progesterone, used for luteal phase support.
- Trial name
- NCT01178931
- Testing
- Oral dydrogesterone, Crinone 8% gel
- Where
- Croatia
- Volunteers
- 853 people
- Sponsor
- University of Zagreb
Egg Donation, Infertility Assisted Reproductive Technology
Egg Donation at the Assisted Reproductive Technology (ART) Center of the Nancy University Hospital
Since the 2021 revision of French bioethics laws, access to assisted reproductive technologies (ART) has expanded, leading to a significant increase in gamete donation requests.
- Trial name
- DONOVO-Nancy (NCT07468331)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Infertility
The Effect of Interactive Music Therapy Applied for Women During the Perioperative Period for IVF on Their Stress Levels
The purpose of this study is to investigate the effect of music therapy on stress levels in female patients applying for in vitro fertilization.
- Trial name
- IVF (NCT06117202)
- Testing
- music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Uludag University
Infertility
Anti-Mullerian Hormone (AMH) Versus Antral Follicle Count (AFC) Guided rFSH Dosing Study
The overall objectives of this trial are to: To explore the efficacy and safety of using either antral follicle count (AFC) or anti-Mullerian hormone (AMH) to guide the starting dose of GONAL-f® in ovarian stimulation for…
- Trial name
- NCT01783301
- Testing
- FSH
- Where
- Vietnam
- Volunteers
- 348 people
- Sponsor
- Vietnam National University
Idiopathic Ventricular Fibrillation, Cardiac Arrest, Out-Of-Hospital
MEdical Treatment in Idiopathic Ventricular Fibrillation Patients
A person who has experienced a cardiac arrest with no apparent cause is at risk of having recurrent cardiac arrest. Hence an implantable cardioverter-defibrillator (ICD) is recommended on empirical grounds.
- Trial name
- RIME-IVF (NCT07405229)
- Testing
- Beta-blocker treatment group
- Where
- 2 sites in Denmark
- Volunteers
- 218 people
- Sponsor
- Bo Gregers Winkel
Infertility
Low-dose GH Supplementation Increases Clinical Pregnancy Rate
The objective of this study is to assess whether a low dose of GH supplementation (0.5 IU/day) increases clinical pregnancy rates in women with a history of POR who failed to become pregnant in two previous IVF cycles.
- Trial name
- NCT02359695
- Testing
- Growth Hormone
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Centro de Infertilidad y Reproducción Humana
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