Clinical trials: Ivf
Infertility
Metabolomics Non Selection Study - Vitrolife Media
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04976920
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Overture Life
Infertility
Sequential vs. Monophasic Media Impact Trial (SuMMIT)
To evaluate the impact of two FDA approved culture media on potential of human embryos resulting from IVF (sequential \& monophasic media).
- Trial name
- SuMMIT (NCT01917240)
- Testing
- Comprehensive Chromosome Screening
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Female Infertility
Recombinant Follicle-stimulating Hormone in Treatment for Infertility
This is a randomized multi-centre, assessor-blind, parallel-group study to be conducted in 250 women in the age group of 20 to 39 years (both inclusive), who are indicated to undergo COS as part of assisted reproductive…
- Trial name
- REFRESH (NCT05266924)
- Testing
- Recombinant Human Follicle Stimulating Hormone 900 IU (66.0 μg) / 1.5mL Solution for Injection in Prefilled Pen
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Bharat Serums and Vaccines Limited
Subfertility
Endometrial Scratching in In Vitro Fertilization Cycles With Oocyte Donation
This study is designed to evaluate the potential benefit in pregnancy rates produced by an endometrial scratching made in an IVF cycle prior to embryo transfer in patients with donated oocytes.
- Trial name
- NCT01842178
- Testing
- scratching
- Where
- Spain
- Sponsor
- Centro de Infertilidad y Reproducción Humana
Pregnancy Outcome After In Vitro Fertilization (IVF)
Progesterone Rise in Agonist Versus Antagonist in Vitro Fertilization (IVF) Cycles
The aim is to explore whether the incidence of progesterone rise in the late follicular phase differs between GnRH-agonist and GnRH-antagonist protocols for IVF and whether this has an impact on the probability of pregnancy…
- Trial name
- NCT01191710
- Testing
- In vitro fertilization
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Male, DNA Damage
Testicular Versus Ejaculated Spermatozoa for IVF/ICSI in Men With High Sperm DNA Damage
The purpose of this study is to determine whether couples undergoing IVF/ICSI with male factor infertility, specifically with elevated sperm DNA damage, should testicular sperm extraction be utilized to improve their reproductive…
- Trial name
- NCT02058082
- Testing
- Intracytoplasmic sperm injection
- Volunteers
- 25 people
- Sponsor
- Mount Sinai Hospital, Canada
Infertility
Swanson-Based Supportive Care for Infertility Stress and Coping in Couples Undergoing ART
The goal of this clinical trial is to learn if supportive care based on Swanson's Caring Theory can reduce stress and improve coping in couples undergoing infertility treatment with assisted reproductive treatment (ART)…
- Trial name
- NCT07557069
- Testing
- Swanson Caring Theory-based supportive care
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ondokuz Mayıs University
Infertility
Outcomes of Couples After Failed PGD Management: A Single-Center Study at the Paris PGD Center (Antoine Béclère - Necker)
Preimplantation genetic testing (PGT) is a reproductive genetic technique aimed at preventing the transmission of severe genetic disorders.
- Trial name
- DECOPI (NCT07371312)
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polycystic Ovarian Syndrome (PCOS), Patients Sensitive to Exogenous Gonadotropins
In Vitro Maturation (IVM) of Human Oocytes
We hypothesize that the combination of natural cycle IVF or low dose gonadotropin injection combined with In Vitro Maturation (IVM) (Natural IVF/IVM) is a viable option for a selected population of infertility patients who cannot…
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Patients Sensitive to Exogenous Gonadotropins, Ovarian Hyper Stimulation Syndrome (OHSS)
- Trial name
- IVM (NCT01843569)
- Testing
- In Vitro maturation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Infertility, Assisted Reproductive Technology
Does the Embryo Transfer Technique Affect the Success of in Vitro Fertilization?
Prospective, open, randomized, parallel, two-arm trial to compare the clinical pregnancy rate between most commonly used two embryo transfer techniques: trial followed by transfer technique and afterloading technique
- Conditions
- Infertility, Assisted Reproductive Technology, IVF
- Trial name
- NCT03756857
- Testing
- Afterload Transfer, Trial followed by transfer
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Acibadem Kadiköy Hospital
Reproductive Performance Following Ovarian Transplantation
Transplantation of Frozen Thawed Ovarian Tissue High Reproductive Performance
Design: prospective cohort study. Setting: Tertiary university-affiliated ART and oncology centers. Patients: 20 cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue, with the aim to conceive.
- Trial name
- NCT02659592
- Testing
- transplantation of ovarian tissue
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
in Vitro Fertilization
The Role of DNA Damage of Granulosa Cell on Oocyte Quality and in Vitro Fertilization Outcome
Deoxyribonucleic acid (DNA) damage of granulosa cells obtained during oocyte retrieval will be evaluated by comet assay in unexplained infertile patients undergoing in vitro fertilization (IVF) treatment.
- Trial name
- NCT03345030
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Oxidative Stress
Association Between Oxidative Parameters in Fertilization Medium of Cumulus Oocyte Complex and Outcome in IVF
Medium of cumulus-oocyte complex will be assessed for oxidative status.
- Trial name
- NCT03382002
- Testing
- TCL
- Where
- Israel
- Volunteers
- 322 people
- Sponsor
- Carmel Medical Center
Infertility
Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol
The purpose of this study is to determine if pretreatment with Estrogen can assist in the planning and programming of In Vitro Fertilization treatments.
- Trial name
- NCT01419353
- Testing
- estradiol valerate
- Where
- Israel
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Infertility, Ovarian Hyperstimulation Syndrome
Short Versus Long Protocol for IVF and IVF+ICSI
Purpose: Comparing a GnRH agonist and an antagonist protocol for IVF/ICSI with regard to 1. frequency of ovarian hyperstimulation syndrome (OHSS) (1. outcome measure) 2. quality of life (2. outcome measure) 3. live birth rate (2.
- Conditions
- Infertility, Ovarian Hyperstimulation Syndrome, Quality of Life, Live Birth
- Trial name
- KvL (NCT00756028)
- Testing
- Patients receiving short protocol IVF/ICSI-treatment., Long protocol
- Where
- 2 sites in Denmark
- Volunteers
- 1,099 people
- Sponsor
- Peter Hornnes, MD, DMSc
Pregnancy Related, Infertility, Female
Innovation for Small-scale Experiments: ReceptIVFity Test
The ReceptIVFity acts as a timing-tool for prediction of optimal pregnancy chances and provides insight into the patient's current (two months after sampling) success rate of an IVF/IVF-ICSI treatment.
- Conditions
- Pregnancy Related, Infertility, Female, Subfertility, Female
- Trial name
- ReceptIVFity (NCT06051201)
- Testing
- ReceptIVFity test (vaginal microbiome swab)
- Where
- Netherlands
- Volunteers
- 683 people
- Sponsor
- Erasmus Medical Center
Polycystic Ovary Syndrome
Metformin Treatment Before in Vitro Fertilization (IVF) in Women With Ultrasound Evidence of Polycystic Ovaries
The aim of study was to investigate whether pre-treatment with metformin before and during IVF increases the live birth rate compared to placebo in women with sonographic evidence of polycystic ovaries (PCO), but without any…
- Trial name
- NCT01046032
- Testing
- Metformin
- Where
- 3 sites in United Kingdom
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Infertility
Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI.
- Trial name
- PXN (NCT02051075)
- Testing
- PXN sperm treatment, Sperm activation with PXN and oocyte activation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Infertility
Safety and Efficacy of Freezing and Thawing of Human Eggs in Assisted Reproductive Technology
The purpose of this study is to determine the effectiveness of the ViaCell's product media for freezing and thawing human eggs for future use in assisted reproductive technology.
- Trial name
- NCT00451009
- Testing
- Viacell's product Media Kits
- Where
- 4 sites in United States
- Sponsor
- ViaCell
Long QT Syndrome, Brugada Syndrome
Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A
In patients expressing the SCN5A-E1784K mutation (Glu1784Lys), cardiovascular risk is difficult to define as the stratification of these patients is challenging.
- Conditions
- Long QT Syndrome, Brugada Syndrome, Cardiac Conduction System Disease, Arrhythmias, Cardiac
- Trial name
- RISKOVER (NCT05274646)
- Where
- Reunion
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
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