Clinical trials: Ivf
Infertility, IVF
Immediate Versus Postponed Single Blastocyst Transfer in mNC-FET
The purpose of this randomized controlled trial is to investigate if immediate single blastocyst transfer (in the first menstrual cycle following oocyte retrieval) is non-inferior to standard postponed single blastocyst transfer…
- Trial name
- NCT04748874
- Testing
- Immediate mNC-FET
- Where
- Denmark
- Volunteers
- 464 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infertility, Infertility (IVF Patients)
Language Matters: Exploring the Impact of Language Concordance on Fertility Treatment Progression
Currently, patients presenting to the Fertility and Reproductive Medicine Center meet with an English-speaking provider and communicate through an interpreter, as none of the physicians speak Spanish.
- Conditions
- Infertility, Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Ovulation Ind
- Trial name
- ImpaLa (NCT06636838)
- Testing
- Spanish-Speaking Provider
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
IVF
Confounding Factors of Chronic Endometritis in Women With Reproductive Failure
The aim of the study is to investigate the confounding factors of chronic endometritis and therapeutic benefits of antibodies targeting plasma cells in women with reproductive failure.
- Trial name
- NCT05613049
- Where
- Hong Kong
- Volunteers
- 720 people
- Sponsor
- Chinese University of Hong Kong
Reproductive Issues, Subfertility
A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis
During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate.
- Conditions
- Reproductive Issues, Subfertility, IVF
- Trial name
- NCT05896709
- Testing
- MK-RS
- Where
- Hong Kong
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
IVF
Pivotal Observational CHLOE Study
This pivotal study is an observational, prospective assessment, multi-center, databank based, clinical study aimed to evaluate the performance of CHLOE™ algorithm in prediction of blastocyst formation.
- Trial name
- NCT06111365
- Testing
- CHLOE
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Fairtility
Infertile Women Undergoing IVF or ICSI
Benefit of Ethanol Sclerotherapy of Endometriomas Before Ovarian Stimulation on Pregnancy Rates in IVF/ICSI
Evaluation of progressive pregnancy rates (with an embryo with cardiac activity at 12 weeks), on a first attempt at IVF/ICSI (fresh and frozen embryo transfers) following the discovery of one or two endometrioma(s) of 30 to 80…
- Trial name
- SCLERENDO (NCT06878053)
- Testing
- ethanol sclerotherapy
- Volunteers
- 174 people
- Sponsor
- Poissy-Saint Germain Hospital
Oligospermia, DNA Damage
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
In patients with oligospermia in the ejaculate or previous ICSI failures if it concurs with high DNA fragmentation, it has been hypothesized that the use of sperm obtained from the testicle would improve the clinical results…
- Conditions
- Oligospermia, DNA Damage, IVF, ICSI
- Trial name
- NCT04795440
- Testing
- Testicular biopsy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Fundación IVI
Frozen Embryo Transfer (FET), Assisted Reproductive Techniques
Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology
The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments.
- Conditions
- Frozen Embryo Transfer (FET), Assisted Reproductive Techniques, In Vitro Fertilization (IVF), Cryopreservation of Embryos
- Trial name
- DW-FET-RCT (NCT06741748)
- Testing
- Direct Warming Method, Conventional Multi-step Thawing Method
- Where
- 3 sites in Hong Kong, United Kingdom
- Volunteers
- 578 people
- Sponsor
- Chinese University of Hong Kong
Ivf, Frozen Embryo Transfer (FET)
Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus Progesterone
Background: The capability to transfer frozen embryos reduces embryo loss following in vitro fertilization (IVF) and results in higher pregnancy rates compared to a single IVF cycle.
- Trial name
- NCT06870266
- Testing
- Nafarelin nasal spray, Utrogestan®
- Volunteers
- 150 people
- Sponsor
- Shaare Zedek Medical Center
Clinical Pregnancy Rate, Ovulation Induction
Follicular Long GnRH Agonist Versus Antagonist Protocol in PCOS Women Undergoing in Vitro Fertilization
Pituitary down regulation is widely used during in vitro fertilization (IVF) procedures. It can suppress the spontaneous luteinizing hormone (LH) surge, and can also make follicles growth evenly.
- Conditions
- Clinical Pregnancy Rate, Ovulation Induction, IVF
- Trial name
- NCT02496754
- Testing
- GnRH-a, GnRH-anta
- Where
- China
- Volunteers
- 1,266 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Infertility (IVF Patients)
CircularRNA-microRNA-mRNA Regulatory Axis in IVF
1. Investigate the expression levels of circ-0033392, miR-375, miR-1305, JAK2, and PTEN in follicular fluids of females candidate for IVF. 2.
- Trial name
- IVF (NCT06792266)
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Assiut University
Embryo Development, Blastocyst IVF
Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate
This prospective study aims to compare the effects of light and heavy paraffin oil in embryo culture during in vitro fertilization (IVF).
- Conditions
- Embryo Development, Blastocyst IVF, Pregnancy Rates, IVF
- Trial name
- NCT06838923
- Testing
- Light Paraffin Oil, Heavy Paraffin Oil
- Where
- Vietnam
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Infertility, Female, Premature Ovarian Failure
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected.
- Conditions
- Infertility, Female, Premature Ovarian Failure, IVF
- Trial name
- NCT04390308
- Testing
- Ovarian puncture, Hormonal blood Test, Transvaginal ultrasound
- Where
- United Arab Emirates
- Volunteers
- 70 people
- Sponsor
- ART Fertility Clinics LLC
Observational Study of IVF Patients
Fertility: Infection and Inflammation
The investigators explore whether inflammatory factors and infections in collected samples are altered in fertility issues and if they can predict pregnancy outcomes.
- Trial name
- InFert (NCT06826820)
- Where
- Austria
- Volunteers
- 800 people
- Sponsor
- Medical University of Graz
Poor Responders in IVF
Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.
- Trial name
- NCT03560583
- Testing
- Metoclopramide
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
In Vitro Fertilization (IVF)
Assessment of Some Metabolic and Hematological Markers in Women Exposed to in Vitro Fertilization
Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases).
- Trial name
- NCT06812663
- Volunteers
- 115 people
- Sponsor
- Assiut University
Infertility (IVF Patients), Ovarian Aging
Egg Quality Assessment
The goal of this observational study is to learn about egg physiology in humans. The main question it aims to answer is if there is an association between egg physiology and egg quality.
- Conditions
- Infertility (IVF Patients), Ovarian Aging, IVF
- Trial name
- NCT06609421
- Testing
- Informative Appointment
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Ovom Care GmbH
Pregnancy Rate IVF, Blastocyst IVF
Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?
This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA).
- Trial name
- NCT06795984
- Testing
- Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Calla IVF Center
Infertility (IVF Patients), Infertile Females or Females with Ovarian Insufficiency
Evaluation of Pregnancy Outcome with Usage of Drug-free In-vitro Activation of Follicles Ovary
This study is the pilot study to evaluate the effect of Drug-free in vitro activation to improve the outcomes of IVF in poor responder women
- Trial name
- NCT06769789
- Testing
- Drug free invitro activation Ovary
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Malihe Mahmoudinia
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
ReceptIVFity & Immunology in ART
The goal of this clinical non-invasive observational pilot study is to improve the prediction of pregnancy success after In Vitro Fertilisation (IVF)/IVF -Intracytoplasmic Sperm Injection (ICSI) treatment by examining the vaginal…
- Trial name
- R-IMinART (NCT06709976)
- Testing
- Vaginal microbiome swab, Menstrual Blood Collection via Menstrual Cup
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center