Clinical trials: Ivf, active
Infertility (IVF Patients), Infertile Females or Females with Ovarian Insufficiency
Evaluation of Pregnancy Outcome with Usage of Drug-free In-vitro Activation of Follicles Ovary
This study is the pilot study to evaluate the effect of Drug-free in vitro activation to improve the outcomes of IVF in poor responder women
- Trial name
- NCT06769789
- Testing
- Drug free invitro activation Ovary
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Malihe Mahmoudinia
IVF
Progesterone Levels and Frozen Embryo Transfer Outcomes
Frozen embryo transfers (FET) now represent the majority of all embryo transfer cycles, and upwards of 60% live births in United States are now attributable to frozen embryo transfers (1).
- Trial name
- PLATO (NCT07252622)
- Testing
- Blood draw
- Volunteers
- 659 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology
Impact of Day 2 Versus Day 3 Fresh Embryo Transfer on Live Birth Rate in Poor-Prognosis Patients
This study aimed to compare the efficacy (live birth rate) of fresh embryo transfer on Day 2 versus Day 3 in POSEIDON Group 4 patients, and to determine the optimal timing of embryo transfer for this population.
- Conditions
- POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology, Female Infertility Due to Diminished Ovarian Reserve
- Trial name
- NCT07533695
- Testing
- Day 2 Fresh Embryo Transfer
- Volunteers
- 470 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Short-coupled Ventricular Fibrillation, Idiopathic Ventricular Fibrillation
Role of Anti-TREK-1 Autoantibodies in SCVF
Short-coupled ventricular fibrillation (SCVF) is a lethal, primary electrical disorder and an important cause of unexplained cardiac arrest.1 Recent work from our group suggests that a substantial proportion of SCVF cases is…
- Trial name
- TRACK-VF (NCT06943365)
- Testing
- Repeat plasma screening for the presence or absence of anti-TREK-1 autoantibodies, DPP6 risk haplotype
- Where
- 5 sites in Canada, Netherlands
- Volunteers
- 300 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Infertility Assisted Reproductive Technology, Infertility (IVF Patients)
Blastocyst AI Assisted Morphokinetics in ART
The goal of this observational study is to learn if embryo characteristics obtained via the recording of real-time embryo activity via 30-seconds video capture (e.g.: Embryo Morphokinetics) can correlate with known embryo outcome…
- Trial name
- AIM (NCT07611448)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Viable Biosciences
Single Embryo Transfer, Fertilization in Vitro
Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).
Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure.
- Trial name
- TRABLAN (NCT06177613)
- Testing
- Blank culture transfer
- Where
- 7 sites in France, Reunion
- Volunteers
- 1,154 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Advanced Age, Recurrent Pregnancy Loss(RPL)
Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer
Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss.
- Conditions
- Advanced Age, Recurrent Pregnancy Loss(RPL), Infertility (IVF Patients), Sequence Analysis
- Trial name
- NICSAI-SBT-RCT (NCT07461077)
- Testing
- NICS-AI, Morphology group
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Oocyte Maturation, Infertility
OSC Co-culture for Rescue IVM of Human GV Oocytes
This single-center randomized sibling-oocyte controlled trial evaluates whether co-culture with induced pluripotent stem cell (iPSC)-derived ovarian support cells (OSCs) improves rescue in vitro maturation (r-IVM) outcomes of…
- Trial name
- OSC-rIVM (NCT07559357)
- Testing
- Conventional rescue in vitro maturation, Rescue in vitro maturation with iPSC-derived ovarian support cell co-culture
- Where
- Vietnam
- Volunteers
- 102 people
- Sponsor
- Hung Vuong Hospital
Infertility, In Vitro Maturation of Oocytes
Aspire In Vitro Maturation Study
A study to assess the Capacitation - in-vitro maturation (CAPA-IVM) system as an option for patients with a good ovarian reserve to achieve pregnancy.
- Conditions
- Infertility, In Vitro Maturation of Oocytes, Assisted Reproduction Technologies
- Trial name
- AIM (NCT07789730)
- Testing
- CAPA-IVM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Inception Fertility Research Institute, LLC
Endometriosis, Omics
SH-SDU Shandong Endometriosis Reproductive Cohort
Endometriosis (EMs) is a chronic, estrogen-dependent, multi-systemic disease that affects approximately 190 million women worldwide.
- Conditions
- Endometriosis, Omics, Assisted Reproductive Technology
- Trial name
- NCT07558629
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Shandong University
Infertility
International Pilot Study for Dual Non-invasive Assesment of Embryo Development
Choosing the best embryo is one of the major challenges for achieving success in in vitro fertilization (IVF). Traditionally, embryo evaluation has been based on morphological quality (how the embryo looks like) and chromosomal…
- Trial name
- PANDORA (NCT06524648)
- Testing
- niPGT-A
- Where
- 8 sites in Austria, Spain and 1 more
- Volunteers
- 200 people
- Sponsor
- Igenomix
Children, ART
Enhancing Management Algorithms for Children Conceived Via Assisted Reproductive Technologies
Research Methods and Ethical Issues 1. Main Scientific Questions and Hypotheses of the Project The primary objective of this project is to investigate the impact of advanced ART methods on the health status of children.
- Conditions
- Children, ART, Anthropometric Characteristics, Somatic Health Status
- Trial name
- NCT07278960
- Testing
- Inhibin B, Anti-Müllerian Hormone (AMH)
- Where
- Kazakhstan
- Volunteers
- 300 people
- Sponsor
- Kazakhstan's Medical University "KSPH"
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility (IVF Patients), ICSI
Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical Potential
Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to develop an artificial intelligence platform for the analysis of sperm samples and prediction of their clinical…
- Conditions
- Infertility (IVF Patients), ICSI, IVF Outcomes, Male Infertility
- Trial name
- Spermy01 (NCT07456397)
- Testing
- Swim-up, Density gradient centrifugation, HyperSperm
- Where
- 5 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Fecundis Lab SL
Implantation, Embryo
Longitudinal Clinical Observation of a Digital Twin Model for Blastocyst Evaluation in IVF Clinics
This study aims to develop and validate a non-image, multimodal digital twin model of the human blastocyst using fully de-identified clinical, laboratory, molecular, biochemical, and long-term follow-up data obtained during…
- Trial name
- IVFDT (NCT07305480)
- Testing
- Digital Twin Computational Modeling
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Ukraine Association of Biobank
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
IVF\ICSI Outcome in Women With Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) occurs in 5% to 10% of all women of reproductive age and 50% of women who present with sub-fertility due to anovulatory infertility .
- Trial name
- NCT05756023
- Testing
- the pregnancy rate at IVF / ICSI cycles
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Egymedicalpedia
Infertility, Female, Infertility, Male
Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.
- Conditions
- Infertility, Female, Infertility, Male, Infertility, IVF
- Trial name
- NCT06419127
- Testing
- Timelapse incubation and PGT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Gattaca Genomics
IVF, Infertility
What To-be-discard Biomaterials From ART Cycles Can Tell us About the Treatment Cycle Outcome?
Various to-be-discard material from IVF treatment cycle will be collect and examined, aiming to identify potential reasons of successful outcome or cycle failure.
- Trial name
- NCT06021340
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Polycystic Ovary Syndrome
IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer
A protocol was developed to improve pregnancy results after IVM compared to results from studies in the literature. Differences from most published protocols include the use of the Steiner-Tan needle to optimize oocyte…
- Trial name
- IVMprt (NCT04149496)
- Testing
- in vitro maturation of oocytes
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Bruce Rose, MD
Health Related
Newborns From Patients Treated With ART (Assisted Reproductive Technology)
The Prospective Cohort Study for Newborns from patients treated with ART was set up to investigate the short- and long-term health consequences in Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University…
- Trial name
- NCT03993158
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University