Clinical trials: JIA
Juvenile Idiopathic Arthritis, Rheumatic Diseases
Low-energy Laser Applications in Patients With Juvenile Idiopathic Arthritis
This study endeavored to evaluate the auxiliary effect of low-energy laser therapy (LLT) on pain, muscle performance, fatigue, and functional ability in children with juvenile idiopathic arthritis (JIA).
- Conditions
- Juvenile Idiopathic Arthritis, Rheumatic Diseases, Chronic Knee Pain, Fatigue
- Trial name
- NCT05031104
- Testing
- Physical Exercise, Physical Exercise plus Low-energy Laser Therapy
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Cairo University
Psoriatic Arthritis, Juvenile, Polyarticular Juvenile Idiopathic Arthritis
Korea Xeljanz Post-marketing Surveillance for Juvenile Idiopathic Arthritis
This study is to assess the safety and effectiveness of Xeljanz in Juvenile Idiopathic Arthritis (JIA) patients in routine clinical practice in Korea. JIA patients experience persistent joint pain, swelling and stiffness.
- Trial name
- KRXeljanzJIA (NCT05754710)
- Testing
- Xeljanz
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Pfizer
Juvenile Psoriatic Arthritis, Enthesitis-related Arthritis
Secukinumab Safety and Efficacy in Juvenile Psoriatic Arthritis (JPsA) and Enthesitis-related Arthritis (ERA)
This was a double-blind, placebo-controlled, event-driven randomized withdrawal study to investigate the efficacy and safety of secukinumab treatment in the Juvenile Idiopathic Arthritis (JIA) categories of Juvenile Psoriatic…
- Trial name
- NCT03031782
- Testing
- secukinumab
- Where
- 31 sites in United States, Belgium and 8 more
- Volunteers
- 86 people
- Sponsor
- Novartis Pharmaceuticals
Systemic Juvenile Idiopathic Arthritis
An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and Without Fever.
This open-label extension study will permit patients with Systemic Juvenile Idiopathic Arthritis (SJIA) who previously were responsive to treatment with canakinumab and canakinumab treatment-naïve patients with active SJIA with…
- Trial name
- β-SPECIFIC 3 (NCT00891046)
- Testing
- Canakinumab
- Where
- 73 sites in United States, Argentina and 19 more
- Volunteers
- 270 people
- Sponsor
- Novartis Pharmaceuticals
Juvenile Idiopathic Arthritis
An Extension Long-Term Study of RoActemra/Actemra (Tocilizumab) in Patients With Polyarticular Juvenile Idiopathic Arthritis Who Completed The WA19977 Study
This long-term, open-label extension study will evaluate the safety of RoActemra/Actemra (tocilizumab) in patients with polyarticular-course juvenile idiopathic arthritis who completed the WA19977 core study.
- Trial name
- NCT01727986
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 4 sites in Brazil
- Volunteers
- 11 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis
Use of Thermal and 3D Imaging to Quantify Arthritis
One of the biggest challenges in caring for patients with Rheumatoid Arthritis (RA) and Juvenile Rheumatoid Arthritis (JRA) is quantifying the degree of disease activity in any given joint.
- Trial name
- NCT01044823
- Testing
- 3D and thermal imaging
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- University of Pittsburgh
Uveitis
Childhood Uveitis Initial Management and One-year Outcomes
The investigators wish to establish a robust estimate of the incidence of inflammation inside the eye (uveitis) in children age 0-16 years in the UK, which hospitals children present to, where they are referred to, which…
- Trial name
- NCT02490254
- Testing
- Surveillance card
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Juvenile Idiopathic Arthritis
A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS)
The purpose of this study is to evaluate the efficacy and safety of golimumab (CNTO 148) in patients who have active juvenile idiopathic arthritis (JIA) and at least 5 joints with active arthritis that have poor response to…
- Trial name
- NCT01230827
- Testing
- CNTO 148 (Golimumab), Methotrexate
- Where
- 35 sites in United States, Austria and 10 more
- Volunteers
- 173 people
- Sponsor
- Janssen Research & Development, LLC
Upper Extremity Dysfunction, Gait, Unsteady
The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected
It has been shown that movements of the upper extremity during walking are associated with lower extremity mobility. For example, when walking at a slow pace, the swing frequency of the arms is 2: 1 compared to the legs, while…
- Conditions
- Upper Extremity Dysfunction, Gait, Unsteady, Juvenile Idiopathic Arthritis, Balance
- Trial name
- NCT04671524
- Testing
- Exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Uveitis, Juvenile Arthritis
Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis
The investigators propose to study the efficacy of adalimumab versus placebo (double-blind randomization on inclusion into 2 equal groups) on reduction of ocular inflammation quantified by laser flare photometry after two months…
- Trial name
- ADJUVITE (NCT01385826)
- Testing
- Anti-tumor necrosis factor alpha monoclonal antibody
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Juvenile Idiopathic Arthritis, Tenosynovitis
Tenosynovitis in Polyarticular and Oligoarticular Juvenile Idiopathic Arthritis
Juvenile Idiopathic Arthritis (JIA) is a chronic condition that causes joint inflammation in children. In some cases, the inflammation also affects the protective sheath surrounding the tendons, a condition known as…
- Conditions
- Juvenile Idiopathic Arthritis, Tenosynovitis, Polyarticular Juvenile Idiopathic Arthritis, Oligoarticular Juvenile Idiopathic Arthritis
- Trial name
- NCT07553910
- Volunteers
- 106 people
- Sponsor
- Assiut University
Juvenile Idiopathic Arthritis
Determining Predictors of Safe Discontinuation of Anti-TNF Treatment in JIA
Polyarticular juvenile idiopathic arthritis (Poly JIA) is a form of juvenile arthritis, which is a chronic disease affecting approximately 250,000 people younger than 16 years of age.
- Trial name
- NCT00792233
- Testing
- Withdrawal of anti-TNF therapy
- Where
- 16 sites in United States
- Volunteers
- 137 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Arthritis, Juvenile Idiopathic, Enthesitis-Related Arthritis, Juvenile
Juvenile Arthritis Quantitative Imaging
This observational study aims to develop and validate quantitative magnetic resonance imaging biomarkers as measures of disease activity in juvenile idiopathic arthritis (JIA).
- Trial name
- JAQI (NCT02684695)
- Testing
- MRI scan (adolescent spine protocol), MRI scan (whole body protocol)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Systemic Juvenile Idiopathic Arthritis
Study to Evaluate the Safety and Tolerability of Two Doses of Rilonacept in Pediatric Subjects With Active Systemic Juvenile Idiopathic Arthritis (SJIA)
This study is a pilot, ascending dose, multi-center, randomized, double blind, placebo controlled, pediatric study conducted in three phases.
- Trial name
- NCT01803321
- Testing
- rilonacept (IL-1 Trap)
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Regeneron Pharmaceuticals
Juvenile Idiopathic Arthritis
The iPeer2Peer Program for Adolescents With Juvenile Idiopathic Arthritis
The iPeer2Peer program matches teens with arthritis to an older mentor who has learned to manage their arthritis well and can support them emotionally and socially.
- Trial name
- iPeer2Peer (NCT03116763)
- Testing
- iPeer2Peer Mentorship, Active Comparator: Control Group
- Where
- 6 sites in Canada
- Volunteers
- 164 people
- Sponsor
- The Hospital for Sick Children
Rheumatoid Arthritis, Idiopathic Juvenile Arthritis
Pharmacogenetic Studies on Anti-IL-6 Receptor Monoclonal Antibodies on the Treatment of Rheumatic Diseases
Tocilizumab and Sarilumab are first-line biological disease-modifying anti-rheumatic drug (bDMARD) which inhibits Interleukin 6 (IL-6) pathway through blockade of its receptor on the treatment of Rheumatoid Arthritis and other…
- Conditions
- Rheumatoid Arthritis, Idiopathic Juvenile Arthritis, Giant Cell Arteritis, Still Disease
- Trial name
- NCT05045001
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Systemic Juvenile Idiopathic Arthritis (sJIA)
Role of Interleukin 18 (IL-18) and Interleukin 18 Binding Protein (IL-18BP) in the Diagnostic Work-up of Systemic Juvenile Idiopathic Arthritis and Autoinflammatory Diseases: Possible Biomarkers in the Differential Diagnosis of Other Febrile Diseases
Literature data suggest that elevated blood values of IL-18 and IL-18 Binding Protein and alterations in their ratio may be significantly correlated with various autoinflammatory diseases, such as systemic juvenile idiopathic…
- Trial name
- NCT06718049
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Juvenile Idiopathic Arthritis
Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis
The objective of this study is to compare in very early polyarticular juvenile idiopathic arthritis (JIA) the efficacy, safety, and cost-benefit-ratio of three treatment strategies: biologic combination, combination of…
- Trial name
- ACUTE-JIA (NCT01015547)
- Testing
- Infliximab plus methotrexate, Combination of DMARDs, Methotrexate alone
- Where
- 6 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Spinal Cord Injuries, Spina Bifida
Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities
Participation in community-based activities is essential to the health and well-being of youth with physical disabilities; yet, it is extremely restricted.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT05784285
- Testing
- Engagement in a 8-week community-based activity program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
Inflammatory Response
NEMOS in Normal Volunteer and JIA Study
This will be a two-stage study to test whether t-VNS using the NEMOS device can activate the CAP and reduce markers of systemic inflammation. Stage A (healthy volunteers) stage B (patients with Juvenile Idiopathic Arthritis).
- Trial name
- NCT01924780
- Testing
- Stimulation 10 minutes, NEMOS transvagal stimulation 60 minutes
- Where
- 2 sites in Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Karin Palmblad