Clinical trials: Jaundice
Jaundice, Periampullary Cancer
Preoperative Biliary Drainage With Metal Versus Plastic Stents in Periampullary Cancer
Currently, routine preoperative biliary drainage (PBD) was not recommended. However, PBD is still necessary in case of patients with cholangitis or very high level of bilirubin or patients who are expected to receive delayed…
- Trial name
- NCT02787512
- Testing
- Stent
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Neonatal Hyperbilirubinemia
MRA and ABR as Early Predictors of Bilirubin-Induced Neurologic Dysfunction in Full-term Jaundiced Neonates
The aim of the research was to define the role of MRS and ABR as early predictors of bilirubin-induced neurologic dysfunction (BIND) in full-term neonates who required intervention (phototherapy or exchange transfusion).
- Trial name
- NCT06018012
- Testing
- MRS and ABR
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Tanta University
Neonatal Jaundice
Clinical Validation of the Screening Tool Picterus JP Using Different Smartphones
The overall aim of this study is to verify the quality of our internal developed camera validation systems and allow the use of Picterus JP on all smartphones.
- Trial name
- allphones (NCT05955144)
- Testing
- Picterus JP
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Picterus AS
Calcular Obstructive Jaundice
Primary Precutting Versus Conventional Over-the-Wire Sphinchterotomy For Managment Of Large Common Bile Duct Stones
During the last decades, endoscopic retrograde cholangiopancreatography (ERCP) has become the standard of care for the treatment of many pancreaticobiliary diseases [Canena et al., 2014].
- Trial name
- NCT06106724
- Testing
- sphincterotomy, precutting of the papilla by knife needle
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Neonatal Jaundice, Hyperbilirubinemia
Compassionate Use of Stanate (TM) [Stannsoporfin]
The purpose of this protocol is to make Stanate (TM) [stannsoporfin, tin-mesoporphyrin] available to infants who meet the following criteria: 1.
- Trial name
- NCT00076960
- Testing
- Stanate (TM) [stannsoporfin, tin-mesoporphyrin]
- Where
- United States
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Hyperbilirubinemia
Transcutaneous Bilirubinometry in Healthy Term and Near-Term Neonates
Objectives: Bilirubin measured by transcutaneous bilirubinometry (TcB) is a reasonably accurate estimate of serum total bilirubin (STB).
- Trial name
- NCT00653874
- Testing
- BiliChek (jaundice assessment), Transcutaneous bilirubinometry (TcB), Clinical asessment of bilirubin (CaB)
- Where
- India
- Volunteers
- 617 people
- Sponsor
- All India Institute of Medical Sciences
Neonatal Jaundice, Neonatal Hyperbilirubinemia
Evaluation of Bilirubin Estimates in Newborns From Smartphone Digital Images in a Population in Botswana
This project aims to test a novel smartphone application, Picterus, which provides a cheaper, patient-friendly, and more readily means of neonatal jaundice detection.
- Trial name
- BILIAPPBOT (NCT06399146)
- Testing
- Picterus App
- Where
- Botswana
- Volunteers
- 150 people
- Sponsor
- Hillerod Hospital, Denmark
Hepatic and Post Hepatic Jaundice
Clinical Study Evaluating Efficacy, Safety and Molecular Mechanism of N-acetylcysteine Supplementation in Patients With Hepatic and Post Hepatic Jaundice
Investigating the efficacy, safety, and molecular mechanism of N-acetylcysteine supplementation in improving elevated direct bilirubin level and liver function tests in patients with hepatic and post-hepatic jaundice.
- Trial name
- NCT06236165
- Testing
- N-acetylcysteine
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Neonatal Jaundice
Comparison of the Efficacy of Phototherapy Using Blue LED's With Wavelength 478 vs. 459 nm.
Treatment of neonatal jaundice is phototherapy with blue light at wavelength about 460 nm and irradiance > 30 uw/cm2/nm. Though, recent in vitro models have suggested that a wavelength of 478 nm should be optimal in reducing…
- Trial name
- NCT03183986
- Testing
- Phototherapy
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Neonatal Jaundice From Other Specified Causes, ABO Incompatibility
The Role of Breastmilk and Serum Exosomes in Neonatal Jaundice Due to ABO Incompatibility
Neonatal jaundice is a major global health issue that can lead to serious complications and even death if not promptly treated. ABO incompatibility is a common cause of pathological neonatal jaundice, but there are currently no…
- Conditions
- Neonatal Jaundice From Other Specified Causes, ABO Incompatibility, ABO Hemolytic Disease
- Trial name
- NCT06502847
- Testing
- Exosome profile study
- Where
- Turkey (Türkiye)
- Volunteers
- 338 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Jaundice, Neonatal, Hyperbilirubinemia, Neonatal
Identification of Jaundice in Newborns Using Smartphones
Neonatal jaundice is a common and most often harmless condition. However, when unrecognized it can be fatal or cause serious brain injury. Three quarters of these deaths are estimated to occur in the poorest regions of the world.
- Trial name
- NCT04182555
- Testing
- Bilirubin estimates from Smartphone Application, Bilirubin concentration measured in standard blood samples, Bilirubin estimates from standard transcutaneous device
- Where
- 2 sites in Norway
- Volunteers
- 220 people
- Sponsor
- St. Olavs Hospital
Jaundice, Neonatal
Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates
The primary objective of this study is to determine the safety and efficacy of filtered sunlight phototherapy. Sunlight will be filtered by flexible (window-tinting) film.
- Trial name
- NCT01434810
- Testing
- Filtered-sunlight phototherapy, Conventional phototherapy
- Where
- Nigeria
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Jaundice, Neonatal, Phototherapy
Effectiveness, Safety and Perceptions With the Use of One LED Blanket Device in the Ambulatory Treatment of Jaundice
Objective: to evaluate the effectiveness, safety and level of satisfaction of parents and healthcare team with one innovative device for phototherapy to which a LED light mesh has been incorporated(a blanket), comparing it with…
- Trial name
- LEDlightT2 (NCT03569254)
- Testing
- Neomedlight Phototherapy Blanket, Ohmeda-Fiber Optic Phototherapy Blanket
- Where
- Colombia
- Volunteers
- 64 people
- Sponsor
- Nathalie Charpak
Nutritional and Metabolic Diseases
Efficacy and Safety of Stannsoporfin in Neonates
This is a multi-center, randomized, sham injection-controlled (placebo) masked trial of a single intramuscular injection of Stannsoporfin compared to "sham" (placebo) in healthy term and near-term newborns admitted to the…
- Trial name
- NCT02685137
- Testing
- stannsoporfin
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Calcular Obstructive Jaundice
*Effect of Prophylactic CBD Stenting Versus Non Stenting on Recurrence of CBD Stones in Patients Awaiting Cholecystectomy*
Primary objective: Compare recurrence rates of CBD stones in stented versus non-stented patients. Secondary objectives: Identify predictors of stone recurrence. Assess the incidence and risk factors for post-ERCP complications.
- Trial name
- NCT07084493
- Testing
- CBD stent either a 7-Fr and 7 cm or a 10-Fr and 7-cm OR double-pigtail stent, biliary stent
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Assiut University
Obstructive Jaundice, Pancreatic Cancer
Comparison of Metal and Plastic Stents for Preoperative Biliary Decompression
Covered self expandable metal stents (CSEMS) are three times larger in diameter than 10 Fr plastic stents. When compared to plastic stents, randomized trials have shown longer patency and fewer stent-related complications for…
- Trial name
- NCT01191814
- Testing
- Metal stent, Plastic stent
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- AdventHealth
Neonatal Jaundice
NeoSCB App for Screening Jaundice in Newborns
About 60% of babies born after 36 weeks of pregnancy have jaundice during the first two weeks of life. Due to the accumulation of bilirubin in the bloodstream, jaundiced babies appear yellow, which allows healthcare professionals…
- Trial name
- neoSCB (NCT06963450)
- Testing
- Taking photos of a baby's eye
- Where
- United Kingdom
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University College, London
Neonatal Jaundice, Hyperbilirubinemia
Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns
In South Africa, healthy term newborns are usually discharged early (<72 hours after delivery). Many studies have shown that hospital readmission rates have increased with this practice, and jaundice or hyperbilirubinemia is the…
- Trial name
- NCT02613676
- Testing
- Transcutaneous bilirubin screening, Standard care (Visual inspection)
- Where
- South Africa
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Jaundice, Neonatal
Comparison Of Fenofibrate Vs Phenobarbitone As Adjunct To Phototherapy In Reducing Total Serum Bilirubin In Indirect Hyperbilirubinemia In Neonates
This is a prospective, randomized, open-label controlled trial comparing fenofibrate (10 mg/kg) and phenobarbitone (3 mg/kg) as adjuncts to conventional phototherapy in neonates with unconjugated hyperbilirubinemia.
- Trial name
- NCT07774741
- Testing
- Fenofibrate + Phototherapy, Phenobarbitone + Phototherapy
- Volunteers
- 70 people
- Sponsor
- Rubab Fatima
Pancreaticobiliary Cancers, Jaundice
Endoscopic Ultrasound Versus Endoscopic Retrograde Cholangiopancreatography (ERCP) Tissue Sampling for the Diagnosis of Suspected Pancreatico-Biliary Cancer
The two most commonly used methods to biopsy suspected pancreaticobiliary masses are (1) endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) and (2) cytology brush biopsies obtained during endoscopic retrograde…
- Conditions
- Pancreaticobiliary Cancers, Jaundice, Bile Duct Obstruction
- Trial name
- NCT01356030
- Testing
- ERCP, EUS FNA
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- California Pacific Medical Center Research Institute