Clinical trials: Jaw Cancer
Bone Diseases, Metastases
Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer
This study seeks to identify risk factors associated with the development of a jaw condition seen in patients with cancer treated with certain medications.
- Conditions
- Bone Diseases, Metastases, Osteonecrosis, Bisphosphonate-Associated Osteonecrosis of the Jaw
- Trial name
- NCT01325142
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- University of Michigan
Jaw Cysts
Volumetric Analysis of Bone Following Jaw Cysts Enucleation With and Without Alb-PRF
Cyst is the main cause for longstanding swelling in the mandible or the maxilla, its enlargement usually results in resorption and weakening of bone.
- Trial name
- NCT05658900
- Testing
- Enucleation with albumin PRF, Enucleation without albumin PRF
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Hams Hamed Abdelrahman
Periapical Diseases, Radicular Cyst
PRF Membrane and Recovery After Periapical Surgery: A 3D Imaging Study
The goal of this clinical trial is to determine whether a PRF (platelet-rich fibrin) membrane helps improve recovery after periapical surgery in adults.
- Conditions
- Periapical Diseases, Radicular Cyst, Granuloma, Postoperative Complications
- Trial name
- NCT06739200
- Testing
- Platelet-Rich Fibrin (PRF) Membrane
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Mandibular Tumor
Assessment of Accuracy and Aesthetics Following Automated Mandibular Defect Reconstruction Using AI
The Aim of the study is to evaluate Accuracy of automated mandibular defect reconstruction using Artificial intelligence and assessing impact on aesthetic and occlusion outcomes using patient-specific reconstruction plates.
- Trial name
- NCT06945692
- Testing
- patient specific reconstruction plates
- Volunteers
- 4 people
- Sponsor
- Cairo University
Epithelial Odontogenic Tumours
Confrontation Phenotypes and Genotypes of Epithelial Odontogenic Tumors of the Jaws
Systematically compare the phenotype and genotype of epithelial odontogenic tumors in children and adults with a clinical, radiographic, pathologic and molecular level.
- Trial name
- TEIOS (NCT02167581)
- Where
- France
- Volunteers
- 319 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neoplastic Syndrome, Non-melanomatous Skin Cancer
Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants
RATIONALE: Studying samples of blood and tissue from patients with basal cell nevus syndrome and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers…
- Trial name
- NCT00433485
- Testing
- sirolimus, comparative genomic hybridization, gene expression analysis
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Apical Periodontitis, Endodontically Treated Teeth
Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery
The purpose of this study is to evaluate the effect of Photobiomodulation (PBM) in postoperative pain after endodontic microsurgery (EMS) in patients from the University of Texas Health Science Center at Houston, School of…
- Conditions
- Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst
- Trial name
- NCT06574152
- Testing
- PBM treatment, EMS
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The University of Texas Health Science Center, Houston
Odontogenic Cyst
Recurrence of Odontogenic Keratocyst
The aim of current cross over clinical trial is to evaluate the effect of topical 5-FU as adjunct therapy in reducing risk of the recurrence of OKCs
- Trial name
- NCT06071806
- Testing
- Topical Application of 5-Fluorouracil
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Cherubism
Natural History of Cherubism Observational Study
To observe the natural history of cherubism.
- Trial name
- NCT01916772
- Testing
- no interventions
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Basal Cell Nevus Syndrome
Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome
This is a single-arm, phase II study to assess the efficacy of combined SMO and PD-1 inhibition with Vismodegib (SMO inhibitor) and Nivolumab (anti-PD-1 antibody) in BCNS patients (target enrollment of 22 patients), with a…
- Trial name
- NCT03767439
- Testing
- Vismodegib, Nivolumab, Ipilimumab
- Sponsor
- Columbia University
Musculoskeletal Complications
Levocarnitine in Treating Patients With Vismodegib-Associated Muscle Spasms
This randomized clinical trial studies levocarnitine in treating patients with vismodegib-associated muscle spasms. Levocarnitine may decrease muscle spasms caused by vismodegib.
- Trial name
- NCT01893892
- Testing
- levocarnitine, questionnaire administration
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Periapical Cyst
Clinical and Radiographic Characteristics and Outcomes of Guided Apicoectomy With Retrograde Mineral Trioxide Aggregate Filling for Periapical Cysts
Patients with periapical cysts associated with premolar teeth often require apical surgery when conventional endodontic treatment cannot resolve the lesion.
- Trial name
- NCT07724964
- Testing
- Guided Apicoectomy With Retrograde Mineral Trioxide Aggregate Filling
- Where
- Vietnam
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
BCCs in Gorlin Syndrome Patients
CODY: A Study Evaluating The Safety And Efficacy Of QTORIN 3.9% Sirolimus Topical Gel For The Prevention Of Basal Cell Carcinomas (BCCs) In Patients With Gorlin Syndrome
A Phase 2b study looks at the safety and efficacy of a treatment that is being investigated for people with certain diseases. This study will be conducted at multiple centers in the United States where participants with Gorlin…
- Trial name
- NCT04893486
- Testing
- PTX-022, Vehicle comparator
- Where
- 16 sites in United States, United Kingdom
- Volunteers
- 73 people
- Sponsor
- Palvella Therapeutics, Inc.
Cancer
Study to Assess Incidence of ONJ in Pts With Bone Mets Starting Zoledronic Acid Treatment
Prospective observational multi central cohort study to assess the incidence of osteo necrosis of jaw in cancer patient with bone metastasis starting Zoledronic acid treatment
- Trial name
- NCT01488851
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
PTCH1 or SMO Activated Solid and Hematologic Tumors
LDE225 for Patients With PTCH1 or SMO Mutated Tumors
The purpose of this signal seeking study is to determine whether treatment with LDE225 demonstrates sufficient efficacy in hedgehog pathway-mutated solid tumors and/or hematologic malignancies to warrant further study
- Trial name
- SIGNATURE (NCT02002689)
- Testing
- LDE225
- Where
- 10 sites in United States
- Volunteers
- 10 people
- Sponsor
- Novartis Pharmaceuticals
Osteoradionecrosis, Radiotherapy
Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy
Osteoradionecrosis (ORN) of the jaw is a serious complication that can occur after radiation therapy for head and neck cancers, including oral cavity cancer (OCC).
- Conditions
- Osteoradionecrosis, Radiotherapy, Risk Factors, Oral Cancer
- Trial name
- AOITC (NCT07836829)
- Volunteers
- 1,000 people
- Sponsor
- AO Innovation Translation Center
Tooth Extraction Status Nos, Cysts Dental
Intravenous Dexamethasone on Postoperative Pain and Complications in Jaw Surgery
This study aims to evaluate the effect of single-dose intravenous dexamethasone on postoperative pain and other complications in compacted tooth and cyst enucleation procedures performed under general anesthesia.
- Conditions
- Tooth Extraction Status Nos, Cysts Dental, General Anesthesia
- Trial name
- DXM-PAIN (NCT06787196)
- Testing
- Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Selcuk University
Neoplastic Syndrome
Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face
RATIONALE: Drugs used in chemotherapy, such as tazarotene, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00489086
- Testing
- tazarotene
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Maxillary Neoplasms
Reconstruction of Maxillary and Midfacial Defects Using Latissimus Dorsi Scapular Free Flaps
Bony reconstruction of the midface with free tissue transfer is complex and challenging due to structural considerations such as the need for orbital support, patency of the nasal cavity, restoration of the palate and alveolus…
- Trial name
- NCT04522700
- Testing
- scapular free flap
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- hassan harby mohamed
Mandibular Neoplasms, Maxillary Neoplasms
Three-Dimensional Printing of Patient-Specific Titanium Plates in Jaw Surgery: A Pilot Study
Medical titanium plates are routinely used in fixing mobilized bone segments in jaw surgeries. Generally these plates are commercialized with standard construction specifications.
- Conditions
- Mandibular Neoplasms, Maxillary Neoplasms, Dentofacial Deformities, Maxillofacial Injuries
- Trial name
- 3DJP16 (NCT03057223)
- Testing
- 3D-printed patient-specific titanium plates
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- The University of Hong Kong