Clinical trials: Joint
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Anti-coagulation Therapy, DVT
Warfarin Adverse Event Reduction For Adults Receiving Genetic Testing at Therapy INitiation (WARFARIN)
The WARFARIN Study is a clinical trial designed to determine if the use of genetic information related to warfarin sensitivity can help create a dose of warfarin that will result in less hospitalizations and deaths related to…
- Conditions
- Anti-coagulation Therapy, DVT, Pulmonary Embolism, Joint Surgery Multiple
- Trial name
- WARFARIN (NCT01305148)
- Testing
- Warfarin GenoSTAT Test
- Where
- 56 sites in United States
- Volunteers
- 3,800 people
- Sponsor
- Iverson Genetic Diagnostics, Inc.
Hip Dysplasia
Can PLIA Reduce Early Post-operative Pain After PAO Surgery?
The goal of this clinical trial is to compare different peri-incisional local infiltrative anesthesia (PLIA) methods in patients ages 13 to 50 undergoing a periacetabular osteotomy (PAO). The main questions to answer here are: 1.
- Trial name
- PILA PAO (NCT06519955)
- Testing
- Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline)
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Michael C Willey
Osteoarthritis of the Knee
Cross-over Study of the Efficacy and Safety of SierraSil Joint Formula 14 in Osteoarthritis of the Knee
Osteoarthritis (OA) affects approximately 10% of people older than 60 years, and compromises the quality of life of more than 21 million North Americans.
- Trial name
- 11SOHS (NCT02156440)
- Testing
- SierraSil Joint Formula 14
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- KGK Science Inc.
Osteoarthritis
Resurfacing Hemiarthoplasty Versus Conventional Stemmed Arthroplasty
Hypothesis: What is the difference in disease specific quality of life between patients who receive a humeral surface replacement hemiarthroplasty verusu a conventioanl stemmed hemiarthroplasty
- Trial name
- NCT00664989
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Ottawa Hospital Research Institute
Shoulder Impingement Syndrome
Impact of Core Stability Training on Pain and Function in Patient With Shoulder Impingement Syndrome Among Manual Operated Hand Workers
Even at the early stage of employment exposure to mechanical factors such as lifting heavy weights, working with hands at or above shoulder level, and pushing or pulling heavy loads are independent risk factors for new-onset…
- Trial name
- NCT07237789
- Testing
- Experimental, Control
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Rheumatoid Arthritis
INCB047986 in Rheumatoid Arthritis
The purpose of this study is to explore the safety, tolerability and efficacy of INCB047986, in subjects with moderate to severe rheumatoid arthritis.
- Trial name
- NCT02151474
- Testing
- INCB047986
- Where
- 9 sites in United States
- Volunteers
- 3 people
- Sponsor
- Incyte Corporation
Keratoconjunctivitis Sicca, Sjogren's Syndrome
Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome
A six-month clinical research trial to evaluate the effectiveness of an investigational medication for the treatment of dry eye syndrome in patients that have been diagnosed with moderate to severe dry eye syndrome, an autoimmune…
- Conditions
- Keratoconjunctivitis Sicca, Sjogren's Syndrome, Lupus Erythematosus, Systemic, Arthritis, Rheumatoid
- Trial name
- NCT00025818
- Testing
- Ophthalmic Emulsion
- Where
- 17 sites in United States
- Volunteers
- 290 people
- Sponsor
- Allergan
Shoulder Impingement, Frozen Shoulder
Relationship of Patient-Specific Functional Scale With Shoulder Functions: A Prospective Study
The aim of the study is to examine the relationship between the Patient- Specific Functional Scale (PSFS) and shoulder functions in the physiotherapy and rehabilitation program applied to patients with shoulder problems.
- Conditions
- Shoulder Impingement, Frozen Shoulder, Humeral Fractures, Rotator Cuff Tears
- Trial name
- NCT04538118
- Testing
- Shoulder disability, Shoulder Range of Motion, Pain Intensity
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Ankara Yildirim Beyazıt University
Osteoarthritis
Vanguard™ Deep Dish Rotating Platform Knee Clinical Evaluation
This study is being conducted on the Vanguard™ Deep Dish Rotating Platform (DD RP) to evaluate the clinical efficacy of the DDRP components.
- Trial name
- NCT00753090
- Testing
- Vanguard™ Deep Dish Rotating Platform Knee, Vanguard™ Cruciate Retaining Knee
- Where
- 4 sites in France, Netherlands and 1 more
- Volunteers
- 326 people
- Sponsor
- Zimmer Biomet
Gonarthrosis
Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy
The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic.
- Trial name
- NCT06914960
- Testing
- 2-point Radiofrequency Ablation, 3-point Radiofrequency Ablation, 5-point Radiofrequency Ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Bengu Turemenogullari
Osteoarthritis Arthritis, Rheumatoid Arthritis
G7 Acetabular System vs. Exceed ABT Acetabular System in THA
Evaluate the safety and effectiveness of patients who received G7 Acetabular system in conjunction with Ceramic on Ceramic articulation and Taperloc Complete Microplasty stem compared to patients who received the Exceed ABT…
- Trial name
- G7 (NCT02340390)
- Testing
- G7, Exceed ABT
- Where
- 3 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Using ROSA for Challenging The TKA Standard of Care
This is a prospective, randomized controlled trial using the cruciate retaining, MC Persona to comparing the conventional TKA to ROSA assisted TKA. Patients will be randomized to one of three study trial arms. 1.
- Trial name
- NCT06267482
- Testing
- ROSA PSA Parapatellar Approach, ROSA PSA Subvastus Approach
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Patellofemoral Pain Syndrome
Relationship Between Constitutional Varus Knee and Patellofemoral Pain
This study aims to research on the relationship between constitutional varus knee and patellofemoral pain. The standardized standing whole-lower-extremity radiographs, the knee lateral view and skyline view of the participants…
- Trial name
- NCT03450824
- Testing
- No intervention
- Where
- China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- 113th Hospital of Chinese People's Liberation Army
Knee Osteoarthritis, Pain
Reiki Effects on Pain, Functional Status and Holistic Well-Being in Patients With Knee Osteoarthritis
This study aimed to examine the effect of Reiki therapy on pain, functional status and holistic well-being in patients with knee osteoarthritis.
- Trial name
- NCT05665959
- Testing
- Reiki
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara Medipol University
Opioid Use, Acute Pain
PENG vs Intra-articular Injection for Hip Arthroscopy
Hip arthroscopy is a popular surgical method that is increasingly being used for both intraarticular and extraarticular hip surgeries.
- Trial name
- PARİAH (NCT04698746)
- Testing
- Pericapsular nerve group block, Intra-articular local anesthetic injection
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Bezmialem Vakif University
Osteoarthritis, Knee, Obesity
Weight Loss Intervention Before Total Knee Replacement
The purpose of this study is to compare the efficacy in a group of patients who must follow the current procedure for treatment of artificial knee, compared with a group of patients who must undergo an 8-week weight loss program…
- Trial name
- NCT01469403
- Testing
- 8 weeks weight loss program, Cambridge.
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Aarhus
Arthritis, Rheumatoid
A Study of CNTO 136 (Sirukumab) Administered Subcutaneously in Japanese Patients With Active Rheumatoid Arthritis Unresponsive to Methotrexate or Sulfasalazine
The purpose of this study is to evaluate the safety and efficacy of sirukumab as a single therapy in Japanese patients with moderately to severely active rheumatoid arthritis (RA) who have not responded to treatment with…
- Trial name
- NCT01689532
- Testing
- Sirukumab 100 mg, Sirukumab 50 mg
- Where
- 17 sites in Japan
- Volunteers
- 122 people
- Sponsor
- Janssen Pharmaceutical K.K.
Rheumatoid Arthritis
Self-injection of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis
The purpose of this study is to evaluate the long-term safety of subcutaneous (SC) self-injections (by the subject or subject's family member) of adalimumab in adult Japanese subjects with Rheumatoid Arthritis in an open-label…
- Trial name
- NCT00603993
- Testing
- Adalimumab
- Where
- 16 sites in Japan
- Volunteers
- 88 people
- Sponsor
- Abbott