Clinical trials: Joint Attention
Local Concentration of Tranexamic Acid Following Intra-articular Administration in TKA
In Vivo Study of Local Tranexamic Acid Concentrations Following Intra-Articular Administration in Total Knee Arthroplasty
The goal of this observational study is to measure local tranexamic acid (TXA) concentrations following intra-articular administration in patients undergoing total knee arthroplasty.
- Trial name
- NCT06876181
- Testing
- Pharmacokinetics of Intra-Articularly Administered TXA: Postoperative Concentration Dynamics in Periarticular Hematoma
- Where
- Slovenia
- Volunteers
- 48 people
- Sponsor
- Valdoltra Orthopedic Hospital
Autism Spectrum Disorder (ASD), Intellectual Disability
Verbal Intent and Gaze Cues on Action Prediction in ASD
A 2×2×3 mixed design (intent word × object type × group: TD, ASD, ID) was used. Age-matched children watched videos and judged which object a model would pick; their choices and eye movements were recorded.
- Trial name
- NCT07597694
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Rotator Cuff Related Shoulder Pain, Subacromial Pain Syndrome
The Effect of an Exercise Program Based on Attentional Focus Shifting on Clinical Outcomes in Rotator Cuff Related Shoulder Pain
The aim of this clinical trial is to investigate the effects of an attention shift-based rehabilitation program on clinical outcomes in individuals with rotator cuff-related shoulder pain (RCRSP).
- Conditions
- Rotator Cuff Related Shoulder Pain, Subacromial Pain Syndrome, Shoulder Bursitis, Shoulder Tendinopathy
- Trial name
- NCT07546084
- Testing
- Patient Education, Attention Shift-Based Exercise Therapy, Standard Exercise Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Autism Spectrum Disorder
Social and Communication Outcomes for Young Children With Autism
The goal of this project is to test an intervention program for caregivers and their young children with autism that is focused on improving social communication.
- Trial name
- NCT00953095
- Testing
- Joint Attention Intervention
- Where
- 5 sites in United States
- Volunteers
- 112 people
- Sponsor
- Health Resources and Services Administration (HRSA)
Joint Hypermobility, Balance
Muscle Strength and Balance in Individuals With Joint Hypermobility
Joint hypermobility is a clinical condition characterized by joints having a range of motion beyond their normal limits. Joint hypermobility (JH) makes the joints more vulnerable to trauma in individuals with increased joint…
- Conditions
- Joint Hypermobility, Balance, Muscle Strength
- Trial name
- NCT06202924
- Testing
- Static balance assessment, Dynamic balance assessment:, Isokinetic strength evaluation:
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Gazi University
Rheumatoid Arthritis
Study to Assess Steady-State Trough Concentrations, Safety, and Immunogenicity of Abatacept After Subcutaneous (SC) Administration to Subjects With Rheumatoid Arthritis (RA)
The purpose of this study is to study serum levels of Abatacept after subcutaneous dosing in subjects with RA.
- Trial name
- NCT00254293
- Testing
- Abatacept
- Where
- 5 sites in United States
- Volunteers
- 87 people
- Sponsor
- Bristol-Myers Squibb
Ofloxacin, Bone and Joint Infection
Ofloxacin Concentration-toxicity Relationship in the Elderly
Ofloxacin is a gold standard antibiotic for the treatment of bone and joint infections due to sensible staphylococcus strains. However, in the elderly, inter-individual variability of the pharmacokinetics may reduce the efficacy…
- Conditions
- Ofloxacin, Bone and Joint Infection, Therapeutic Drug Monitoring, Adverse Drug Reactions
- Trial name
- ROSCO (NCT04496024)
- Testing
- ofloxacin, questionnaire, Ofloxacin Serum concentration
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Rheumatoid Arthritis
Adalimumab Dose Reduction Aiming Low Serum Concentration With Control of Disease Activity
Several prior studies have shown that dose reduction or discontinuation of tumor necrosis factor (TNF)-inhibitors, like adalimumab, is possible in substantial number of patients with a rheumatic disease without an increase in…
- Trial name
- ADDORA-low (NCT04222920)
- Testing
- Dose reduction to 2mg/L, Dose reduction to 5mg/L, Adalimumab
- Where
- Netherlands
- Volunteers
- 78 people
- Sponsor
- Reade Rheumatology Research Institute
Rheumatoid Arthritis
Using Adalimumab Serum Concentration to Choose a Subsequent Biological DMARD in Rheumatoid Arthritis Patients Failing Adalimumab Treatment
A potential application of therapeutic drug monitoring is to predict efficacy after switch to another biological in the case of inefficacy of the previous TNF-inhibitor (TNFi) in rheumatoid arthritis (RA) patients.
- Trial name
- ADDORA-switch (NCT04251741)
- Testing
- Adalimumab trough concentration, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 86 people
- Sponsor
- Reade Rheumatology Research Institute
Knee Osteoarthritis
NSAID Treatment in Knee Osteoarthritis
Central mechanisms may play a role in pain perception during osteoarthritis (OA).Local inflammation (which involves production of pro-inflammatory cytokines such as interleukin (IL) 4 TNF-alpha, IL-6 and IL-8) is considered to be…
- Trial name
- NSKO (NCT01860833)
- Testing
- Ibuprofen, Celecoxib, Diclofenac
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Catanzaro
Arthralgia, Stiffness of Unspecified Joint, Not Elsewhere Classified
Comparative Study of Turmeric Extract in Patients With Arthrosis.
The aim of this study is to test if an extract of Turmeric can alleviate symptoms of osteoarthritis in volunteers with osteoarthritis of the hip and or knee.
- Conditions
- Arthralgia, Stiffness of Unspecified Joint, Not Elsewhere Classified, Disturbance of Activity and Attention, Quality of Life
- Trial name
- NCT04500210
- Testing
- Turmeric
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kaj Winther Hansen
Osteoarthritis, Rheumatoid Arthritis
Comparison of Rotating vs. Fixed Platform of the COLUMBUS Knee Prosthesis
A population of 100 patients randomised to rotating and fixed PE inlays in the Columbus knee prosthesis received a navigated TKR.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic; Arthrosis
- Trial name
- NCT00822640
- Testing
- Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Psoriasis, Colitis, Ulcerative
A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically
The purpose of this post-marketing study is to assess the amount of guselkumab in breast milk of lactating women receiving guselkumab as part of their standard clinical care provided by their treating physician, for any of the…
- Conditions
- Psoriasis, Colitis, Ulcerative, Crohn Disease, Arthritis, Psoriatic
- Trial name
- NCT07654751
- Testing
- Breast Milk Sample Collection, Guselkumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Janssen Research & Development, LLC
Anesthesia, Local
Serum Bupivacaine Concentration Levels After Injection of Liposomal Bupivacaine Into the Knee
Serum levels of bupivacaine over time after peri-articular injection of a mixture of liposomal bupivacaine and plain bupivacaine during total knee arthroplasty.
- Trial name
- NCT02626559
- Testing
- liposomal bupivacaine/plain bupivacaine peri-articular injection
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Utah
Blood Pressure, HDL Low
Effects of a 10 Component Dietary Supplement on Health and the Quality of Life
This open-label field trial evaluates the effects of treatment with a multi-pathway dietary supplement (Stem Cell 100+) that has been commercially available for several years.
- Conditions
- Blood Pressure, HDL Low, Stress, Lung Function Decreased
- Trial name
- NCT03052491
- Testing
- Stem Cell 100+
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centagen, Inc.
Crohn Disease, Ulcerative Colitis
The Evaluation of Injection Site Pain and Adherence in Patients Switching From a Low To High Concentration Adalimumab (AVT-02) Across Multiple Indications.
The purpose of the Phase IV study is to investigate the effects of both Volume and Citrate on Injection Site Pain (ISP), adherence, patient satisfaction, Quality of Life, and Disease Assessment in the Canadian Adalimumab Market.
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- EASE PAIN (NCT05913817)
- Testing
- AVT02 (Alvotech Biosimilar to Adalimumab)
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Jamp Pharma Corporation
Dry Eye, Keratoconjunctivitis Sicca
Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye
The purpose of this study is to compare the effects of autologous serum 20% and autologous serum 50% for the treatment of Severe Dry Eye Syndrome
- Conditions
- Dry Eye, Keratoconjunctivitis Sicca, Sjogren's Syndrome, Corneal Diseases
- Trial name
- NCT03436576
- Testing
- Autologous Serum 20%, Autologous Serum 50%
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Knee Osteoarthritis, Lower Extremity Biomechanics
Motor Learning in Knee Osteoarthritis
Non-surgical treatment options, like exercise therapy, show excellent short-term effects regarding pain reduction and improvement of knee function. However, mid- and long-term effects are missing so far.
- Conditions
- Knee Osteoarthritis, Lower Extremity Biomechanics, Physiotherapy
- Trial name
- MLKOA (NCT04445350)
- Testing
- External Focus Of Attention, Internal Focus Of Attention
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- St. Pölten University of Applied Sciences
Attention-Deficit Hyperactivity Disorder(ADHD)
A Trial to Evaluate the Efficacy and Safety of EB-1020 in Pediatric Patients With ADHD
The purpose of this study is to evaluate the efficacy and examine the safety of two doses of EB-1020 QD XR capsule administered once daily orally in pediatric ADHD patients.
- Trial name
- NCT07086313
- Testing
- EB-1020 (Centanafadine) low dose, EB-1020 (Centanafadine) high dose
- Where
- Japan
- Volunteers
- 315 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.