Clinical trials: Joint Osteoarthritis
Osteoarthritis Knee
Integrated Treatment Program for Osteoarthritis of the Knee
The purpose of this study is to determine the ability to assimilate and implement an integrated treatment program osteoarthritis of the knee, including the diagnosis and follow-up by a family physician in primary care clinics…
- Trial name
- NCT02200107
- Testing
- self management education
- Where
- Israel
- Volunteers
- 155 people
- Sponsor
- Meir Medical Center
Rheumatoid Arthritis, Synovial Disorder
Study of the Articular Microbiota in Rheumatoid Arthritis.
The cause of rheumatoid arthritis (RA) remains unknown, although major advances have been done these last ten years in the comprehension of its pathophysiology.
- Conditions
- Rheumatoid Arthritis, Synovial Disorder, Arthrosis
- Trial name
- MICROPORE (NCT04056234)
- Testing
- Joint puncture
- Volunteers
- 36 people
- Sponsor
- University Hospital, Bordeaux
Knee Osteoarthritis
Electromyographic Biofeedback on Performance of Vastus Medialis Oblique Muscle in Knee Osteoarthritis
This study intends to determine the Effects of Electromyographic biofeedback on performance of vastus medialis oblique muscle in knee osteoarthritis.
- Trial name
- NCT04194853
- Testing
- Electromyographic Biofeedback, Quadriceps Isometric exercises
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Knee Osteoarthritis
Shock Wave Treatment in Patients With Knee Osteoarthritis
Introduction: Knee osteoarthritis represents a significant health problem due to its impact on the functionality and quality of life of patients. Its treatment can be pharmacological, non-pharmacological, or surgical.
- Trial name
- SWKO (NCT07125430)
- Testing
- strengthening exercise, shock wave
- Where
- 2 sites in Spain
- Sponsor
- Guadarrama Hospital
Osteoarthritis, OA
Comparing X-3 To N2vac Polyethylene With the Triathlon Total Knee System
Methodology: This study will be a randomized, multi-center evaluation comparing N2vac polyethylene inserts and patellas with X3 inserts and patellas when used in the Triathlon PS total knee system.
- Trial name
- NCT00665964
- Testing
- X-3 polyethylene, N2Vac polethylene
- Where
- Canada
- Sponsor
- Dalhousie University
Osteoarthritis, Knee
Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain
Phase I/IIa study to determine the safety and clinical effects of intra-articular injections of MTX-071 (Lopain) in patients with chronic osteoarthritic knee-joint pain.
- Trial name
- NCT02566564
- Testing
- Lopain
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis
Closed Suction Drainage in Shoulder Arthroplasty
The purpose of this study is to determine the limited effectiveness of drains during Total Shoulder Arthroplasty. Drains are used during joint arthroplasty procedures to decrease infection rates, swelling,and the number of…
- Trial name
- NCT02767453
- Testing
- Wound drainage, Total Shoulder Arthroplasty
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University
Osteoarthritis, Knee
Investigation of Predisposing Factors Affecting Pain in Patients With Knee Osteoarthritis
This study aims to determine the factors affecting pain in patients with knee osteoarthritis (OA). This study will be carried out following the "Helsinki Declaration", by selecting 106 volunteers who were diagnosed with knee OA…
- Trial name
- NCT05238857
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Istanbul University
Osteoarthritis
Efficacy Study of PN400 (VIMOVO) Twice Daily and Celebrex Once Daily in Patients With Osteoarthritis
We will evaluate the efficacy of PN 400 and an active comparator in patients that have Osteoarthritis of the knee.
- Trial name
- NCT00665431
- Testing
- PN 400 (VIMOVO), celebrex, Rescue Antacid
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- POZEN
Knee Osteoarthritis
Biopsychosocial Assessment in Knee OA
Background: Patient's pain experience is a complex phenomenon. A comprehensive clinical assessment of the patient's pain experience is helpful to define individual differences between patients and thus to plan effective…
- Trial name
- BioPsyOA (NCT05734131)
- Testing
- Bio-psychosocial assessment
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Obesity (Disorder), Knee Osteoarthritis (Knee OA)
Effects of Resveratrol Supplementation Combined With a Low-Calorie Diet in Postmenopausal Women With Obesity and Knee Osteoarthritis
Obesity is a major modifiable risk factor for knee osteoarthritis and is associated with chronic low-grade inflammation, pain, functional impairment, and cartilage degradation.
- Trial name
- ERSOKO (NCT07634302)
- Testing
- Trans-resveratrol extract from Polygonum Cuspidatum, Low-Calorie Diet
- Where
- Russia
- Volunteers
- 97 people
- Sponsor
- Federal State Budgetary Scientific Institution
Knee Osteoarthritis
Balneotherapy With Acquabios Thermal Water in Knee Osteoarthritis
The aim of the study is the evaluation of the effect of balneotherapy with Acquabios bicarbonate-alkaline-sodium thermal water in ameliorating some signs and symptoms of knee osteoarthritis in human subjects suffering from this…
- Trial name
- NCT05352477
- Testing
- Balneotherapy with thermal water, Balneotherapy with tap water
- Volunteers
- 88 people
- Sponsor
- University of Roma La Sapienza
Osteoarthritis of Knee
Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)
This phase III clinical study will be conducted in Brazilian research sites. It will be included in the study 314 participants diagnosed with primary knee OA according to the classification criteria of the ACR.
- Trial name
- GLACIAL (NCT02830919)
- Testing
- Glucosamine and chondroitin sulfate combination (Eurofarma), Glucosamine and chondroitin sulfate combination (Zodic)
- Where
- 4 sites in Brazil
- Volunteers
- 627 people
- Sponsor
- Eurofarma Laboratorios S.A.
Osteoarthritis, Knee
Safety and Efficacy of the Journey II BCS Total Knee System
Assess the safety and efficacy of the JOURNEY II BCS Total Knee System in subjects with degenerative knee disease requiring primary total knee replacement.
- Trial name
- NIMBLE (NCT01705067)
- Testing
- TKA with Journey II BCS Total Knee System
- Where
- 12 sites in United States
- Volunteers
- 209 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee
A Long-Term Safety and Efficacy Study of Lorecivivint in Subjects With Osteoarthritis of the Knee
Study OA-07 was a randomized, double-blind, placebo-controlled, Phase 3, multicenter, 2-year clinical trial that enrolled subjects from the recently completed Study OA-11 (NCT03928184).
- Trial name
- NCT04520607
- Testing
- Lorecivivint
- Where
- 42 sites in United States
- Volunteers
- 276 people
- Sponsor
- Biosplice Therapeutics, Inc.
Knee Osteoarthritis
Strengthening Exercise and Quadriceps Force During Walking
This is a longitudinal, randomized, controlled interventional multi centric study on the effects of lower leg strengthening exercise on quadriceps force during walking in people with knee osteoarthritis.
- Trial name
- NCT01538407
- Testing
- Strength Training
- Where
- 2 sites in United States, Denmark
- Volunteers
- 30 people
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis
Efficacy & Safety Study Evaluating Natural Eggshell Membrane (NEM) in the Treatment of Osteoarthritis
The purpose of this study is to evaluate the effectiveness of Natural Eggshell Membrane (NEM) for the relief of pain and stiffness associated with moderate osteoarthritis of the knee and to compare the effectiveness of NEM to…
- Trial name
- OPTION (NCT00750477)
- Testing
- NEM
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- ESM Technologies, LLC
Osteoarthritis, Spinal Arthritis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for OA
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells delivered intravenously and intraarticularly for the treatment of Osteoarthritis.
- Trial name
- NCT05147675
- Testing
- AlloRx
- Where
- 2 sites in United States, Greece
- Volunteers
- 92 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Osteoarthritis
A Study to Determine if Aquamin Modulates Inflammatory Biomarkers in the Blood of Osteoarthritis and Healthy Subjects
Osteoarthritis (OA) is the most common kind of arthritis and primarily affects the large, weight bearing joints (including the knees, lower back, hips, neck and the feet) and the joints in the hands.
- Trial name
- NCT01321281
- Testing
- AquaCal, AquaPT
- Where
- Ireland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Andrea Doolan
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-I (NCT02928471)
- Testing
- Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Henrik Gudbergsen