Clinical trials: Juvenile
Juvenile Idiopathic Arthritis
Virtual Peer-to-Peer (VP2P) Support Mentoring for Juvenile Idiopathic Arthritis (JIA): A Pilot RCT
Study Hypothesis: A virtual peer-to-peer support intervention will improve health outcomes and quality of life in adolescents with Juvenile Idiopathic Arthritis
- Trial name
- NCT01986400
- Testing
- Virtual Peer-to-Peer Support Mentoring
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Niemann-Pick Type C Disease
Miglustat in Niemann-Pick Type C Disease
This is a phase II randomized controlled study of miglustat in adult and juvenile patients with Niemann-Pick Type C disease. Up to 42 patients will be randomised in a 2:1 ratio to either treatment with miglustat or to a…
- Trial name
- NCT00517153
- Testing
- miglustat
- Volunteers
- 29 people
- Sponsor
- Actelion
Epidemiology
Juvenile Idiopathic Arthritis in Children in Estonia.
Aims of the study: to study the incidence rate of juvenile idiopathic arthritis (JIA) and it's clinical subtypes in Estonia for the years 1998-2000; to examine the course and short-term clinical outcome of JIA.
- Trial name
- NCT01905319
- Testing
- Blood collecting for storage of samples
- Volunteers
- 162 people
- Sponsor
- University of Tartu
Cancer
Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections
RATIONALE: White blood cells that have been treated in the laboratory may kill cells that are infected with cytomegalovirus. PURPOSE: This phase I trial is studying how well cytotoxic T cells work in treating patients who have…
- Trial name
- NCT00769613
- Testing
- cytomegalovirus IE-1-specific cytotoxic T lymphocytes, cytomegalovirus pp65-specific cytotoxic T lymphocytes, therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Immune-Mediated Necrotizing Myopathy
Juvenile Autoimmune Necrotizing Myopathies
Autoimmune necrotizing myopathies (AINM) in adult patients are characterized by severity of muscle damage, presence of necrosis with little inflammation on muscle biopsy and anti-HMGCR or anti-SRP auto-antibodies.
- Trial name
- MYONECPED (NCT04295785)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Central Hospital, Nancy, France
Polycystic Ovary Syndrome, Adolescent Behavior
Adolescent Polycystic Ovary Syndrome on a Low-carbohydrate Diet
The aim of the study was to investigate the changes in the clinical and biochemical parameters of adolescents on a low-carbohydrate diet in relation to their PCOS phenotype in the 3rd trimester.
- Conditions
- Polycystic Ovary Syndrome, Adolescent Behavior, Diet Habit
- Trial name
- PCOS (NCT06429618)
- Testing
- Low carbonhydrate diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Acute Myeloid Leukemia, Juvenile Myelomonocytic Leukemia
Allogenic Stem Cell Transplantation in Patients With High Risk CD33+ AML/MDS/JMML
The addition of gemtuzumab ozogamicin (GO) in combination with Busulfan/Cyclophosphamide followed by AlloSCT in patients with high risk CD33+ AML/JMML/MDS will be safe and well tolerated.
- Conditions
- Acute Myeloid Leukemia, Juvenile Myelomonocytic Leukemia, Myelodysplastic Syndrome
- Trial name
- High Risk (NCT00669890)
- Testing
- Gemtuzumab Ozogamicin, Busulfan, Cyclophosphamide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York Medical College
Immune Thrombocytopenic Purpura ( ITP ), Systemic Lupus Erythematosus (SLE)
Modeling the Early Stages of Autoimmunity Through the Study of Immunological Thrombocytopenic Purpura and Juvenile Lupus
Immunologic thrombocytopenic purpura (ITP) in children is a pre-lupus condition if associated with the presence of anti-nuclear antibodies (ANA), providing a unique model for understanding the natural history of autoimmunity…
- Trial name
- PRELUDE (NCT07680010)
- Testing
- Blood sampling baseline and M3, Monitoring for SLE, Procedure/Surgery: Blood sampling baseline and M3 then each 6 months until 48 months
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Juvenile Idiopathic Arthritis, Tenosynovitis
Tenosynovitis in Polyarticular and Oligoarticular Juvenile Idiopathic Arthritis
Juvenile Idiopathic Arthritis (JIA) is a chronic condition that causes joint inflammation in children. In some cases, the inflammation also affects the protective sheath surrounding the tendons, a condition known as…
- Conditions
- Juvenile Idiopathic Arthritis, Tenosynovitis, Polyarticular Juvenile Idiopathic Arthritis, Oligoarticular Juvenile Idiopathic Arthritis
- Trial name
- NCT07553910
- Volunteers
- 106 people
- Sponsor
- Assiut University
SARS Cov 2 Vaccination in Adolescents With Juvenile Idiopathic Arthritis
SARS Cov 2 Vaccination in Adolescents With Juvenile Idiopathic Arthritis
Since june 2021, vaccination against the SARS-Cov2 virus is recommanded in France to all children from 12 to 18 years old. In the specific population of teenagers living with juvenile arthritis, the vaccine seems to be safe and…
- Trial name
- VACOVAJI (NCT05547451)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
JIA, Self-Evaluation
Using Self-evaluation to Increase Visit Intervals in Juvenile Idiopathic Arthritis
In the THUIS study, JIA patients in clinical remission will skip one 3-monthly hospital control visit and instead monitor their disease activity at home. Outcomes at 6 months will be compared to those from a historical cohort.
- Trial name
- THUIS (NCT05603286)
- Testing
- Home-monitoring
- Where
- Netherlands
- Volunteers
- 85 people
- Sponsor
- Joeri van Straalen
Macrophage Activation Syndrome, Lymphohistiocytosis, Hemophagocytic
New Candidate Criteria for Diagnosis of Macrophage Activation Syndrome
Macrophage activation syndrome(MAS) is a complication of bone marrow suppression, coagulopathy and CNS dysfunction which occurs in rheumatic diseases.
- Trial name
- MAS-D (NCT01095146)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Arthritis, Juvenile
Sleep & Pain in Juvenile Arthritis
Childhood arthritis is an important cause of pain for affected children and youth (adolescents). Many youth with arthritis also have trouble sleeping.
- Trial name
- NCT04133662
- Testing
- Sleep Manipulation Protocol
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- The Hospital for Sick Children
Juvenile Idiopathic Arthritis (JIA), Familial Mediterranean Fever (FMF )
Gait Profile and Variables in Pediatric Rheumatic Disease Using a Smart Insole System
In pediatric rheumatic diseases, joint swelling, effusion, tenderness, and painful restriction of joint movement, particularly in weight-bearing joints, frequently alter walking function.
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Familial Mediterranean Fever (FMF ), Healthy Controls
- Trial name
- NCT06705673
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Macrophage Activation Syndrome (MAS), Still Disease, Juvenile Onset
Assessment of Macrophage Activation syndromE in STill's Disease in Italy
Assessment of macrophage activation syndrome in Still's disease: retrospective chart analysis of patient history, symptom resolution and treatment characteristics in Italy
- Conditions
- Macrophage Activation Syndrome (MAS), Still Disease, Juvenile Onset, Still's Disease, Adult-Onset
- Trial name
- AMETISTA (NCT06992505)
- Where
- 2 sites in Italy
- Volunteers
- 32 people
- Sponsor
- Swedish Orphan Biovitrum
Juvenile Idiopathic Arthritis
A Study of Tocilizumab in Chinese Participants With Systemic Juvenile Idiopathic Arthritis (sJIA)
This Phase IV, multicenter, single-arm, open-label study will evaluate the efficacy and safety of tocilizumab in Chinese participants with sJIA with persistent activity and an inadequate response to non-steroidal…
- Trial name
- NCT03301883
- Testing
- Tocilizumab, NSAIDs, CSs
- Where
- 10 sites in China
- Volunteers
- 62 people
- Sponsor
- Hoffmann-La Roche
Systemic Juvenile Idiopathic Arthritis
Study of MRA for Polyarticular Juvenile Idiopathic Arthritis (pJIA)
This is an open-label, Phase III study to evaluate the efficacy, safety and PK of MRA in patients with pJIA.
- Trial name
- NCT00144664
- Testing
- MRA(Tocilizumab)
- Volunteers
- 19 people
- Sponsor
- Chugai Pharmaceutical
Juvenile Osteochondrosis of Spine
Sling Suspension Versus Gym Balls in the Treatment of Juvenile Spinal Osteochondrosis
This study compares effect of swiss ball exercises with sling suspension exercises in the treatment of juvenile osteochondrosis in adolescent-girls
- Trial name
- NCT03851367
- Testing
- Sling suspension using red cord, Gym ball exercises
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- Lithuanian Sports University
Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma
Testing a Reading Module to Improve Reading Skills and Quality of Life in Glaucoma Patients
The goal of this interventional study is to test the effectiveness of reading rehabilitation module towards reading speed and error, and quality of life in glaucoma patients.The main questions it aims to answer are: 1.
- Conditions
- Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma, Normotensive Glaucoma, Primary Angle Closure Glaucoma
- Trial name
- NCT07741812
- Testing
- Reading Rehabilitation Module
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sains Malaysia
Still's Disease, Adult-Onset, Still's Disease, Juvenile-Onset
A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD)
The aim of this study is to demonstrate the efficacy and to evaluate the safety, pharmacokinetics (PK) and immunogenicity of anakinra in patients with newly diagnosed Still's disease, including SJIA (Systemic juvenile idiopathic…
- Trial name
- anaSTILLs (NCT03265132)
- Testing
- anakinra
- Where
- 39 sites in United States, Canada
- Volunteers
- 13 people
- Sponsor
- Swedish Orphan Biovitrum