Clinical trials: Juvenile Diabetes
Type 1 Diabetes
Non-inferiority Study to Compare the Efficacy and Safety of Mylan's Insulin Glargine With Lantus® in Type 1 Diabetes Mellitus Patients (INSTRIDE 1)
To test whether Mylan's insulin glargine once daily is non-inferior to Lantus® once daily (based on change in HbA1c from baseline to 24 weeks) when administered in combination with mealtime insulin lispro.
- Trial name
- INSTRIDE 1 (NCT02227862)
- Testing
- Mylan's insulin glargine, Lantus®
- Where
- 162 sites in United States, Canada and 9 more
- Volunteers
- 558 people
- Sponsor
- Mylan Inc.
type1diabetes, Type2 Diabetes
Efficacy and Safety of Recombinant Human Insulin Patch ZJSRM2021
The aim of this study is to investigate the efficacy，safety， and tolerability of the recombinant human insulin patch ZJSRM2021 in healthy subjects, type 1diabetes mellitus and type 2diabetes mellitus patients
- Trial name
- NCT05089942
- Testing
- Recombinant Human Insulin Patch ZJSRM2021
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial People's Hospital
Kidney Transplant; Complications, Diabetes Mellitus, Type 2
Use of CGM in Kidney Transplant Recipients
The investigators want to study the impact CGM (continuous glucose monitoring) has on patients glycemic control as determined by time in range (TIR 70-180 mg/dL) in the Diabetic Kidney Transplant population.
- Conditions
- Kidney Transplant; Complications, Diabetes Mellitus, Type 2, Insulin Dependent Diabetes
- Trial name
- NCT04783441
- Testing
- Dexcom G6, Dexcom G6 blinded sensor
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Davis
Type 1 Diabetes
Obtain a Good Blood Glucose Control With the Paradigm Real Time System
In this study, subjects with insufficient metabolic control despite optimized basal-bolus injection regimens were randomily assigned to either the Mini- Med Paradigm REAL-Time insulin pump (PRT), an insulin pump that can receive…
- Trial name
- RTD (NCT00441129)
- Testing
- Minimed paradigm Real Time Sytem, Minimed Paradigm 512/712 Insulin pump
- Where
- 8 sites in France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Medtronic MiniMed, Inc.
Presymptomatic Diabetes Type 1 (Stage 1), Diabetes Mellitus, Type I
Treatment of Presymptomatic (Stage 1) Type 1 Diabetes Pediatric Patients With Treg Cell Preparations and Anti-CD20 Antibody
The main purpose of the study is to check: Can therapy with a preparation of regulatory cells (Tregs lymphocytes) and/or an anti-CD20 antibody preparation (rituximab) be successfully used in children with pre-diabetes to treat or…
- Conditions
- Presymptomatic Diabetes Type 1 (Stage 1), Diabetes Mellitus, Type I, Diabetes Mellitus, Type 1
- Trial name
- PreTreg (NCT06688331)
- Testing
- ex vivo expanded CD4+CD25+CD127- regulatory T cells (Tregs), Anti-CD20 (rituximab)
- Where
- 9 sites in Poland
- Volunteers
- 150 people
- Sponsor
- PolTREG S.A.
Type 1 Diabetes Mellitus
Best Timing of Insulin Bolus Before Meals of Different Contents
Post-meal glucose excursions may contribute to the development of diabetes-related complications. These glucose excursions are affected by the food content of the meal and the timing of insulin injection (or insulin pump-bolus)…
- Trial name
- NCT01406496
- Testing
- insulin
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Diabetes Mellitus, Type 1
Factors in Accuracy Studies Influencing Measured CGM Performance.
Primary objective is to assess the impact of different reference glucose measurement methods on the measured performance of a CGM system, aiming at further standardization for the assessment of CGM systems.
- Trial name
- FACT-CGM (NCT02843503)
- Testing
- Arterialized-venous reference (YSI), Venous reference measurement (YSI), Capillary reference (SMBG)
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Type 1 Diabetes
Safety Evaluation of the Hybrid Closed Loop (HCL) System in Pediatric Subjects With Type 1 Diabetes
This study is a single-arm, multi-center, Home and Hotel Clinical Investigation in pediatric subjects with type 1 diabetes on insulin pump therapy.
- Trial name
- NCT02660827
- Testing
- Insulin Pump
- Where
- 11 sites in United States, Israel
- Volunteers
- 151 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetic Children
IgE-mediated Allergies Among Type 1 Diabetes Mellitus Children, Single Centre Observational Study
an interviewer-administrated questionnaire was designed to take history of allergy in diabetic child come to outpatient clinic fulfilling inclusion criteria and used to collect data.
- Trial name
- NCT05596656
- Testing
- skin prick test
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University Children Hospital
Diabetes, Type 1
Safety and Efficacy of Technosphere® Insulin Inhalation Powder and Lantus® Compared to Humalog® and Lantus® Over 16-Weeks
The objective of this study is to demonstrate that TI® Inhalation Powder combined with Lantus® is as effective as Humalog® combined with Lantus® on HbA1c.
- Trial name
- NCT00700622
- Testing
- Technosphere Insulin, Insulin glargine, Insulin lispro
- Where
- 22 sites in United States, Brazil
- Volunteers
- 130 people
- Sponsor
- Mannkind Corporation
Type1diabetes
Assay for the Pancreatic Polypeptide: an Help for Clinical Practice Guidelines in Classification of the Diabetes
The purpose of this study is to evaluate global endocrine function within type 1 and type 3c diabetic patients, helping pancreatic polypeptide measurement.
- Trial name
- DIAPP (NCT03396146)
- Testing
- 12 ml total blood tubes volume, Fecal sample
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes Mellitus, Pregnancy
Orchestra Pregnancy Observational Study in Poland
The aim of this project is to document the use of insulin pump therapy (CSII), including sensor augmented pump therapy (SAP), before, during and after pregnancy in women with type 1 Diabetes Mellitus benefiting from the Orchestra…
- Trial name
- NCT01779141
- Where
- 24 sites in Poland
- Volunteers
- 481 people
- Sponsor
- Medtronic MiniMed, Inc.
Wolfram Syndrome 1, Optic Atrophies, Hereditary
Does Recessive Optic Atrophy Due to WFS1 Exist?
All patients with Wolfram syndrome and recessive optic atrophy due to a mutation of the WFS1 from a single Center were included in a retrospective study.
- Trial name
- NCT07336966
- Testing
- analyse study
- Volunteers
- 45 people
- Sponsor
- Hôpital Necker-Enfants Malades
TYPE 1 DIABETES
β-cell Function in Type 1 Diabetes May Not Be As Low As Presumed
Enhancing endogenous insulin production in type 1 diabetic patients (T1DP) can improve glycemic control and decrease complications and rates of mortality.
- Trial name
- NCT02199470
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Gonca Incemehmet Tamer
Primary Biliary Cirrhosis
Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis
The purpose of this study is to determine if abatacept (Orencia) is effective in patients with primary biliary cirrhosis who do not respond adequately to standard treatment with ursodeoxycholic acid (UDCA, Urso, Ursodiol…
- Trial name
- PBC (NCT02078882)
- Testing
- abatacept
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Christopher Bowlus, MD
Diabetes Mellitus, Type 1
Avoidance of Hyperglycaemia in People With Type 1 Diabetes
This study aims to learn more about avoidance of hyperglycaemia in adults with type 1 diabetes. People who attend a type 1 diabetes clinic will be invited to complete a number of self-report questionnaires and a survey.
- Trial name
- HYPE (NCT04732780)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 253 people
- Sponsor
- Imperial College London
Type 1 Diabetes
Insulin Analogues and Severe Hypoglycaemia
Severe hypoglycaemia is hampering the lives of many diabetic patients. The effect on the occurrence of severe hypoglycaemia during two different insulin regimens are to be investigated.
- Trial name
- NCT00346996
- Testing
- insulin levemir / aspart, human insulin /insulin isophane
- Where
- Denmark
- Volunteers
- 179 people
- Sponsor
- Lise Tarnow
Type 1 Diabetes
ACT Stress Management in Type 1 Diabetes
For many people living with type 1 diabetes it is a challenge to achieve good glucose control. Barely 20% reaches the goal level and many people experience self-care as complex, demanding and stressful.
- Trial name
- NCT02914496
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- Sweden
- Volunteers
- 81 people
- Sponsor
- Karolinska Institutet
Type 1 Diabetes Mellitus
A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus
The main purpose of this study is to evaluate the effect of excipients sodium citrate and treprostinil without insulin on local infusion site pain in participants with type 1 diabetes mellitus (T1DM) on continuous subcutaneous…
- Trial name
- NCT05067270
- Testing
- Sodium Citrate, Treprostinil, Humalog diluent
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1, Diabetes Distress
Use of an Online Intervention for the Treatment of Diabetes Distress in Patients With Type 1-Diabetes
This study will investigate whether an online intervention can be helpful in reducing diabetes distress in people with type 1 diabetes and elevated diabetes distress, compared to individual counselling sessions (online…
- Trial name
- NCT06436456
- Testing
- Online psychological intervention, Individual psychological intervention
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital