Clinical trials: Juvenile-Onset Diabetes
Type 1 Diabetes
Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes
This project is designed to study the role of vitamin D supplementation on the honeymoon phase of type 1 diabetes in children who are on standardized insulin treatment.
- Trial name
- PCR (NCT03046927)
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Benjamin U. Nwosu, MD
Type 1 Diabetes Mellitus
Closing the Loop in Adults With Type 1 Diabetes in the Home Setting
The main study objective is to compare real-time continuous subcutaneous glucose monitoring (CGM) combined with overnight automated closed-loop glucose control, and real-time CGM alone in the home setting.
- Trial name
- NCT01440140
- Testing
- Closed-loop, Conventional insulin pump delivery
- Where
- 3 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Cambridge
Type 1 Diabetes
Effect of the InsuPatch on Automated Closed-loop Glucose Control in Type 1 Diabetes
This research study designed to look at how well adolescents' and young adults' blood sugars can be controlled with a "closed loop artificial pancreas" using a continuous glucose sensor, an insulin pump, and a computer program…
- Trial name
- IPCL (NCT01787318)
- Testing
- ePID closed loop system, InsuPatch
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Type1diabetes, Adolescent Behavior
Sleep, Glycemic Control, and Insulin Resistance in Adolescents With Type 1 Diabetes
Despite advancements in care, most adolescents with T1D have higher BMI and significantly higher HbA1c than recommended and are markedly IR, placing them at increased risk for CVD1,2.
- Conditions
- Type1diabetes, Adolescent Behavior, Sleep
- Trial name
- SunDIAL (NCT03832790)
- Testing
- observation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
A Performance Evaluation of the Enlite 3 Sensor
The purpose of this study is to support the use of the Enlite 3 sensor in arm and thigh in subjects age 14 - 75 years and provide additional characterization of the Enlite 3 sensor performance in arm in subjects age 14 - 75 years.
- Trial name
- NCT02649010
- Testing
- Enlite 3 Sensor
- Where
- 2 sites in United States
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus With Hypoglycemia, Impaired Awareness of Hypoglycemia
Impact on Hypoglycaemia Awareness of Real Time CGM and Intermittent Continuous Glucose Data
This clinical study proposes to assess the impact of Libre on frequency, duration and severity of hypoglycaemia, compared with the Dexcom G5 realtime CGM and will focus on people with impaired awareness of hypoglycaemia.
- Conditions
- Type 1 Diabetes Mellitus With Hypoglycemia, Impaired Awareness of Hypoglycemia, Type1diabetes
- Trial name
- IHART-CGM (NCT03028220)
- Testing
- Dexcom G5 Continuous Glucose Monitor, Abbott Freestyle Libre
- Volunteers
- 40 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 1
Study of the Impact of PROximity Support for Patients With Type 1 DIABetes Treated With an Insulin Pump or Closed Loop.
Amidst medical innovations, many Type 1 diabetes patients using advanced therapy show improved control but still suffer from diabetes-related distress.
- Trial name
- PRO-DIAB-1 (NCT06050642)
- Testing
- enhanced care model provided by Timkl, a home support provider
- Where
- France
- Volunteers
- 340 people
- Sponsor
- timkl
Type 2 Diabetes Mellitus (T2DM), Type 1 Diabetes Mellitus (T1DM)
Continuous Glucose Monitoring for Outpatient Diabetes Management After Hospital Discharge
This study aims to improve patient awareness of the utility of continuous glucose monitoring systems in blood glucose monitoring and to improve patient satisfaction regarding diabetes care, particularly in the matter of blood…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type 1 Diabetes Mellitus (T1DM), Hyperglycemia
- Trial name
- NCT06852950
- Testing
- Libre 3 Plus Continuous Glucose Monitor, Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home
The purpose of this study is to evaluate the safety and effectiveness of the Hybrid Closed Loop system (HCL) in adult and pediatric patients with type 1 diabetes in the home setting.
- Trial name
- NCT02748018
- Testing
- 670G and 770G Insulin Pump, Subject's Current Diabetes Therapy
- Where
- 36 sites in United States, Canada and 7 more
- Volunteers
- 959 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes, Insulin
The Use of Faster Acting Aspart in Type 1 Diabetes Patients
Data on switching from traditional mealtime insulins to fast-acting insulin aspart (Fiasp) in routine clinical practice are sparse.
- Conditions
- Type 1 Diabetes, Insulin, Time in Range
- Trial name
- NCT04711382
- Where
- Belgium
- Volunteers
- 438 people
- Sponsor
- University Hospital, Antwerp
Diabetes, Diabetic Foot
Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care
This is a two-armed randomized controlled trial (RCT) primarily aimed at determining if application of Cytal Wound Matrix 1-Layer intervention to diabetic foot ulcers shows improved wound closure rates when compared to standard…
- Conditions
- Diabetes, Diabetic Foot, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03626623
- Testing
- Cytal Wound Matrix 1-Layer, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Integra LifeSciences Corporation
Type 1 Diabetes
Rapamycin Versus Mycophenolate Mofetil in Kidney-Pancreas Recipients
This study was designed to determine which maintenance immunosuppressive agent, rapamycin or mycophenalate mofetil, resulted in better outcome in patients with type 1 diabetes and renal failure, who presented for a…
- Trial name
- NCT00533442
- Testing
- Rapamycin, Mycophenolate Mofetil, Tacrolimus
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- University of Miami
Type 1 Diabetes
To Evaluate add-on Effect of Nisha-Amalaki Tablets Along With Insulin on Glycemic Control in Type 1 Diabetes Patients (RCTNA)
Type-I diabetes mellitus (T1DM) is an autoimmune condition, in which the pancreas reduces/stops insulin production. Patients with T DM have to take insulin injections with every meal and also usually a long-acting preparation.
- Trial name
- NCT06487598
- Testing
- inj insulin to one group, Inj Insulin with Tab Nisha-Amalaki 500 mg twice a day
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Hirabai Cowasji Jehangir Medical Research Institute
Diabetes, Diabetes Mellitus, Type 1
Observational Study of Type 1 and Type 2 Diabetes Patients Having Switched From Human Premixes to NovoMix®30
This trial is conducted in Europe. The aim of this observational study is to evaluate the blood glucose control (HbA1c) using NovoMix® 30 for treatment of type 1 and type 2 diabetes under normal clinical practice conditions in…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00675493
- Testing
- biphasic insulin aspart 30
- Where
- Romania
- Volunteers
- 942 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Exercise and the Menstrual Cycle in Type 1 Diabetes
Female participants with type 1 diabetes using oral contraceptives will be asked to wear a continuous glucose monitor for at least three days on two separate occasions (once during the last week of active pills and once during…
- Trial name
- NCT05188014
- Testing
- Luteal Phase Aerobic Exercise, Follicular Phase Aerobic Exercise
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Feasibility Study of Family Teamwork Peer-Delivery
The purpose of this study is to 1) convene African American and Latino Community Coalitions to adapt Family Teamwork (FT) for school-age youth, and integrate FT with the Smart and Secure Children (SSC) program community-based…
- Trial name
- TEAM (NCT04053504)
- Testing
- Family Teamwork-Peer Delivery
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Self Care
Evaluation of the Eversense Continuous Glucose Monitoring System in Type I Diabetic Youth
The purpose of this clinical investigation is to provide pilot clinical data to direct pivotal study development for the pediatric indication of the Senseonics Continuous Glucose Monitoring System (CGM) measurements when compared…
- Trial name
- FNH (NCT03815552)
- Testing
- Eversense Continuous Glucose Monitoring
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes Mellitus
Does Protein and Fat Content of Meal Increase Glucose Concentrations
The study investigated the effects of fat protein counting (CFP) in addition to carbohydrate (CARB) counting for calculating prandial insulin dosage on blood glucose profile in patients with type 1 diabetes (T1D) on basal-bolus…
- Trial name
- NCT03333525
- Testing
- Calculation of insulin dosages for different meals
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus With Hypoglycemia
Glycemic Excursions in Patients With Type 1 Diabetes Mellitus Using Closed-loop Systems
The study aims to compare glycemic excursions during several life situations (such as periods of driving, periods of night sleep, periods of occupation, periods of physical activity, and periods of stress) in patients with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus With Hypoglycemia, Drive
- Trial name
- SAFEDRIVE (NCT06382350)
- Testing
- MiniMed 780 G
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital, Motol
Type 1 Diabetes
Use of the Paradigm 722 System to Improve Glycemic Control in Adult and Adolescent Subjects With Type 1 Diabetes
The purpose of this study is to determine whether Type 1 Diabetic subjects using the Paradigm 722 System, which is a glucose sensor-augmented insulin pump, can improve glycemic control when compared to subjects using the Paradigm…
- Trial name
- STAR1 (NCT00211510)
- Testing
- Paradigm 722 sensor augmented pump, Paradigm 715 insulin pump
- Where
- 7 sites in United States
- Volunteers
- 146 people
- Sponsor
- Medtronic MiniMed, Inc.
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