Clinical trials: Juvenile-Onset Diabetes
Glucose, Low Blood, Glucose, High Blood
Dose Safety Hybrid Closed Loop and Fully Automated Closed Loop Artificial Pancreas Device in CRC
The objective of this study is to test two different operating modes of the latest version of the Dose Safety artificial pancreas system (APS), the Dose Safety Controller (DSC version 2.3), in a population of subjects with type 1…
- Trial name
- NCT03428295
- Testing
- Dose Safety AP system
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dose Safety Inc.
Type 1 Diabetes Mellitus
Frexalimab in Preservation of Endogenous Insulin Secretion Compared to Placebo in Adults and Adolescents on Top of Insulin Therapy (FABULINUS)
This is a randomized, parallel group, double-blind Phase 2 study with a blinded extension evaluating the safety and efficacy of 3 dose levels of frexalimab in comparison with placebo in participants with newly diagnosed T1D on…
- Trial name
- FABULINUS (NCT06111586)
- Testing
- Frexalimab, Insulin
- Where
- 79 sites in United States, Austria and 14 more
- Volunteers
- 197 people
- Sponsor
- Sanofi
Type1diabetes, Metabolic Syndrome
The Effect of Exercise on Metabolic Parameters, Anthropometric Measurement Values and Quality of Life
This study was planned as a randomized controlled experimental study to determine the effect of exercise with Augmented Reality Glasses (AR) on metabolic parameters, anthropometric measurement values and quality of life in…
- Conditions
- Type1diabetes, Metabolic Syndrome, Nursing Caries
- Trial name
- NCT05737654
- Testing
- Exercise with augmented reality glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
Diabetes Mellitus, Type 1
A Pilot Study of Biomarkers of Stress in Youth Who Use Teens.Connect
This feasibility/pilot study has three purposes. First, the investigators will determine the feasibility of collecting saliva to measure stress biomarkers over three days at home in youth.
- Trial name
- NCT02970656
- Testing
- Teens.Connect
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Yale University
Atherosclerotic Cardiovascular Disease, Childhood Diabetes Mellitus
Atherosclerotic Cardiovascular Risk in Childhood and Teen-age Onset Diabetes
For children and adolescents with diabetes, the pathological process of atherosclerotic cardiovascular disease(ASCVD) can exist in early childhood and progress rapidly to subclinical ASCVD.
- Conditions
- Atherosclerotic Cardiovascular Disease, Childhood Diabetes Mellitus, Juvenile Diabetes
- Trial name
- NCT05294653
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type I Diabetes
Management of Type 1 Diabetes Among Adolescents
This 1-year study will explore the influences of family and peers on how diabetic adolescents manage their disease, focusing on adolescent developmental transitions.
- Trial name
- NCT00340639
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sleep Apnea, Obstructive, Type 1 Diabetes (T1D)
Type 1 Diabetes and Obstructive Sleep Apnea
The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes.
- Trial name
- T1D and OSA (NCT06915831)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Type 1 Diabetes Mellitus
Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
The purpose of this pilot study is to test the safety and feasibility of using two or three research modules in conjunction with an automated insulin delivery device (AID).
- Trial name
- NCT04784637
- Testing
- Web Simulation Tool (WST), Behavioral Adaptation Module (BAM), Auto Titration Module (ATM)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Diabetes
Safety and Efficacy of Single Administration of Oshadi Oral Insulin in Type I Diabetes Patients
The study will be a non-randomized, open label, single dose, single blind, placebo control, single center, single arm study in Type I diabetes patients.
- Trial name
- NCT01120912
- Testing
- Oshadi Oral Insulin
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Oshadi Drug Administration
Type 1 Diabetes
Treatment of Patients With Newly Onset of Type 1 Diabetes With Mesenchymal Stem Cells
The main hypothesis of the investigators study is that the development of autoimmune diabetes may be halted att diagnosis by the immune modulatory properties of mesenchymal stem cells.
- Trial name
- NCT01068951
- Testing
- Mesenchymal stem cells
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University Hospital
Type 1 Diabetes
Artificial Pancreas With Different Stress Assessments in the Outpatient Setting
This feasibility study is a randomized crossover trial that will compare the efficacy and safety of an automated insulin delivery (AID) system in patients with type 1 diabetes using a Model Predictive Control (MPC) algorithm…
- Trial name
- NCT04142229
- Testing
- iAPS, Sensor-Augmented Pump
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes, Diabetes Mellitus, Type 1
An Observational Study to Assess Safety and Effectiveness of Intravenous NovoRapid® in Hospitalised Subjects
This study is conducted in Asia. The aim of this observational study is to evaluate the side effects profile and benefits of using intravenous insulin aspart infusion in hospitalised subjects under normal clinical practice…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00700648
- Testing
- insulin aspart
- Where
- India
- Volunteers
- 3,024 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Positron Emission Tomography (PET) Imaging of Pancreatic Beta-Cell Mass in Healthy and Type 1 Diabetic Patients
Pancreatic Islet beta-cells are responsible for synthesizing and secreting appropriate amounts of insulin to regulate blood glucose levels. One factor in the development of diabetes is the loss of beta-cells.
- Trial name
- NCT00958997
- Testing
- 18F-FP-DTBZ (18F-AV-133), Arginine-hydrochloride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 1 Diabetes
Insulin Resistance in Type I Diabetes in Pediatric Care
24 children (12 African-American, Hispanic, or American Indian, 12 Caucasian) previously diagnosed with type 1 diabetes mellitus will participate in this pilot study to evaluate the presence of hepatic and peripheral insulin…
- Trial name
- NCT00946426
- Testing
- Clamp
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Type 1 Diabetes
A Study to Evaluate Pneumococcal Polysaccharide Vaccine Effectiveness in Children With Type 1 Diabetes
The purpose of this study is to determine if children with type 1 diabetes have adequate immune response to PPSV23 vaccination and to assess factors affecting immune response.
- Trial name
- NCT04481243
- Testing
- Pneumovax 23- pneumococcal polysaccharide, Blood draw
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Medtronic MiniMed Implantable Insulin Pump
This research is being done to find out whether subjects previously treated with the implantable insulin pump (IIP) therapy, and now taking insulin by injection, will benefit from re-implantation of IIP.
- Trial name
- NCT00298740
- Testing
- Aventis U-400 Insulin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 1
Diabetes AutoimmunitY Withdrawn in Established Patients (DAY)
The study is a prospective, randomized, double-blind, placebo-controlled, multicenter trial in subjects with established T1D.
- Trial name
- DAY (NCT03794960)
- Testing
- TOL-3021
- Sponsor
- Tolerion, Inc.
Diabetes Mellitus, Type 1
Postprandial Blood Glucose Control and Gastric Emptying in Type 1 Diabetes: Pathogenetic Factors and Therapeutic Options
This study evaluates the prevalence of gastric emptying (GE) in type 1 diabetic patients (DM1) free of chronic complications in comparison with a group of healthy control subjects.
- Trial name
- NCT02365740
- Testing
- gastric emptying test, gut hormones determination, Continuous Glucose Monitoring
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federico II University
Type 1 Diabetes Mellitus
HCL in Adults With T1DM, Markedly Elevated HbA1c, and Psychological Vulnerability
The objective of this study is to evaluate whether the mylife CamAPS FX hybrid closed loop (HCL) system improves glycemic control and quality of life in type 1 diabetes (T1DM) patients with a chronic lack of glycemic control and…
- Trial name
- Hi-Loop (NCT07509060)
- Testing
- mylife CamAPS FX hybrid closed-loop system
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Jerzy Hohendorff
Type 1 Diabetes
Imaging of Type 1 Diabetes Progression
Type 1 diabetes results from the autoimmune destruction of the insulin-producing beta cells of the islets of Langerhans of the pancreas.
- Trial name
- NCT01521520
- Testing
- ferumoxytol
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Jason Gaglia
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