Clinical trials: Juvenile-Onset Diabetes
Type 1 Diabetes
Overnight Closed Loop Study in U.S.
This is a multicenter feasibility study. Up to 85 subjects will be enrolled in the study. The goal of the study is to demonstrate that the Hybrid Closed Loop (HCL) System is safe to be used in an even larger study outside of…
- Trial name
- OCL (NCT01857973)
- Testing
- Hybrid Closed Loop
- Where
- 6 sites in United States
- Volunteers
- 78 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes (T1D)
Stretching and Diabetes
Diabetes mellitus is a persistent disease characterized by alterations in glucose metabolism due to insufficient insulin production or decreased sensitivity to insulin.
- Trial name
- STREDIB (NCT06774105)
- Testing
- Static Stretching
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- University of Palermo
Type 1 Diabetes
Use of Continuous Glucose Monitoring System With Intensive Feedback in Adolescents With Poorly Controlled Type 1 Diabetes
The purpose of this study is to determine that continuous glucose monitoring systems (CGMS) with intensive real time feedback about diabetes management from medical staff to the patient will affect motivation and/or behavior, in…
- Trial name
- NCT03020069
- Testing
- CGMS Device, No Device
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- NYU Langone Health
Type 1 Diabetes
The Summer Camp Study: Blood Glucose Control With a Bi-Hormonal Bionic Endocrine Pancreas
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers both insulin and glucagon can improved glycemic control vs.
- Trial name
- NCT01833988
- Testing
- Bi-hormonal Bionic Pancreas, Usual Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Mental Health Issue, Diabetes Distress
Examining the Feasibility of Wysa in Hindi
The principal objective of this study is to investigate the feasibility of including a digital mental health intervention (Wysa in Hindi) within pre-existing usual care to support adolescents and young adults with Type 1 Diabetes…
- Trial name
- NCT06320756
- Testing
- Wysa in Hindi, Individual and group sessions on topics like motivation, coping, wellbeing
- Where
- India
- Volunteers
- 79 people
- Sponsor
- Wysa
Type 1 Diabetes, Inflammation
Low Grade Inflammation in Type 1 Diabetes Children
The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.
- Trial name
- Coccinelle (NCT01099956)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Type 1 Diabetes Mellitus
Pizza-Salami Study in Children and Adolescents With Type 1 Diabetes
The Pizza-Salami-Study aims to investigate the efficacy of carbohydrate plus fat/protein (CFP) counting compared with carbohydrate (CARB) counting using normal and dual-wave bolus in sensor-augmented pump therapy in children and…
- Trial name
- NCT01400659
- Testing
- CFP counting, CARB counting
- Volunteers
- 42 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes, Physical Activity
Regular Physical Exercise Extends Honeymoon Phase in Type 1 Diabetes Subjects
In diabetes, the honeymoon period is characterized by the presence of a functional reserve of β-cells that favours an adequate metabolic control and low insulin needs in order to control glycaemia.
- Trial name
- Honeymoon (NCT01789190)
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- University Hospital A Coruña
Diabetes Mellitus, Type 1
Influence of Aerobic Exercise and HIIT on Glycemic Control in Adult Men With Type 1 Diabetes (TAILOR/1b)
Physical exercise is one of the main recommendations included in clinical guidelines for people with type 1 diabetes (T1D) because it is associated with substantially lower cardiovascular and overall mortality risks.
- Trial name
- TAILOR/1b (NCT06080542)
- Testing
- Aerobic, High-intensity interval training
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Valencia
Diabetes Mellitus, Type 1
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B
Glutathione is normally present at high levels in the blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by several reactive oxygen species produced by…
- Trial name
- NCT00858273
- Testing
- Antioxidant supplement, Diabetes treatment, Regular Insulin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes
Adapting FAMS to Optimize CGM Use Among Emerging Adults With Type 1 Diabetes
The goal of this clinical trial is to evaluate the efficacy of an adapted FAMS (Family/friend Activation to Motivate Self-care) intervention on CGM use among study participants who are CGM users.
- Trial name
- NCT05854069
- Testing
- FAMS-T1D, Digital resources for diabetes
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes, Hypoglycemia
Dipeptidyl Peptidase-4 Inhibitors and Alpha-cell Recovery
Hypoglycaemia is a well-known complication of insulin treated diabetes. The counterregulatory response to hypoglycaemia, with glucagon as the most important mediator, is initially diminished within a few years of onset of Type 1…
- Trial name
- DARE (NCT01272583)
- Testing
- Sitagliptin
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Type 1 Diabetes Mellitus With Diabetic Nephropathy
Effect of Dietary Protein Restriction on Prognosis in Patients With Diabetic Nephropathy
The purpose of the investigators study was to determine the effect of dietary protein restriction on survival and progression to end stage renal disease (ESRD) in diabetic nephropathy.
- Trial name
- LPD (NCT01521910)
- Testing
- low protein diet, normal protein diet
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
The main goal is to perform a cost-utility analysis to compare islet cell transplantation versus best medical treatment (defined as Sensor augmented pump therapy) for patients with brittle type1 diabetes.
- Trial name
- STABILOT (NCT02854696)
- Testing
- Islet graft, best medical care
- Where
- 11 sites in France, Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Insulin-Dependent Diabetes Mellitus 1
Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
This study is designed to evaluate the prevalence of different stages of diabetic retinopathy and diabetic macular edema among patients suffering from type 1 diabetes (DM 1) for 5 to 25 years and have been treated with…
- Trial name
- NCT02307110
- Testing
- cross-sectional observation
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Vista Klinik
Type 1 Diabetes (T1D)
Technology Knowledge Optimization for Type 1 Diabetes in Schools
The goal of this study is to evaluate the feasibility and acceptability of a school nurse focused e-Learning application to improve their diabetes device knowledge and confidence.
- Trial name
- TeKnO T1D (NCT07482488)
- Testing
- TeKnO T1D curriculum
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Pittsburgh
Treatment of Type I Diabetes Mellitus.
Dendritic Cells for Type 1 Diabetes Mellitus (T1DM) Therapy
Phase IB will evaluate the safety of autologous, ex vivo-engineered, co-stimulation impaired dendtritic cells to maintain and improve functional residual beta cell mass in new onset Type I Diabetes Mellitus (T1DM) patients.
- Trial name
- NCT01947569
- Testing
- Biological
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- DiaVacs, Inc.
Type1diabetes
Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children
To investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of…
- Trial name
- MAIT-DT1 (NCT05054361)
- Testing
- MAIT cells analysis, MAIT cytokines production analysis, Lactulose/Mannitol Test
- Where
- 2 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type 1 Diabetes Mellitus
A Phase 2 Two-Part Study of Oral PS1 in Healthy Volunteers and Adults With Newly Diagnosed Type 1 Diabetes
This study consists of 2 sub-studies, including Part A and Part B. Part A is intended to further characterize the pharmacokinetic (PK) profile of PS1 based on existing single ascending dose (SAD) and multiple ascending dose (MAD)…
- Trial name
- NCT07889505
- Testing
- PS1
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pharmasaga Co. Ltd.
Type 1 Diabetes
Ecological Momentary Assessment Study of Adolescents and Young Adults With Type 1 Diabetes (EMA-T1D)
This single site investigator-initiated prospective observational study will enroll up to 150 participants 13-26 years of age with Type 1 diabetes (T1D) and utilize ecological momentary assessment methods (EMA) to examine…
- Trial name
- NCT06129994
- Testing
- Observational
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Michigan
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