Clinical trials: Juvenile-Onset Diabetes
Diabetes Mellitus, Type 1
Evaluation of a Mobile Application to Optimize Self-decision on Metabolic Control in Persons With Type 1 Diabetes
Adolescents with type 1 diabetes mellitus (T1 DM) tend to have poor metabolic control. There are no mobile applications in our language in our environment, and patients are accessible in addition to the difficulties involved in…
- Trial name
- DM-BLUE (NCT05143411)
- Testing
- PRE-test
- Where
- Dominican Republic
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Iberoamericana
Type 1 Diabetes
Supporting Treatment Adherence Needs in Diabetes
There is an unmet treatment need for depressed adolescents with type 1 diabetes. To address this unmet need, we have designed a new, family-based, cognitive-behavioral intervention to reduce depressive symptoms, improve family…
- Trial name
- STAND (NCT01030471)
- Testing
- Family-based cognitive-behavioral treatment
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Non-Nutritive Sweetener, Type 1 Diabetes
Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D)
This project will apply a novel non-nutritive sweetener (NNS) dietary assessment tool with measurement of circulating NNS levels in a pediatric population, allowing correlation of NNS exposure to clinically meaningful…
- Conditions
- Non-Nutritive Sweetener, Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
- Trial name
- NCT07434544
- Testing
- Cherry Sports Drink
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Type 1 Diabetes, Hypoglycemia
Slow Digestible Carbohydrates and Exercise in Adolescents With Type 1 Diabetes
In this within-subject cross-over study, the investigators hypothesize that corn-starch based supplements taken prior to exercise will decrease the risk of delayed hypoglycemia in adolescents with T1D, improve performance during…
- Trial name
- NCT05540132
- Testing
- maltodextrin, super starch
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Type 1 Diabetes
Impact of Functional Insulinotherapy on Blood Glucose Variability Indicators in Patients With Type 1 Diabetes
The primary objective of this trial is to assess whether functional insulinotherapy decreases blood glucose variability at 3 months and 6 months, compared to initial values in type 1 diabetes patients.
- Trial name
- VARIAFIT (NCT00973492)
- Testing
- functional insulinotherapy class
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association Grenobloise pour le Developpement D'etudes et de Recherches en Physiopathologie Endocrinienne, Diabetologie et Maladies de la Nutrition
Type 1 Diabetes Mellitus
The Effects of Fluoxetine and/or DHEA
(1) To determine how the Selective Serotonin Reuptake Inhibitor (SSRI), fluoxetine (Prozac), an antidepressant often used to treat depression, stimulates the participant's body's ability to defend against low blood sugar…
- Trial name
- NCT03228732
- Testing
- Fluoxetine, DHEA, Fluoxetine and DHEA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Type 1 Diabetes
Impact of a Low-Carbohydrate Diet in Pediatric Type 1 Diabetes
Dietary carbohydrate consumption is a key factor influencing postprandial glycemia for patients with type 1 diabetes mellitus (T1DM).
- Trial name
- NCT03997409
- Testing
- Dietary Intervention
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Impact of Acetaminophen on Performance of Guardian™ Sensor (3) in Adults
The purpose of this study is to characterize the impact of acetaminophen ingestion on the performance of the Guardian™ Sensor (3) (i.e., C algorithm and Zeus algorithm) in subjects age 18 - 80 years.
- Trial name
- NCT04378114
- Testing
- Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. C sensor algorithm applied retrospectively to raw sensor data., Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. Zeus sensor algorithm applied retrospectively to raw sensor data., Acetominophen
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Continuous Subcutaneous Insulin Infusion of Faster-acting Insulin Aspart Compared to NovoRapid® in Adults With Type 1 Diabetes
This trial is conducted in Europe and the United States of America (USA). The aim of this trial is to investigate efficacy and safety of Continuous Subcutaneous Insulin Infusion of Faster-acting Insulin Aspart compared to…
- Trial name
- Onset® 5 (NCT02825251)
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- 92 sites in United States, Belgium and 7 more
- Volunteers
- 472 people
- Sponsor
- Novo Nordisk A/S
Tumor, Solid
Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors
This study will examine whether patients with relapsed/refractory solid tumors harboring evidence of somatic hypermutation (intermediate versus high tumor mutational burden) will exhibit improvement in disease progression-free…
- Trial name
- NCT03911557
- Testing
- Durvalumab and Tremelimumab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- John L. Villano, MD, PhD
Type 1 Diabetes
Tauroursodeoxycholic Acid (TUDCA) in New-Onset Type 1 Diabetes
Clinically, the ability to slow or prevent beta cell demise can prevent or improve the course of type 1 diabetes. The immune-mediated destruction of beta cells that is an apparent major pathological basis for the disease, has led…
- Trial name
- NCT02218619
- Testing
- Tauroursodeoxycholic Acid (TUDCA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Robin Goland, MD
Diabetes Mellitus, Type 1
Influence of Diabetic Neuropathy on Activation of Brown Adipose Tissue
Influence of diabetic neuropathy on cold induced brown adipose tissue in type 1 diabetic patients.
- Trial name
- DIA-BAT (NCT03695731)
- Testing
- cold induced activation of brown adipose tissue
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Doctor Giacomo Gastaldi
Congenital Heart Disease, Viremia
Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes
Beyond EV-B, there are clinical observations to implicate other viruses in birth defects, including CHD. Since the Rubella epidemic of 1960s', however, viruses have received little attention and certainly no comprehensive study…
- Conditions
- Congenital Heart Disease, Viremia, Virus Diseases, Enterovirus
- Trial name
- CHARMED (NCT04769167)
- Testing
- Stool and Blood Specimen Collection, Follow-up Medical Record Review
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Hypoglycemia, Diabetes Mellitus, Type 1
A Study of Nasal Glucagon in Participants With Type 1 Diabetes Mellitus
The purpose of this study is to compare a needle-free treatment of hypoglycemia with nasal glucagon (study drug) to a marketed glucagon administered by the intramuscular (IM) route, in participants with type 1 diabetes mellitus…
- Trial name
- NCT03339453
- Testing
- Nasal Glucagon, Intramuscular Glucagon
- Where
- 2 sites in Germany
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
Safety Study of Repeated Doses of Glucagon on Animal Starch in the Liver
The purpose of this study is to learn if giving multiple doses of a hormone called glucagon can cause a major decrease in liver glycogen (animal starch).
- Trial name
- NCT01986231
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Legacy Health System
Type 1 Diabetes Mellitus
Efficacy and Safety of Insulin Glargine Versus. Neutral Protamine Hagedorn (NPH) Insulin in Children With Type 1 Diabetes Above 6 Years Old.
Primary Objective: 6 To assess the efficacy of insulin glargine given once daily (QD) on glycosylated hemoglobin (HbA1c) levels over a period of 24 weeks in children with type 1 diabetes mellitus (T1DM) aged at least 6 years to…
- Trial name
- Lantus-P-CN (NCT01223131)
- Testing
- Insulin glargine (HOE901), NPH insulin
- Where
- 10 sites in China
- Volunteers
- 162 people
- Sponsor
- Sanofi
Type 1 Diabetes
Diabetes Distress, Psychological Well-being and Family Hardiness in Parents of Children and Adolescents With T1D
Parents have an important role in child's diabetes management. Many studies show that parental psychological stress and family dynamics are associated with parental diabetes-related distress and treatment outcomes among children…
- Trial name
- NCT02010528
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Diabetes, Type 1 Diabetes
Looping Whilst Restricting Carbohydrates
To investigate the efficacy, safety and utility of hybrid closed-loop glucose control during a low carbohydrate vs. iso-energetic balanced diet in individuals with type 1 diabetes.
- Trial name
- LINEAR (NCT03932630)
- Testing
- Low carbohydrate diet, balanced diet
- Where
- Switzerland
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atherosclerotic Cardiovascular Disease, Childhood Diabetes Mellitus
Atherosclerotic Cardiovascular Risk in Childhood and Teen-age Onset Diabetes
For children and adolescents with diabetes, the pathological process of atherosclerotic cardiovascular disease(ASCVD) can exist in early childhood and progress rapidly to subclinical ASCVD.
- Conditions
- Atherosclerotic Cardiovascular Disease, Childhood Diabetes Mellitus, Juvenile Diabetes
- Trial name
- NCT05294653
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 1 Diabetes (T1D), Nutrition Therapy
Meal Frequency and Glycemic Control in Individuals With Type 1 Diabetes
The goal of this clinical trial is to examine the effect of 3 versus 6 daily meals of isocaloric diets on glycemic control and variability in individuals with type 1 diabetes.
- Conditions
- Type 1 Diabetes (T1D), Nutrition Therapy, Glycemic Control for Diabetes Mellitus
- Trial name
- NCT06934707
- Testing
- Three meals a day, Six meals a day
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
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