Clinical trials: Juvenile-Onset Diabetes
Diabetes Mellitus, Type 1
A Study to Look at How Insulin NNC0471-0119 Works in the Body in People With Type 1 Diabetes When Injected by Insulin Pump
This study is looking at the effect and safety of 3 formulations of the new rapid-acting insulin analogue NNC0471-0119, for the treatment of type 1 diabetes when given by insulin pump.
- Trial name
- NCT05262595
- Testing
- NNC0471-0119 A, NNC0471-0119 B, NNC0471-0119 D
- Where
- Austria
- Volunteers
- 19 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Liver
Safety Study of Pioglitazone Compared To Glyburide on Liver Function
The purpose of this study is to determine the liver safety of pioglitazone, once daily (QD), versus glyburide taken with metformin and insulin.
- Trial name
- NCT00494312
- Testing
- Pioglitazone, Glyburide
- Volunteers
- 2,120 people
- Sponsor
- Takeda
Type 1 Diabetes
FAMS-T1D Self-Regulation and Social Support for T1D
The goal of this clinical trial is to evaluate how effective the FAMS-T1D intervention is for improving self-regulation (e.g., setting and meeting goals for type 1 diabetes) and social support for meeting those goals for young…
- Trial name
- FAMS-T1D (NCT05820477)
- Testing
- FAMS-T1D, Digital resources for diabetes
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Utah
Diabetes Mellitus, Type 1
ATG-GCSF in New Onset Type 1 Diabetes
This is a three-arm, 1:1:1 randomized, placebo controlled, double- blinded trial in which at least 28 subjects will receive active Anti-Thymocyte Globulin and Granulocyte colony-stimulating factor (ATG-GCSF), at least 28 subjects…
- Trial name
- ATG-GCSF (NCT02215200)
- Testing
- Anti-Thymocyte Globulin (ATG), Granulocyte colony stimulating factor (GCSF)
- Where
- 13 sites in United States
- Volunteers
- 89 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Metabolic Impact
INTEGRATED IMPACT ASSESSMENT a Telemedicine Program in the Care of Patients With Diabetes Mellitus Type 1 Intensive Treatment With Multiple Daily Injections.
Prospective study of 6 months of evolution in people with type 1 diabetes with insulin multidose (MDI) and HbA1c> 7%. Patients were evaluated clinical, metabolic and psychological baseline and at 6 months, with a telematic visit…
- Trial name
- NCT02784236
- Testing
- telemedicine
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Diabetes Mellitus, Type 1
Relation Between Anthropometric Measurements and Balance in Children With Type 1 Diabetes Relation Between Anthropometric Measurements and Balance in Children With Type 1 Diabetes
Type 1 diabetes mellitus is the most common chronic metabolic disorder in children. Diabetic children who take proper nutrition and good care attain normal growth status.
- Trial name
- NCT05575609
- Testing
- children with Diabetes Mellitus, Type 1
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Type1diabetes
Observational Study of the Use of DBLG1 System in Real Life
This study will be conducted on human subjects and is observational, prospective and uncontrolled, defined as a category 3 according to the Jardé Law (RIPH3). It is a national and multicentric study.
- Trial name
- SP12 (NCT04749693)
- Testing
- DBLG1 System
- Where
- 20 sites in France
- Volunteers
- 348 people
- Sponsor
- Diabeloop
Diabetes Mellitus, Type 1
National Institute of Diabetes and Digestive Kidney Diseases* Share Plus: Continuous Glucose Monitoring With Data Sharing in Older Adults With Type 1 Diabetes* and Their Care Partners to Improve Time in Range and Reduce Diabetes Distress.
The purpose of this study is to test the Share plus intervention aimed at improving the use of data sharing between people with diabetes and their care partners in order to maximize the benefits of continuous glucose monitoring.
- Trial name
- NIDDK T1D (NCT05937321)
- Testing
- Share plus intervention, Control group
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of Utah
Type 1 Diabetes Mellitus
Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
The purpose of this study is to determine whether treatment with multiple injections of GAD-Alum will preserve the body's own (endogenous) insulin production in patients who have been recently diagnosed with type 1 diabetes…
- Trial name
- TN08 (NCT00529399)
- Testing
- GAD-Alum, GAD-Alum and Aluminum hydroxide, Aluminum hydroxide
- Where
- 15 sites in United States, Canada
- Volunteers
- 145 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Effect of Change in T1DM Glycemic Control
Effect of Metformin in Children With Type 1 Diabetes
Cardiovascular disease is the leading cause of mortality in type 1 diabetes mellitus (T1DM). Vascular dysfunction is an early and critical event in the development of cardiovascular disease.
- Trial name
- NCT04879511
- Testing
- metformin, Basal/bolus insulin
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Treatment Use of Generex Oral-lyn™ in Patients With Diabetes
The objective of this Treatment IND protocol is to provide Generex Oral-lyn™ to patients with serious or life-threatening Type 1 or Type 2 diabetes mellitus, with no satisfactory alternative therapy available for treatment of…
- Trial name
- NCT00948493
- Testing
- Buccal insulin spray
- Sponsor
- Generex Biotechnology Corp.
Type 1 Diabetes Mellitus
Intervention Groups for Adolescents With Type 1 Diabetes Mellitus
The purpose of this study is to utilize a group therapy adjustment and coping program at the Children's Hospital of Wisconsin with patients who have Type 1 Diabetes Mellitus (T1DM) and their parents within a "typical" clinical…
- Trial name
- NCT00622271
- Testing
- Group Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital and Health System Foundation, Wisconsin
Type 1 Diabetes
Hybrid Closed-Loop Hotel Studies With Medtronic PID Controller
The primary objective of this study is to evaluate the safety and efficacy of the Medtronic hybrid closed-loop (HCL) system utilizing the proportional-integral-derivative algorithm with insulin feedback (PID-IFB) optimized to…
- Trial name
- NCT02280863
- Testing
- Medtronic Hybrid Closed-loop System - Android Platform, Medtronic Hybrid Closed-loop Integrated System
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 1 Diabetes Mellitus
Carb Counting vs. Simplified Qualitative Meal-Size Estimation
The goal of this study is to compare qualitative meal-size estimation to accurate carb counting in adolescents with Type One Diabetes using all available AID (Automated Insulin Delivery) systems.
- Trial name
- NCT06687434
- Testing
- accurate carb counting, Simplified qualitative meal size estimation
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
Novel mHealth Physical Activity Intervention for Youth With Type 1 Diabetes Mellitus
The goal of this longitudinal cohort study is to learn about a mHealth intervention in Type 1 Diabetes (T1D) The main question[s] it aims to answer are: Does the intervention increase the amount of text messages between the…
- Trial name
- NCT06018844
- Testing
- NUDGE
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes, Diabetes Mellitus, Type 1
Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes
The investigators are doing this study to see the effect of insulin degludec in pregnant women with type 1 diabetes, and if it is safe to use.
- Trial name
- EXPECT (NCT03377699)
- Testing
- Insulin degludec, Insulin Aspart, Insulin detemir
- Where
- 71 sites in Argentina, Australia and 13 more
- Volunteers
- 225 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Super-Bolus: Effects on Postprandial Glycemia After High Glycemic Index Meal
The aim of this study is to determine whether Super-Bolus is more effective in postprandial glycemic control than Normal-Bolus after the high glycemic index (H-GI) meal in children with type 1 diabetes (T1DM) treated with insulin…
- Trial name
- NCT04019821
- Testing
- Insulin Glulisine, Insulin Aspart, Insulin Lispro
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Medical University of Warsaw
Type 1 Diabetes Mellitus
Islet Cell Transplantation Alone and CD34+ Donor Bone Marrow Cell Infusion in Type 1 Diabetes Mellitus
SPECIFIC AIMS: To reverse hyperglycemia and insulin dependency in patients with Type 1 diabetes mellitus by islet cell transplantation.
- Trial name
- NCT00315614
- Testing
- Islet Transplantation and Bone Marrow
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Miami
Type 1 Diabetes Mellitus
Medtronic 670G Insulin Pump and the Impact on Glycemic Control, Quality of Life, and Compliance
Analyze the Medtronic 670g pump on glycemic control
- Trial name
- NCT04329871
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Metabolic Research Institute, Inc.
Diabetes Mellitus, Type 1
Steno Tech Explore: A Study of Insulin Pump Users With Type 1 Diabetes
The present study is part of an overarching study being conducted in Denmark at Steno Diabetes Center Copenhagen (SDCC) and Nordsjællands Hospital Hillerød (NOH), Steno Tech, that aims to develop and ultimately, in a randomized…
- Trial name
- NCT04311164
- Testing
- Questionnaire-based survey, No intervention given.
- Where
- 2 sites in Denmark
- Volunteers
- 770 people
- Sponsor
- Steno Diabetes Center Copenhagen
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