Clinical trials: Juvenile-Onset Diabetes
Hypoglycemia
Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes
The purpose of this study is to investigate how the brain responds to low blood glucose in non-diabetic individuals. The ultimate goal is to understand the brain substrates of hypoglycemia unawareness, a condition that can occur…
- Trial name
- NCT02866435
- Testing
- Insulin, Glucose, Potassium phosphate
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes
Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes
Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk in type 1 diabetes (T1D). Non-esterified fatty acid elevation is a significant contributor to IR in T1D and may be a target of…
- Trial name
- AcT1 (NCT01816165)
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type1diabetes, Childhood ALL
Hb A1C Pre and Post Confinement in Latin American Children With Type 1 Diabetes: Dulce Study Group
A multicenter retrospective observational study among children with type 1 diabetes will be performed. The Objective of this study will be to determine a) the association between the increase in Hba1c in children with type 1…
- Trial name
- NCT04640064
- Where
- Argentina
- Volunteers
- 500 people
- Sponsor
- Hospital General Puyo
Type 1 Diabetes
Hybrid Closed Loop System for Patients on Multiple Daily Insulin Injections
The objective of this study is to assess structured group education onboarding protocol of the 670 G Hybrid Closed Loop (HCL) systems in achieving glucose control of patients on Multiple Daily Insulin Injections (MDI).
- Trial name
- NCT04145804
- Testing
- Medtronic Minimed 670G insulin pump
- Where
- Qatar
- Volunteers
- 40 people
- Sponsor
- Hamad Medical Corporation
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4
Epinephrine is one of the important hormones in the defense of hypoglycemia. We will test the hypothesis that antecedent hypoglycemia will blunt the metabolic, neuroendocrine and cardiovascular effects of subsequent epinephrine…
- Trial name
- NCT00608816
- Testing
- epinephrine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes Mellitus, Type One, Diabetes Mellitus, Type I
Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes
This Phase II RCT using multi-dose Bacillus Calmette-Guérin (BCG) in adults with juvenile or childhood onset diabetes is based on prior clinical trials showing that even with advanced disease and little of no remaining pancreas…
- Conditions
- Diabetes Mellitus, Type One, Diabetes Mellitus, Type I, Autoimmune Diabetes, Covid19
- Trial name
- NCT02081326
- Testing
- Bacillus Calmette-Guérin, Saline injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes
Clinical Efectivity of Two Different Sensor-augmented Pumps With Low Predictive Suspension Function
Observational cross-sectional multicenter study about effectiveness of two different sensor augmented-pumps with low glucose predictive function in Type 1 Diabetes Mellitus (T1DM) adult patients in routine clinical practice.
- Trial name
- NCT04741685
- Testing
- TTSX2, MM640G
- Where
- 3 sites in Spain
- Volunteers
- 23 people
- Sponsor
- Castilla-La Mancha Health Service
Coronary Heart Disease, Stroke
Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes
To investigate long-term effects on cardiovascular mortality/morbidity and renal failure in type 1 diabetes patients former randomized to intensive insulin treatment
- Conditions
- Coronary Heart Disease, Stroke, Renal Failure
- Trial name
- SDIS (NCT02138006)
- Testing
- Intensive insulin treatment, Standard insulin treatment
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 1
Impact of Dietary Intervention Within an Interprofessional Cooperative Protocol for Prandial Insulin Dose Adjustment in People Living With Type 1 Diabetes
This retrospective multicenter cohort study aims to evaluate the effectiveness of an interprofessional cooperative protocol allowing dietitians to adjust prandial insulin-to-carbohydrate ratios in adults living with type 1…
- Trial name
- INSUDIETCOOP (NCT07846852)
- Testing
- Routine care data collection
- Where
- 2 sites in France
- Volunteers
- 163 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 1
Use of Real-time Continuous Glucose Monitoring System in Patients With Type 1 Diabetes Mellitus
The purpose of this study is to determine whether a real-time continuous glucose monitoring system is able to improve HbA1c in patients suffering from type 1 diabetes compared to conventional finger prick glucose measurements.
- Trial name
- NCT00824148
- Testing
- Guardian REAL-Time Continuous Glucose Monitoring System, Conventional self-monitoring of plasma glucose
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Norwegian University of Science and Technology
Type 1 Diabetes
Overcoming Barriers and Obstacles to Adopting Diabetes Devices (ONBOARD) Trial
This study is a comprehensive, multicomponent behavioral intervention package (ONBOARD; OvercomiNg Barriers \& Obstacles to Adopting Diabetes Devices).
- Trial name
- ONBOARD (NCT04672655)
- Testing
- ONBOARD
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Molly Tanenbaum
Diabetes Mellitus
Insulin Glargine Plus Insulin Glulisine Multiple Daily Injections (MDI) Versus Premix Insulin Treatment in Subjects With Diabetes Mellitus (Type 1 or Type 2)
The purpose of this study is to test for superiority in improvements from baseline in patient reported outcomes in subjects with type 1 or type 2 diabetes when treated with insulin glargine plus rapid acting insulin glulisine MDI…
- Trial name
- NCT00135941
- Testing
- insulin glargine, insulin glulisine
- Where
- United States
- Volunteers
- 582 people
- Sponsor
- Sanofi
Type 1 Diabetes
ENCRT-103-hPI: Evaluation of an Immune-protected ENCRT-103-hPI Containing Primary Human Islets in Adults With Type 1 Diabetes, With and Without Standard-of-care Portal Vein Islet Infusion.
This study will evaluate the safety and performance of ENCRT-103-hPI, which is a cargo of primary islets inside Encellin's ENC-103-CED.
- Trial name
- NCT07680673
- Testing
- ENCRT-103-hPI encompasses the ENC-103 device, which will be implanted once loaded with primary islet cargo.
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Encellin
Diabetes Mellitus
Pharmacokinetic and Pharmacodynamic Properties of BIOD-123 and BIOD-125 Compared to Humalog® in Subjects With Type 1 Diabetes Including Assessments of Injection Site Toleration
The primary objective is to assess the speed of absorption of BIOD-123 and BIOD-125 and compare them to Humalog.
- Trial name
- NCT01908894
- Testing
- BIOD-123, BIOD-125, Humalog
- Volunteers
- 12 people
- Sponsor
- Biodel
Type 1 Diabetes
Rule-Based Closed Loop System for Type 1 Diabetes Control
The aim of the study is to assess the efficacy and safety of a Rule-based Closed Loop system, using subcutaneous way, for the overnight and prandial glucose control in type 1 diabetic subjects.
- Trial name
- NCT01614496
- Testing
- Algorithm for insulin administration
- Where
- Spain
- Sponsor
- Corporacion Parc Tauli
Adult Subjects With Type1Diabetes and Insulin Microsecretion
Dulaglutide and Insulin MicrosecretiON in Type 1 Diabetes
Some patients with type 1 diabetes (T1D) can still have some remaining insulin-positive cells in the pancreas and secrete little amounts of insulin.
- Trial name
- DIAMOND GLP1 (NCT03668470)
- Testing
- Dulaglutide
- Where
- 7 sites in France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Type 1 Diabetes Mellitus Maturity Onset
Smartguard Use in Real Life : a Longitudinal Study in Patients With Type 1 Diabetes
The reference treatment of the type 1 diabetes is intensified insulin therapy by insulin pump. The CGM (continuous glucose monitoring) is a technology available for a decade, which allows the continuous measure of interstitial…
- Trial name
- Smartguard (NCT03047486)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Diabetes, Diabetes Mellitus, Type 1
A Non-interventional, Post Marketing Surveillance (PMS) Study of Tresiba® (Insulin Degludec) to Evaluate Long Term Safety and Efficacy in Patients With Diabetes Mellitus in Routine Clinical Practice in India
This study is conducted in Asia. The aim of the study is to evaluate long term safety and efficacy of Tresiba® (insulin degludec) in patients with diabetes mellitus in routine clinical practice in India.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02117622
- Testing
- insulin degludec
- Where
- 38 sites in India
- Volunteers
- 1,056 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Autoimmunity
Targeting GLUT1 to Control Autoimmunity in Type 1 Diabetes
Type 1 Diabetes is an autoimmune disease in which immune cells contribute to the destruction of insulin-producing pancreatic beta cells.
- Trial name
- GLUT1D (NCT07695727)
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus
Measurement Algorithm Control and Optimization With Subsequent Performance Evaluation of Sanmina Non-invasive Biosensors During a Standardized Meal Test in Patients With Diabetes Mellitus Type 1 and Type 2
Measurement algorithm control and optimization with subsequent performance evaluation of Sanmina biosensors in monitoring of glucose, heart rate (HR), and SpO2 in patients with type 1 and type 2 diabetes during a standardized…
- Trial name
- NCT04379427
- Testing
- Sanmina Biosensor
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sciema UG
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