Clinical trials: Keloid Scars
Keloid Scar
Keloid Scarring: Treatment and Pathophysiology
To clarify the mechanisms of Keloid scar formation. Elucidate the action and therapeutic value of 5-FU in Keloid scar treatment Identify the genetic link with Keloid scar formation.
- Trial name
- NCT01295099
- Testing
- 5- fluorouracil, radiotherapy, Triamcinolone
- Where
- United Kingdom
- Sponsor
- Queen Mary University of London
Acne Keloidalis Nuchae, NdYag Laser
NdYag Laser for Acne Keloidalis Nuchae
Acne Keloidalis Nuchae (AKN) is a long standing hair follicle disease with bumps and scars on the skin of the back of the head and neck.
- Conditions
- Acne Keloidalis Nuchae, NdYag Laser, AKN, Acne Keloidalis
- Trial name
- NCT00757315
- Testing
- NdYag Laser(hair removal laser) plus topical corticosteroid, Topical corticosteroid alone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Henry Ford Health System
Cesarean Section; Dehiscence, Scar Keloid
Patch With Onion Extract and Allantoin for C-section Scar
The wound healing is a process occurring in response to dermal injury. The resulting scar may have various characteristics ranging from fine-line and asymptomatic to hypertrophic scars and keloids.
- Conditions
- Cesarean Section; Dehiscence, Scar Keloid, Wound Heal
- Trial name
- NCT04046783
- Testing
- patch
- Where
- Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Salerno
Fibrosis
Study to Evaluate Fractional Collagen Synthesis Within Keloid Scars and Identify Biomarkers of Keloid Scars
This is a 3-arm randomised clinical enabling study, with no investigational product. Keloid patients who are scheduled for surgical excision of one or more keloid scars (up to nine) will be recruited to the study.
- Trial name
- NCT01978301
- Testing
- Triamcinolone acetonide
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- GlaxoSmithKline
Keloid
A Clinical Study on the Safety and Efficacy of Wide-Band Ultrasound Combined With Traditional Chinese Medicine Preparations in the Prevention and Treatment of Keloids
The prevention and treatment of patients with multiple keloids throughout the body are extremely challenging. Keloids are highly resistant, refractory, and prone to recurrence, and are thus known as the "cancer that does not…
- Trial name
- WBUS +TCM (NCT07679243)
- Testing
- Wide-Band Ultrasound, traditional Chinese medicine
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University Union Hospital
Hypertrophic or Keloid Scars
Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars
Hypertrophic or keloid scars develop for about 39% to 68% of patients after surgery. The subjective opinion of the patient regarding the scar will often constitute the standard for judging the success or failure of the procedure.
- Trial name
- NCT01861119
- Testing
- Silicone gel Kelo-cort™;, Onion extract gel Contractubex™
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- CHA University
Keloid
High Dose Rate Brachytherapy for Treatment of Keloids
This prospective study evaluates the outcome of surgical excision with adjuvant high-dose-rate brachytherapy for the treatment of recalcitrant keloids. Main outcomes are recurrence rate, scar quality and physical complaints.
- Trial name
- NCT02005055
- Testing
- Surgical excision with adjuvant high-dose-rate brachytherapy
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Amsterdam UMC, location VUmc
Keloid
A Pilot Study of Apligraf for the Treatment and Prevention of Recurrence of Excised Keloids
This pilot study will assess the safety and efficacy of Apligraf in the healing and recurrence of keloids post surgical shave excision in patients with clinically diagnosed keloids.
- Trial name
- NCT00587587
- Testing
- Apligraf, Standard dressing regimen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Organogenesis
Keloid
Transdermal Versus Intralesional Betamethasone for Keloids
This study aims to evaluate the efficacy and safety of transdermal delivery of compound betamethasone using a medium-frequency device compared with intralesional injection in the treatment of keloids.
- Trial name
- KBT (NCT07835438)
- Testing
- Compound betamethasone, Medium-frequency Therapeutic Device
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Hospital of China Medical University
Keloid
Analyse of Diagnosis Value of Keloid on 68Ga-RGD PET-CT
Keloids are often described as benign dermal fibroproliferative lesions characterized by increased growth beyond the boundaries of the original wound margin.Fibroblasts are considered to be the key cellular mediators of…
- Trial name
- NCT07660406
- Testing
- 68Ga-RGD
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Wound Heal, Scar
Pilot Study Investigating a Restorative Wound Care Cream Together With Petrolatum on Surgical Excisions
The pilot study is prospective, randomized, double-blinded, with intra-subject comparisons against a vehicle control. The primary objective of this pilot study is to investigate the safety and effectiveness of a new wound care…
- Conditions
- Wound Heal, Scar, Keloid, Surgical Wound
- Trial name
- NCT04169438
- Testing
- Vehicle Cream Base Emulsion Moisturizer + Petrolatum, FS2 Emulsion Moisturizer + Petrolatum
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Center for Clinical and Cosmetic Research
Skin Scarring
Early Carbon Dioxide Laser Therapy for Alleviation of Incisional Scar Burden
This is a prospective, randomized pilot study of patients who will undergo either early or late incisional laser therapy after breast reduction surgery to alleviate scar burden at NYU Langone Medical Center.
- Trial name
- NCT03306628
- Testing
- CO2 Laser Administration
- Where
- United States
- Sponsor
- NYU Langone Health
Keloid
Bleomycin Jet Injections in Keloids
This is a single center, double-blind (patient and investigator), randomized, placebo-controlled study with a split-lesion design, in which selected keloids will receive three consecutive treatments of a) bleomycin and b) placebo…
- Trial name
- NCT04582305
- Testing
- Bleomycin, Normal saline
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Erasmus Medical Center
Keloid
Fractional Laser Assisted Steroid Therapy vs Intralesional Steroids in the Treatment of Keloids
The purpose of this study is to compare the effects of fractional carbon dioxide (CO2) laser therapy immediately followed by intralesional steroid therapy against intralesional steroid therapy alone for the treatment of keloids.
- Trial name
- NCT02996097
- Testing
- The Lutronic electronic carbon dioxide (eCO2) Plus laser system, Intralesional Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Scar, Surgical Scar
Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars
The purpose of this study is to evaluate the safety and efficacy of the 532nm potassium titanyl phosphate (KTP) laser in comparison with the 595nm pulsed-dye laser (PDL) for the treatment of fresh surgical scars.
- Conditions
- Scar, Surgical Scar, Cicatrix, Cicatrix, Hypertrophic
- Trial name
- NCT01789346
- Testing
- 532nm KTP, 595nm PDL
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cutera Inc.
Keloid, Hypertrophic Scar
A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars
Keloids are thought to result from derailments in the typical wound healing process following cutaneous injury. Current treatment options for keloids include intralesional corticosteroids, silicone gel sheeting, compression…
- Conditions
- Keloid, Hypertrophic Scar, Cicatrix, Hypertrophic
- Trial name
- NCT00754247
- Testing
- 0.5% hydrocortisone, silicone, vitamin E lotion, Onion extract gel, Cetearyl alcohol lotion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Keloids, Hypertrophic Scars
Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars
Keloids and hypertrophic scars are a common subject of dermatologic consultations. Therapeutic management of such conditions remains challenging because of their high rate of recurrence and lack of curative treatment.
- Trial name
- NCT01078428
- Testing
- Topical silicone gel, Vaseline
- Where
- Thailand
- Volunteers
- 38 people
- Sponsor
- Mahidol University
Keloid, Scar
Safety and Efficacy of AIV001 on Scar Formation and Keloid Recurrence Following Keloidectomy
To evaluate the saftye and effectiveness of AIV001 treatment on scar formation and/or keloid scar recurrence following keloidectomy.
- Conditions
- Keloid, Scar, Incision, Excision Margin
- Trial name
- NCT04827875
- Testing
- AIV001
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- AiViva BioPharma, Inc.
Keloid, Cicatrix
Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars
This prospective evaluation studies the effectiveness of Intralesional (IL) cryotherapy with a argon gas based device in treating keloids and hypertrophic scars in population consisting of all Fitzpatrick skin type patients
- Conditions
- Keloid, Cicatrix, Hypertrophic
- Trial name
- NCT02063243
- Testing
- Intralesional cryotherapy
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Amsterdam UMC, location VUmc
Keloid
Efficacy and Safety of Fractional CO2 Laser Combined With Intralesional Insulin, Botulinum Toxin or Triamcinolone Acetonide in the Treatment of Keloid: A Clinical, Dermoscopic and Immunohistochemical Study.
Keloids are macroscopic cutaneous scarring that result from disturbance of wound healing, that occurs on predisposed individuals .
- Trial name
- NCT06230146
- Testing
- Insulin group, Botulinum toxin group, Triamcinolone acetonide group
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University