Clinical trials: Keratitis Bacterial
Corneal Ulcer, Fusarium Infection
Fusarium Keratitits in Spain 2012 to 2014
The aim of this study was to describe the clinical-epidemiological characteristics of a series of cases of fungal keratitis associated with Fusarium spp., In Spain during the years 2012 to 2014.
- Trial name
- NCT02984904
- Testing
- survey
- Volunteers
- 23 people
- Sponsor
- Miguel Armando Mosquera Gordillo, MD
Keratitis Bacterial, Keratitis Fungal
Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment
As conventional corneal scraping with bacterial culturing has several disadvantages such as long duration until diagnosis, invasiveness and lacks alternatives, there is demand for a novel non-invasive, rapid test in keratitis…
- Trial name
- VICTORIA (NCT05620264)
- Testing
- Tear Sample Probe
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Johannes Kepler University of Linz
Keratitis, Automatic Judgement
Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study
Detecting the cause of keratitis fast is the premise of providing targeted therapy for reducing vision loss and preventing severe complications.
- Conditions
- Keratitis, Automatic Judgement, Image
- Trial name
- NCT05538793
- Where
- 2 sites in China
- Volunteers
- 10,369 people
- Sponsor
- Ningbo Eye Hospital
Keratitis; Infectious Disease (Manifestation)
Pseudomonal Type Three Secretion System and Contact Lens Associated Microbial Keratitis
Microbial infection of the cornea, also known as microbial keratitis, causes severe corneal inflammation that could result in permanent visual loss.
- Trial name
- NCT01925846
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Infectious Keratitis, Bacterial Keratitis
Collagen Cross-linking in Infectious Keratitis Trial
The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.
- Conditions
- Infectious Keratitis, Bacterial Keratitis, Fungal Keratitis
- Trial name
- NCT01831206
- Testing
- Collagen cross-linking
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Infected Corneal Ulcers, Bacterial Keratitis
A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
Bacterial corneal ulcers are a leading cause of pediatric blindness in underdeveloped countries due to a lack of antibiotic availability and affordability, among other reasons.
- Conditions
- Infected Corneal Ulcers, Bacterial Keratitis, Corneal Ulcer, Childhood Blindness
- Trial name
- NCT00386958
- Testing
- Povidone-Iodine
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Bacterial Keratitis
Besifloxacin in Bacterial Keratitis
This is a study comparing a new treatment for bacterial keratitis (also known as corneal ulcers) with the current standard of care.
- Trial name
- NCT02497365
- Testing
- Besifloxacin, Tobramycin and Cefazolin
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Bacterial Keratitis, Antibiotic-resistant Bacteria
Novel Antisense Oligonucleotide Eye Drops for Treating Antibiotic-Resistant Bacterial Keratitis
The purpose of this study is to evaluate the safety and efficacy of GP-asPNA for in vivo treatment of severe antibiotic resistant bacterial keratitis.
- Conditions
- Bacterial Keratitis, Antibiotic-resistant Bacteria, Infections, Bacterial, Corneal Diseases
- Trial name
- ASOTARI (NCT06451172)
- Testing
- ASO
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Bacterial Keratitis
Matrix Therapy And Bacterial Keratitis
The purpose of this study is to evaluate efficiency of CACICOL20 for bacterial keratitis. It is a double blinded comparison of epithelial defect in two groups of patients randomized between CACICOL20 and physiological salt…
- Trial name
- CACICOL (NCT02016989)
- Testing
- RGTA OTR4120 (CACICOL20), physiological salt solution
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infective Keratitis
Microbial Keratitis in Cairo University Hospitals
The aim of the study was to identify the incidence of infective keratitis presenting to the ophthalmology emergency department at Cairo University hospital, the risk factors and the bacterial/fungal spectrum causing the ulcers…
- Trial name
- NCT05387993
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Kasr El Aini Hospital
Keratitis Bacterial
Steroids and Cross-linking for Ulcer Treatment
Steroids and Cross-linking for Ulcer Treatment (SCUT II) is an international, randomized, double-masked, clinical trial. The purpose of this study is to determine differences in 6-month visual acuity between medical antimicrobial…
- Trial name
- SCUT II (NCT04097730)
- Testing
- Moxifloxacin Ophthalmic, Difluprednate Ophthalmic, Riboflavin Ophthalmic
- Where
- 3 sites in United States, India
- Volunteers
- 280 people
- Sponsor
- Thomas M. Lietman
Dry Eye Syndrome, Infectious Keratoconjunctivitis
Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface
This study aims to obtain the lacrimal fingerprint for frequent pathologies of the ocular surface and establish a normative base for each of them.
- Conditions
- Dry Eye Syndrome, Infectious Keratoconjunctivitis, Mucous Membrane Pemphigoid, Allergic Conjunctivitis
- Trial name
- EML-MSO (NCT04198740)
- Testing
- Tear sample collection via Schirmer strip and subsequent analysis by mass spectrometry
- Where
- 2 sites in Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Corneal Ulcer, Eye Infections, Fungal
Mycotic Ulcer Treatment Trial I
The purpose of this study is to determine if natamycin or voriconazole results in better visual outcomes in fungal corneal ulcers, especially visual acuity.
- Trial name
- MUTT I (NCT00996736)
- Testing
- Natamycin, Voriconazole
- Where
- 3 sites in United States, India
- Volunteers
- 323 people
- Sponsor
- University of California, San Francisco
Keratoconus, Unstable, Bacterial Keratitis
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking
To determine whether the Peschke PXL-330 system is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
- Trial name
- NCT03918408
- Testing
- PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Pacific Clear Vision Institute
Infection, Fungal
Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis
OBJECTIVE To evaluate the efficacy and safety of the concurrent treatment of 5% Natamycin and 1% Voriconazole in patients affected by fungal keratitis METHODS AND MATERIALS STUDY POPULATION Patients with smear and or culture…
- Trial name
- NATA_VORI (NCT03230058)
- Testing
- Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
- Where
- India
- Volunteers
- 55 people
- Sponsor
- L.V. Prasad Eye Institute
Corneal Ulcer, Eye Infections, Bacterial
Steroids for Corneal Ulcers Trial
The purpose of this study is to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers, especially visual acuity.
- Trial name
- SCUT (NCT00324168)
- Testing
- Antibiotics, Topical corticosteroid
- Where
- 5 sites in United States, India
- Volunteers
- 500 people
- Sponsor
- Thomas M. Lietman
Corneal Ulcer
Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells
The goal of this study is to investigate the overall theory that the use of chemically preserved solutions associated with contact lenses promotes an increase in bacterial infection.
- Trial name
- NCT01104961
- Testing
- Contact lens packaging solution, Balanced salt solution (BSS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center