Clinical trials: Keratoconus
Down Syndrome (DS), Keratoconus
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07135167
- Testing
- Epi-ON corneal cross-linking (CXL)
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Woolfson Eye Institute
Keratoconus
Accelerated Corneal Cross-linking With Different Riboflavin Solutions
Following the Bunsen-Roscoe law, accelerated cross-linking protocols with higher irradiation intensities and shorter irradiation times have been introduced.
- Trial name
- NCT03187912
- Testing
- Riboflavin
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Glaucoma, Glaucoma, Open Angle
Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.
The purpose of this study is to evaluate the relationship between intraocular pressure and central corneal thickness using various instruments in ocular hypertension, normal-tension glaucoma, primary open angle glaucoma…
- Conditions
- Glaucoma, Glaucoma, Open Angle, Ocular Hypertension, Keratoconus
- Trial name
- NCT00347191
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Aston University
Corneal Ectasia
Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus
comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking
- Trial name
- NCT05691335
- Testing
- Standard CXL, Accelerated CXL, Transepithelial CXL
- Where
- Egypt
- Volunteers
- 97 people
- Sponsor
- Sohag University
Cornea, Eye Diseases
Intraestromal Corneal Ring in Mild Keratoconus
To determine whether the implantation of an intrastromal corneal ring is an effective treatment for a homogeneous group of mild keratoconus patients.
- Conditions
- Cornea, Eye Diseases, Keratoconus, Ophthalmological Disorder
- Trial name
- NCT03127163
- Testing
- Intraestromal corneal ring
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- University of Sao Paulo
Keratoconus
The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study
To describe the clinical course of keratoconus and to describe the relationships among its visual and physiological manifestations, including high- and low-contrast visual acuity, corneal curvature, slit lamp biomicroscopic…
- Trial name
- NCT00000155
- Where
- 14 sites in United States
- Sponsor
- National Eye Institute (NEI)
Keratoconus
Pentacam Findings After Implantation of Intrastromal Corneal Rings in Keratoconus.
keratoconus is a progressive corneal ectatic disease characterized by paraxial stromal thinning and weakening, resulting in irregular astigmatism, corneal protrusion, and distortion of the anterior corneal surface.
- Trial name
- NCT04562064
- Testing
- corneal tomography scans
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Assiut University
Keratoconus, Cornea
Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography
Investigators' research is concerned observing the post-operative anterior segment OCT changes throughout the post- operative follow up of the patient and relating to improve the visual outcome of the surgery which is the goal of…
- Conditions
- Keratoconus, Cornea, Corneal Opacity
- Trial name
- NCT05345652
- Testing
- deep anterior lamellar keratoplasty
- Volunteers
- 20 people
- Sponsor
- Assiut University
Keratoconus
KERatoconus and Metalloproteinases InvesTigation
Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix…
- Trial name
- KERMIT (NCT02891655)
- Testing
- immuno-histo-chemical analysis
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Keratoconus, High Myopia
Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug Imaging
The purpose of this study was to compare Scheimpflug corneal tomography findings in keratoconus and high myopic astigmatic eyes, as well as to establish the parameters distinguishing keratoconus from high myopic astigmatism.
- Trial name
- NCT06739018
- Testing
- pentacam scheimpflug tomography
- Where
- 2 sites in Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Keratoconus
Prevelance of Keratoconus
Keratoconus is a degenerative disease entity characterized by conical shape ectasia of the cornea. progressive conical deformation of the cornea leads to substantial astigmatism.
- Trial name
- NCT04092426
- Testing
- opthalmologic examination
- Volunteers
- 300 people
- Sponsor
- Assiut University
Keratoconus
Femtosecond Laser Assisted Keratoplasty
Penetrating keratoplasty (PKP) is corneal transplantation performed by using round trephine blades to create matched circumferential incisions in both the diseased cornea and the donor cornea.
- Trial name
- FLAK (NCT00802776)
- Testing
- Femtosecond laser assisted keratoplasty, PKP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Corneal Topography, Dry Eye Syndromes
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
The OCUTOP is a new hand-held camera that photographs the front of the eye to map the shape of the cornea and to assess the tear film.
- Conditions
- Corneal Topography, Dry Eye Syndromes, Keratoconus, Healthy Volunteers
- Trial name
- OCUTOP (NCT07895849)
- Testing
- OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment)
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Keratoconus, Glaucoma
Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus
The mechanism by which vision loss in glaucoma occurs is still unknown, but it is clear that increased Intraocular Pressure (IOP) is a major risk factor.
- Trial name
- NCT03560609
- Testing
- Ophthalmodynamometer, Goldmann applanation tonometer, Pentacam
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NYU Langone Health
Keratoconus in One or Two Eyes for Case, Good Visual Acuity for Control
Influence of Keratoconus on Stress at Work
Keratoconus is a progressive disorder in which central and paracentral corneal stromal thinning occurs. No studies evaluated the influence of keratoconus on stress at work, nor the influence of treatments of keratoconus on stress…
- Trial name
- KERATOSTRESS (NCT04789707)
- Testing
- auto-questionnaire
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Corneal Ectasia
Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia
This is a hospital-based interventional prospective study. Patients with clinical keratoconus or LASIK keratectasia presenting to the Singapore National Eye Centre who meet the eligibility criteria are recruited for this study.
- Trial name
- NCT01123057
- Testing
- riboflavin-induced collagen cross-linking treatment, Riboflavin-UVA induced collagen cross-linking treatment for corneal ectasia
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Keratoconus
Refractive Treatment of Early Keratoconus
Keratoconus is a bilateral, progressive corneal degenerative disorder that often leads to significant visual deterioration over time.
- Trial name
- NCT02613780
- Testing
- Crosslinking, Photorefractive keratectomy, iDesign® Advanced WaveScan Studio
- Volunteers
- 24 people
- Sponsor
- Ottawa Hospital Research Institute
Keratoconus, Astigmatism
Corneal Epithelial and Stromal Thickness Distribution in Keratoconus
The purpose of the study was to identify corneal epithelial- and stromal-thickness distribution patterns in keratoconic eyes using spectral-domain-optical coherence tomography (SD-OCT).
- Trial name
- NCT02023619
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- SynsLaser Kirurgi AS
Accommodation Disorder, Keratoconus
Clinical Investigation for a Multifunction Ophthalmic Measurement Device
The purpose of this clinical investigation is to evaluate the clinical utility of a multifunctional measuring device for Ophtalmology.
- Conditions
- Accommodation Disorder, Keratoconus, Dry Eye, Refractive Errors
- Trial name
- NCT06565091
- Testing
- Measurements of physiological parameters of the anterior chamber, Measurements of the Axial biometry
- Where
- France
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Essilor International