Clinical trials: Keratosis
Actinic Keratosis
Efficacy and Safety Phase II Study of SR-T100 to Treat Actinic Keratosis
This Phase II study is to evaluate the efficacy of SR-T100 gel with 2.3% of SM in Solanum undatum plant extract in patient with Actinic Keratosis (AK).
- Trial name
- NCT01516515
- Testing
- Vehicle gel, SR-T100 with 2.3% of SM
- Where
- 8 sites in United States
- Volunteers
- 86 people
- Sponsor
- G&E Herbal Biotechnology Co., LTD
Actinic Keratosis
Controlled Study of the Occurrence of Actinic Keratosis on the Face After Cryotherapy + Aminolevulinic Acid (ALA) Photodynamic Therapy
The purpose of this study is to determine if Levulan photodynamic therapy (PDT) is safe and effective in the treatment of actinic keratoses (AK) on the face, following treatment with liquid nitrogen cryotherapy.
- Trial name
- NCT02239679
- Testing
- Aminolevulinic Acid, Topical Solution Vehicle, BLU-U
- Where
- 8 sites in United States
- Volunteers
- 166 people
- Sponsor
- DUSA Pharmaceuticals, Inc.
Actinic Keratosis
Ph 1, Single-Center, Safety, Tolerability & Pharmacokinetic Study of KX2 391 Ointment in Subj. w Actinic Keratosis
This is a phase 1 study to access the safety and tolerability of KX2-391 ointment in subjects who have Actinic Keratosis. This study will also access the amount of KX2-391 drug that enters the blood stream through dermal…
- Trial name
- NCT02337205
- Testing
- KX2-391 Ointment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Athenex, Inc.
Seborrheic Keratosis
An Open-Label Safety Study of A-101 Solution
This is an open-label safety study. During this study, the investigator will identify 4 eligible SK Target Lesions on each subject on the trunk, extremities and face.
- Trial name
- NCT02667288
- Testing
- A-101 Solution
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Aclaris Therapeutics, Inc.
Seborrheic Keratosis
A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis.
This is a randomized, double-blind, vehicle-controlled, parallel group study of A-101 Solution 40% compared with Vehicle Solution.
- Trial name
- NCT02667236
- Testing
- A-101 Solution, Vehicle Solution
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Aclaris Therapeutics, Inc.
Seborrheic Keratosis
A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis
This is a randomized, double-blind, vehicle-controlled, parallel group study.
- Trial name
- SK (NCT02667275)
- Testing
- A-101 Solution, Vehicle Solution
- Where
- United States
- Volunteers
- 487 people
- Sponsor
- Aclaris Therapeutics, Inc.
Actinic Keratosis
Microneedle Lesion Preparation Prior to Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) for AK on Face
The purpose of this study is to determine the viability of microneedle lesion preparation (MN) to enhance treatment benefit when performed prior to ALA PDT to an actinic keratosis (AK) field on the face.
- Trial name
- NCT02632110
- Testing
- ALA, Topical Solution Vehicle, IBL 10 mW
- Where
- 8 sites in United States
- Volunteers
- 137 people
- Sponsor
- DUSA Pharmaceuticals, Inc.
Actinic Keratosis
Phase 3 Study of Levulan With New Blue Light for AK on the Face or Scalp
The purpose of this study is to prove the safety and efficacy of Levulan Kerastick (aminolevulinic acid HCl) for Topical Solution 20% followed by 10 J/cm2 of blue light delivered at 10 mW/cm2 or 20 mW/cm2 in the treatment of…
- Trial name
- NCT03024060
- Testing
- ALA, Vehicle, IBL 20 mW
- Where
- 7 sites in United States
- Sponsor
- DUSA Pharmaceuticals, Inc.
Keratosis, Actinic
Maximal Use Systemic Exposure Study of Levulan Kerastick (MUSE 2)
The purpose of this study is to evaluate the potential for systemic exposure of aminolevulinic acid (ALA) and protoporphyrin IX (PpIX) when applied topically under occlusion, in a maximal use setting in patients with multiple…
- Trial name
- NCT02628236
- Testing
- Aminolevulinic Acid (ALA), BLU-U
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- DUSA Pharmaceuticals, Inc.
Keratosis Pilaris
Cosmetic Study of AO+Mist in Improving the Appearance of Skin Afflicted With Keratosis Pilaris
The purpose of this study is to demonstrate the safety, tolerability and efficacy of AO+ Mist administered daily for 4 weeks to improve the appearance of skin afflicted with keratosis pilaris.
- Trial name
- NCT03243617
- Testing
- AO+Mist
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- AOBiome LLC
Actinic Keratosis
A Randomized, Double-Blind, Parallel-Group, Vehicle-Controlled, Multicenter Study Comparing Diclofenac Sodium Gel, 3% to Solaraze® Gel, 3% in the Treatment of Actinic Keratosis on the Face or Bald Scalp
To compare the efficacy and safety profiles of Teva's Diclofenac Sodium Gel, 5% (test product) to Solaraze® (diclofenac sodium) Gel, 3% (reference product) to demonstrate the clinical equivalence and to show that the efficacy of…
- Trial name
- NCT02611804
- Testing
- Diclofenac sodium
- Where
- 30 sites in United States
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Actinic Keratosis
Evaluation of Safety and Efficacy of BF-200 ALA for the Treatment of Actinic Keratosis With Photodynamic Therapy
The aim of the study is to evaluate the non-inferiority of BF-200 ALA (Ameluz) in the treatment of actinic keratosis (AK) with photodynamic therapy (PDT) compared to Metvix.
- Trial name
- NCT02799069
- Testing
- BF-200 ALA, MAL Cream, Vehicle
- Volunteers
- 571 people
- Sponsor
- Biofrontera Bioscience GmbH
Actinic Keratosis
Evaluation of Efficacy and Safety of BF-200 ALA Used With Photodynamic Therapy in Patients With Actinic Keratosis.
The aim of the study was to evaluate the efficacy and safety of BF-200 ALA (Ameluz) used with photodynamic therapy (PDT) in patients suffering from actinic keratosis.
- Trial name
- NCT02799082
- Testing
- Vehicle, BF-200 ALA
- Volunteers
- 122 people
- Sponsor
- Biofrontera Bioscience GmbH
Keratosis, Actinic
Maximal Use Systemic Exposure (MUSE) Study of Levulan Kerastick
The purpose of this study is to evaluate the potential for systemic exposure of aminolevulinic acid (ALA) when applied topically under occlusion, in a maximal use setting in patients with multiple actinic keratoses (AK) involving…
- Trial name
- NCT02281136
- Testing
- Aminolevulinic Acid (ALA), BLU-U
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- DUSA Pharmaceuticals, Inc.
Actinic Keratosis
Short-incubation Levulan Photodynamic Therapy Versus Vehicle for Face/Scalp Actinic Keratosis (AK)
The purpose of this study is to determine if Levulan Photodynamic Therapy (PDT) is safe and effective in the treatment of actinic keratosis when applied to broad areas on the face and scalp for 1, 2 and 3 hours.
- Trial name
- NCT01475955
- Testing
- Broad Area ALA 1-hour incubation, Broad Area ALA 2 hour incubation, broad area ALA 3-hour incubation
- Where
- 13 sites in United States
- Volunteers
- 235 people
- Sponsor
- DUSA Pharmaceuticals, Inc.
Actinic Keratosis
Photodynamic Therapy of Actinic Keratoses With Alacare®
This study aims to collect data on the frequency of SCCs in the Alacare®-treated area during an interval of two years after Alacare®-PDT.
- Trial name
- NCT01571336
- Where
- 8 sites in Germany
- Volunteers
- 388 people
- Sponsor
- photonamic GmbH & Co. KG
Actinic Keratosis
Twelve Month Follow-Up of CP0108
The purpose of this study is to determine the long-term safety and efficacy of Levulan PDT in subjects with multiple actinic keratosis of the upper extremities who received treatment as part of the DUSA CP0108 study.
- Trial name
- NCT02209012
- Testing
- Aminolevulinic Acid (ALA), Topical Solution Vehicle, BLU-U Blue Light Photodynamic Therapy Illuminator
- Where
- 13 sites in United States
- Volunteers
- 206 people
- Sponsor
- DUSA Pharmaceuticals, Inc.
Actinic Keratosis
Study To Evaluate The Efficacy And Safety Of Actikerall® Solution In Patients With Grade I-II Actinic Keratoses
The main purpose of this vehicle-controlled study is to determine the efficacy and safety of a solution of Actikerall® (containing 5-fluorouracil 0.5% and salicylic acid 10.0%) in the field-directed treatment of grade I-II…
- Trial name
- NCT02289768
- Testing
- 5-fluorouracil/salicylic acid, Vehicle
- Where
- 14 sites in Germany, United Kingdom
- Volunteers
- 166 people
- Sponsor
- Almirall, S.A.
Actinic Keratosis
Observational Trial Tolerability and Efficacy of Resiquimod Gel in Patients Treated for Actinic Keratosis.
Determine the recurrence rate of actinic keratosis (AK) lesions in patients with complete clinical clearance at the end of the previous trial SP848-AK-1101 at 6 and 12 months of follow-up.
- Trial name
- NCT01806961
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 16 people
- Sponsor
- Spirig Pharma Ltd.
Actinic Keratosis
A Clinical Trial of Topical Photodynamic Therapy With 5-aminolevulinic Acid for the Treatment of Actinic Keratosis
This was a placebo controlled, double blind, randomized phase II dose-response study to evaluate the efficacy and safety of BF-200 ALA (containing the active ingredient 5 - aminolevulinic acid- ALA) used with photodynamic therapy…
- Trial name
- NCT02799030
- Testing
- BF-200 ALA 1%, BF-200 ALA 3%, BF-200 ALA 10%
- Volunteers
- 105 people
- Sponsor
- Biofrontera Bioscience GmbH