Clinical trials: Keratosis
Actinic Keratoses
Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic Keratosis
The goal of this clinical trial is to compare the effectiveness and safety of two treatments-cryotherapy and 5-Fluorouracil (5-FU)-for actinic keratosis, a common skin condition caused by long-term sun exposure.
- Trial name
- NCT06461442
- Testing
- Cryotherapy, 5Fluorouracil
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of California, Davis
Actinic Keratoses
Effects of Topical Diclofenac on Tumor Metabolism
The rationale of this study is to investigate the effects of topical diclofenac on tumor metabolism in the treatment of actinic keratoses in immunocompetent and immunocompromised patients.
- Trial name
- NCT01935531
- Testing
- 3% diclofenac in 2.5% hyaluronic acid gel
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- University Hospital Regensburg
Disorder of Middle Ear, Otosclerosis of Middle Ear
Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively
Feasibility of the objective measurement of the ossicular chain mobility, by using a force-measuring device based on a fiber optics sensors (PalpEar).
- Conditions
- Disorder of Middle Ear, Otosclerosis of Middle Ear, Cholesteatoma, Middle Ear
- Trial name
- PalpEar (NCT02554422)
- Testing
- PalpEar
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sensoptic SA
Actinic Keratosis
Study to Determine the Safety of PEP005 0.025% and 0.05% Topical Gel in Patients With Actinic Keratoses
The purpose of this study is to determine whether topical application of PEP005 is safe for the treatment of actinic keratoses.
- Trial name
- NCT00375739
- Testing
- PEP005
- Where
- 24 sites in United States
- Volunteers
- 200 people
- Sponsor
- Peplin
Actinic Keratosis (AK)
Outcomes Associated With Tirbanibulin for Large Field Application on the Face in the U.S (CLEAR)
The goal of this observational study is to learn about the effectiveness of tirbanibulin among adult subjects with actinic keratosis (AK) lesions in the face.
- Trial name
- CLEAR (NCT07657988)
- Testing
- Tirbanibulin
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Avant Health LLC
Ichthyosis, Lamellar
Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis
Lamellar ichthyosis is a congenital disease of the skin with a generalized scaling. The primary activity of liarozole is considered to be the inhibition of the degradation of a substance called retinoic acid, which is the…
- Trial name
- NCT00282724
- Testing
- Liarozole
- Where
- 16 sites in Belgium, Canada and 7 more
- Volunteers
- 98 people
- Sponsor
- Stiefel, a GSK Company
Multiple Actinic Keratoses
Daylight-PDT for AKs: Comparing Two Photosensitizers (BF-200 ALA and MAL)
The aim of the study is to compare the efficacy of two photosensitizers, methyl-aminolaevulinate (MAL) and 5-aminolaevulinic nanoemulsion (BF-200 ALA) in the treatment of facial actinic keratosis.
- Trial name
- 2013-002108-15 (NCT01893203)
- Testing
- BF-200 ALA cream, MAL cream
- Where
- Finland
- Volunteers
- 14 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Onychomycosis of Toenails
Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail
The purpose of this study is to determine whether AN2690 topical solution is a safe and effective treatment for onychomycosis of the toenail.
- Trial name
- NCT01302119
- Testing
- AN2690 Topical Solution, 5%, Solution Vehicle
- Where
- 32 sites in United States, Canada
- Volunteers
- 604 people
- Sponsor
- Pfizer
Vitiligo, Melanoma (Skin)
Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo
This study examines melanoma and nonmelanoma skin cancer in people diagnosed with vitiligo compared to matched controls.
- Conditions
- Vitiligo, Melanoma (Skin), Nonmelanoma Skin Cancer, Squamous Cell Carcinoma
- Trial name
- NCT04969419
- Testing
- Exposure of skin cancer of interest
- Where
- United Kingdom
- Volunteers
- 75,771 people
- Sponsor
- Momentum Data
Actinic Keratosis
Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses
Actinic keratoses (AK) are common cutaneous lesions associate with chronic ultraviolet radiation exposure. While most authorities consider AK as a pre-malignant lesion, some consider it as an incipient squamous cell carcinoma…
- Trial name
- NCT01229319
- Testing
- Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Frankel, Amylynne, M.D.
Actinic Keratosis, Keratosis, Actinic
Study to Evaluate Safety and Tolerability of BF-200 ALA (Ameluz®) for Photodynamic Therapy in the Treatment of the Expanded Field of Actinic Keratosis on Face and Scalp
The aim of the study is to evaluate the safety and tolerability of PDT for treatment of mild to severe actinic keratosis on the face and scalp in the expanded treatment field using 3 tubes of BF-200 ALA 10% gel (Ameluz®) in…
- Conditions
- Actinic Keratosis, Keratosis, Actinic, Keratosis
- Trial name
- NCT05060237
- Testing
- BF-200 ALA and red light LED lamp
- Where
- 9 sites in United States
- Volunteers
- 112 people
- Sponsor
- Biofrontera Bioscience GmbH
Keratosis Pilaris (KP)
Investigating the Safety and Efficacy of the 1927-nm Thulium Laser in Keratosis Pilaris
Keratosis pilaris (KP) is a very common skin condition that affects up to 80% of adolescents and 40% of adults. Clinically, KP causes rough dry patches and tiny spiny bumps around the hair follicles, as well as redness and…
- Trial name
- KP (NCT07078461)
- Testing
- 1927-nm Thulium Laser therapy
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Actinic Keratosis, Squamous Cell Carcinoma
Nanocytology Test to Evaluate Skin Cancer in High Risk Patients
The purpose of this study is to correlate pathological features from specimens in order to determine if this new molecular diagnostic technique can be used to detect risk of skin cancer.
- Trial name
- NCT01905891
- Testing
- Superficial shave biopsy
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Keratotic Nodular Size
Effect of Thymoquinone Extracted From Nigella Sativa in the Treatment of Arsenical Keratosis
Prepare an ointment from Nigella sativa seeds extract and apply it over palmer arsenical keratosis patient for 12 weeks. After than the effect of the ointment will be observed by measuring the keratotic nodular size before and…
- Trial name
- NCT04686461
- Testing
- Nigella sativa seeds extract containing ointment intervention
- Where
- Bangladesh
- Volunteers
- 34 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Prevalence and Risk Evaluation of Diabetic Complications of the Foot in A Large Canadian Population
The study aims to assess foot complications among patients with diabetes in Canada, using patient data collected during diabetes foot assessments performed by the LMC Chiropody Team between February 27, 2018 and April 17, 2019.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Foot Deformities, Onychauxis
- Trial name
- PEDAL (NCT04327622)
- Where
- Canada
- Volunteers
- 5,084 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Actinic Keratoses
Frequency and Intensity of Local Reactions in Patients Treated With 4% 5-FU vs 4% 5-FU Associated With an Emollient Cream: a Randomised, Controlled Clinical Trial
Transient local skin reactions with topical Actinic Keratosis treatments such as 5-FluoroUracil (5-FU) often lead to non-adhesion from patients and thus to treatment failure.
- Trial name
- NCT04875026
- Testing
- 5-fluorouracil 4% (Tolak), Dexeryl
- Where
- 27 sites in France, Germany and 2 more
- Volunteers
- 146 people
- Sponsor
- Pierre Fabre Medicament
Actinic Keratoses
Tirbanibulin 1% Ointment for the Treatment of Actinic Keratosis on the Back of the Hands
Interventional, monocentric, national, internal placebo-controlled, prospective pilot study, consisting of two parts, A (single-blinded) and B (open) to assess Efficacy of Tirbanibulin for the treatment of AK on the back of the…
- Trial name
- NCT06026358
- Testing
- Tirbanibulin
- Sponsor
- Medical University of Graz
Precancerous Condition
Topical Perillyl Alcohol in Treating Patients With Sun Damaged Skin and Actinic Keratoses
RATIONALE: Drugs used in chemotherapy, such as perillyl alcohol, work in different ways to stop the growth of abnormal cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00608634
- Testing
- perillyl alcohol
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Arizona
Actinic Keratosis
Safety and Toleration of PEP005 Topical Gel When Applied to a Treatment Area of up to 100cm2
Study Hypothesis: Safety and Tolerability will differ when treating multiple contiguous 25 cm2 treatment areas, as compared to individual 25 cm2 treatment areas.
- Trial name
- NCT00659893
- Testing
- PEP005 Topical gel
- Where
- 13 sites in United States, Australia
- Volunteers
- 64 people
- Sponsor
- Peplin
Facial Dermatoses, Seborrheic Keratoses
Dermatosis Papulosa Nigra
DPN is a disorder among darkly pigmented patients, manifested by small, benign, variants of seborrheic keratoses, predominantly on the face.
- Trial name
- DPN (NCT00710203)
- Testing
- Pulsed dye laser, Curettage, Electrodesiccation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Davis