Clinical trials: Ketamine
Subarachnoid Hemorrhage, Aneurysmal
Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding into the space between the brain and the tissues that surround the brain as a result of a ruptured aneurysm and is a type of stroke associated with high morbidity and…
- Trial name
- PENDULUM (NCT05032118)
- Testing
- Ketamine Hydrochloride, Propofol
- Sponsor
- Jenna L Leclerc MD, PhD
Post-traumatic Stress Disorder
Ketamine and Prolonged Exposure in PTSD
This study aims at investigating the effectiveness of the drug, Ketamine, in combination with Prolonged Exposure (PE) therapy for people suffering from PTSD.
- Trial name
- NCT03960658
- Testing
- ketamine-enhanced prolonged exposure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Treatment Resistant Depressive Disorder
A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression
The purpose of this study is to assess the efficacy and dose response of intranasal esketamine (Panel A: 28 mg, 56 mg, and 84 mg and Panel B: 14 mg and 56 mg) compared with placebo in improving depressive symptoms in participants…
- Trial name
- SYNAPSE (NCT01998958)
- Testing
- Esketamine 14 mg, Esketamine 28 mg, Esketamine 56 mg
- Where
- 25 sites in United States, Belgium and 1 more
- Volunteers
- 108 people
- Sponsor
- Janssen Research & Development, LLC
Postoperative Sleep Disturbances
Comparison Of The Effects Of Melatonin Premedication And Ketamine On Postoperative Sleep Quality İn Rhinoplasty
Background Postoperative sleep disorders are common complications of surgery and anesthesia that prolong morbidity and hospital stay. Various methods are being explored to prevent and treat these issues.
- Trial name
- NCT06898463
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine), Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Konya City Hospital
Total Abdominal Hysterectomy
S Ketamine Use in Total Abdominal Hysterectomy
This study investigates the effect of low dose S+ketamine compared to placebo on cumulative morphine consumption at 24 hours in women undergoing open abdominal hysterectomy with remifentanil-propofol target controlled infusion.
- Trial name
- SKET (NCT02543385)
- Testing
- S Ketamine
- Sponsor
- KK Women's and Children's Hospital
Pain, Postoperative
The Efface of Ketamine vs. Lidocaine in the Management of Pain After Laparoscopic Cholecystectomy
This prospective interventional study conducted at Liaquat National Hospital and Medical College compared the analgesic efficacy of ketamine and lidocaine in managing postoperative pain after laparoscopic cholecystectomy.
- Trial name
- NCT07248384
- Testing
- IV ketamine 0.5 mg/kg, IV Lidocain 60 mg/kg
- Where
- Pakistan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Liaquat National Hospital & Medical College
Cardiac Surgery
Investigation of the Anti-inflammatory Effect of Ketamine in Cardiac Surgery
Background: The inflammatory response following cardiac surgery is known to contribute significantly to morbidity and mortality.
- Trial name
- NCT07536633
- Testing
- ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people
- Sponsor
- Konya City Hospital
Major Depressive Disorder
Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. The investigators therefore plan to investigate the feasibility and efficacy of repeated intravenous…
- Trial name
- NCT01667926
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Pediatric Sedation, Clonidine Sedation
Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.
Aim of the work Is to compare between oral ketamine and oral clonidine regarding the level of sedation pre and postoperatively in addition the need of opioids administration intraoperative in children undergoing elective lower…
- Conditions
- Pediatric Sedation, Clonidine Sedation, Ketamine Sedation
- Trial name
- NCT07461376
- Testing
- Oral Clonidine (OC)
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Fibromyalgia
ESKETamine for FIBromyalgia Treatment
Fibromyalgia is a cause of chronic pain, classified by the Internal Classification of Diseases (ICD) as a primary chronic pain with specific diagnostic criteria established by the American College of Rheumatology (ACR).
- Trial name
- ESKEFIB (NCT04436250)
- Testing
- Active comparator, S-Ketamine Low dose, S-Ketamine High dose
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Grand Hôpital de Charleroi
Post-anesthesia Recovery
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
Esketamine is an antagonist of N-methyl-d-aspartate (NMDA) receptor different from other gamma-aminobutyric acid (GABA) receptor agonists.
- Trial name
- NCT06430645
- Testing
- Esketamine, Saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Major Depressive Disorder, Drug Abuse
Ketamine IV Classic Protocol : Five Years Follow up
Patients who suffer from MDD recieved ketamnie (2014-15) in open study will be addressed and there depression mood will be evaluated using the rating scale that were used in the original research.
- Conditions
- Major Depressive Disorder, Drug Abuse, Medications, Relapse
- Trial name
- NCT04824157
- Testing
- Non
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Sheba Medical Center
Postoperative Recovery
Esketamine-propofol Versus Propofol for Flexible Bronchoscopy
Bronchoscopy is a promising technology for lung and bronchus disease detection and therapy. However, this procedure is associated with a relatively high risk of hypoxemia, coughing, wheezing, and dyspnea.
- Trial name
- NCT05643066
- Testing
- 0.1 mg/kg esketamine, 0.2 mg/kg esketamine, 0.9% saline
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Fujian Provincial Hospital
Depressive Episode
Role Of Non-Specific Effects in The Treatment of Depression With Esketamine
The investigators aim to examine the magnitude of non-specific effects in the treatment of depressive episodes with esketamine, by providing patients in the intervention group with a pretreatment presentation and post-treatment…
- Trial name
- ROSETTE (NCT05910775)
- Testing
- Pre and Post Treatment Presentations
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Adenotonsillectomy, Children
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain.
- Conditions
- Adenotonsillectomy, Children, Intranasal Administration, Dexmedetomidine
- Trial name
- NCT07479602
- Testing
- Intranasal dexmedetomidine-esketamine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
Alcohol Use Disorder
Ketamine for the Treatment for Alcohol Use Disorder in the ED
The investigators' approach is to conduct a pilot double-blind, placebo-controlled randomized clinical trial with individuals with alcohol use disorder (AUD) seeking inpatient alcohol detoxification in the emergency department…
- Trial name
- NCT05661669
- Testing
- Ketamine, Saline
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Hemorrhoids, Pain
Effect of Perioperative i.v. Low-dose S(+) Ketamine
The purpose of this study is to determine whether the use of perioperative intravenous S (+) ketamine reduces the amount and degree of postoperative pain.
- Trial name
- NCT00354029
- Testing
- S (+) Ketamine
- Where
- Norway
- Volunteers
- 83 people
- Sponsor
- Asker & Baerum Hospital
Cluster Headache
Effect of Ketamine Intranasal Spray in Treatment of Chronic Cluster Headache
Ketamine has been used clinically IV in a very safe manner by a very small number of clinicians, to treat migraines and CH, and various other rarer pain disorders, including mixed headache and neuropathic pain clinical syndromes.
- Trial name
- NCT04179266
- Testing
- Ketamine
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- CCH Pharmaceuticals
Depression
(GluEsk) Glutamate and Esketamine
Esketamine is the S-enantiomer of racemic ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist. Esketamine and other antidepressant NMDA receptor antagonists are hypothesised to act by producing a rapid increase in brain…
- Trial name
- GluEsk (NCT06432322)
- Testing
- Esketamine nasal spray
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Postoperative Pain
The Ketamine for Acute Postoperative Analgesia (KAPA) Trial
Postoperative pain remains an important challenge for both patients and clinicians. Despite advances in pain management techniques, many patients continue to describe their pain as moderate to severe immediately after surgery.
- Trial name
- KAPA (NCT04646694)
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto