Clinical trials: Ketone Body Metabolism
Nutrition, Obesity and Overweight
The Causal Role of Ketone Bodies in Obesity-associated Disease Prevention - Combining Genetic Epidemiology With a Randomised Trial to Infer Causality
Excess weight increases the risk of several diseases including cardiovascular disease, type 2 diabetes, kidney disease and various cancers.
- Trial name
- KETO-GENETIC (NCT06668168)
- Testing
- Ketone Monoester (KE), Ketogenic diet
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Bath
Overweight and Obesity, Cognitive Change
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults
This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to…
- Conditions
- Overweight and Obesity, Cognitive Change, Psychophysiologic Reaction
- Trial name
- NCT06368297
- Testing
- Ketone Monoester Supplementation, Ketogenic diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Macau
Schizophrenia Disorder
KetoBrain: Brain Energy Metabolism in Schizophrenia
Objective The objective is to recruit antipsychotic-naïve patients at the first diagnosis with a first-episode schizophrenia disorder (FES) to study ketone metabolism of the brain via PET neuroimaging.
- Trial name
- NCT07309172
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ole Köhler-Forsberg
Obesity
Microbiota in Dietary Approach to Obesity
Main aim: Study the anthropometric, metabolic, cardiovascular and neurocognitive and gut microbiota changes of different approaches for the weight reduction that increase the ketone bodies in a different proportion in relation to…
- Trial name
- NCT04453150
- Testing
- Standard hypocaloric die, Intermittent fasting 16/8 (early fasting), Intermittent fasting 16/8 (late fasting)
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Healthy
Endogenous vs. Exogenous Ketone Bodies
Aim of the study is to compare the origin of ketone bodies: endogenous ketone bodies due to 36 hours fasting or 24 hours of ketogenic diet vs. exogenous ketone bodies as supplements additional to normal diet.
- Trial name
- NCT04490226
- Testing
- Beta-Hydroxybutyrate as Ca-Mg-salt, active, ketogenic diet (KetoCal® 4:1 Neutral, Nutricia GmbH, Erlangen, Germany), active, fasting, active
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Kiel