Clinical trials: Ketones, Metabolism
Type 2 Diabetes, Heart Failure, Reduced Ejection Fraction
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT06108076
- Testing
- Ketone Monoester (KE)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Exercise, Ketones
The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source.
- Conditions
- Exercise, Ketones, Dietary Supplements
- Trial name
- NCT02825823
- Testing
- Ketone Salt
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Heart Failure, Ketosis
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Chronic Heart Failure: Cardiovascular Effects
The ketone body 3-hydroxybutyrate (3-OHB) is a naturally occurring energy substrate, and is associated with increased life span and improved health.
- Conditions
- Heart Failure, Ketosis, Ketonemia
- Trial name
- KETO-KINETICS1 (NCT04443426)
- Testing
- Oral 3-hydroxybutyrate salts, Ketone Monoester
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Metabolic Syndrome
Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance
The goal of this single-blind randomized placebo-controlled trial is to test the effects of an oral ketone supplement on appetite, cognition, metabolism, and cardiovascular function in individuals with obesity and insulin…
- Trial name
- NCT05651243
- Testing
- Ketone Ester Supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Mississippi
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
This WP specifically aims to elucidate the effects of IEK on hypoxic tolerance and the development and severity of AMS symptoms, blood and tissue oxygenation status, as well as sleep quality during an episode of acute exposure to…
- Trial name
- NCT05588427
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Menopause
Health, Imaging, and Cognition Across the Menopausal Transition
This observational cross-sectional study aims to better understand how the menopausal transition affects brain energy metabolism and cognition.
- Trial name
- MOSAIC (NCT07021664)
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus, Ketosis
The Effect of a Ketone Drink on Liver Glucose Production in People With Type 2 Diabetes
What is the effect of a ketone drink on liver glucose production, and postprandial glycemia, in people with type 2 diabetes.
- Trial name
- KES2 (NCT05518448)
- Testing
- Ketone - beta-hydroxybutyrate (β-OHB)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Exeter
Athletic Performance, Exercise
Endurance Trial: Ketone and Carbohydrate Supplementation
This randomized, double-blind, crossover study investigates the effects of exogenous ketone supplementation on physical and cognitive performance in amateur endurance athletes during exhaustive exercise.
- Conditions
- Athletic Performance, Exercise, Ketosis, Cognition
- Trial name
- NCT07792876
- Testing
- Carbohydrate beverage, (R)-1,3-butanediol, Standardized evening meal
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Ketogenic Dieting, Ketosis
Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status
The primary purpose of this study is to characterize the performance and utility of a novel breath acetone meter developed by Readout, Inc.
- Trial name
- NCT04130724
- Testing
- Blood ketone testing, Breath ketone testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Readout, Inc.
Diabetes, Hyperglycemia
Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes
Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate "keto" diet.
- Conditions
- Diabetes, Hyperglycemia, Ketosis
- Trial name
- NCT05477368
- Testing
- D-β-hydroxybutyric acid with R-1,3-butanediol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
PreDiabetes
β-hydroxybutyrate, Glucose Metabolism and Prediabetes
The study aims to investigate changes in blood glucose metabolism after administration of a ketone ester drink.
- Trial name
- CETUS (NCT03889210)
- Testing
- HVMN Ketone
- Where
- New Zealand
- Volunteers
- 18 people
- Sponsor
- University of Auckland, New Zealand
Acute Heart Failure (AHF), Cardiogenic Shock
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients…
- Conditions
- Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones
- Trial name
- KADHEF-2 (NCT07527156)
- Testing
- Ketone Monoester (KE)
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Healthy
Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging.
- Trial name
- NCT02410161
- Testing
- alpha-linolenic acid-rich supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Appetite, Obesity
Exogenous Ketones and Appetite
People with obesity have different appetitive responses to stimuli compared to people without obesity. For example, people with obesity have a blunted postprandial ghrelin ('hunger' hormone) response, lower glucagon-like peptide…
- Conditions
- Appetite, Obesity, Ketones, Appetitive Behavior
- Trial name
- NCT06327464
- Testing
- Exogenous ketones
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ketosis
Variations in Ketone Metabolism
This outcome of this study will elucidate how the phenotype of the individual modulates the KE metabolic effect. Most studies of KE have been in homogenous populations, usually young, male athletes.
- Trial name
- STAK-VKM (NCT05924295)
- Testing
- Ketone Supplement, Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale, Blood Draw
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Gastrointestinal Infections, Ketosis
Oral Glucose Intervention for Children With Gastroenteritis and Ketosis
Fasting ketoacidosis adds morbidity to children affected by gastrointestinal infections. The investigators investigate oral glucose gel for its effectiveness in rapidly reducing ketoacidosis and for improvements in oral hydration…
- Trial name
- NCT02729870
- Testing
- Oral Glucose Gel
- Sponsor
- University of Florida
Type2 Diabetes, Remodeling, Ventricular
Comparison of the Effects of Dapagliflozin and Gemigliptin on Ketone Metabolism and Cardiac Remodeling in Type 2 Diabetes
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated cardiovascular and renal protection in patients with type 2 diabetes (T2D); however, the underlying mechanism remains unclear.
- Trial name
- NCT05194592
- Testing
- Dapagliflozin, Gemigliptin
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Wonju Severance Christian Hospital
Diabetic Cardiomyopathies, Heart Failure
Diabetic Cardiomyopathy and Heart Failure
This study will demonstrate the beneficial effects of ketone bodies in type 1 diabetes (T1D) patients and will have significant translational applications to prevent serious metabolic conditions such as T1D induced diabetic…
- Trial name
- NCT05571865
- Testing
- Probiotic
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Diabetes Mellitus, Fat; Intolerance, Pancreas
Effect of Empagliflozin on Body Composition and Ketones
The purpose of this study is to evaluate changes of body composition induced by Sodium-glucose cotransporter-2 (SGLT2) inhibitor and its metabolic consequence in Korean type 2 diabetes (T2D).
- Trial name
- NCT03877406
- Testing
- Empagliflozin 10 MG, Hypoglycemics Oral
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetes Mellitus, Glucose
The GLOW Study - The YANG System
This is an open label, interventional, monocentric, prospective early feasibility study, designed to evaluate the safety of implant and short-term integration into the tissue of the YANG sensor.
- Trial name
- NCT04782934
- Testing
- The YANG SENSOR is an active implantable device, for Real Time Continuous Glucose, Lactate and Ketone Measurement
- Where
- Belgium
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Indigo Diabetes NV