Clinical trials: Ketones, Metabolism
Urinary Tract Infections, Proteinuria
Scanadu Urine Device Validation Study Protocol
This study will test Scanadu Urine Device for clinical performance and usability.
- Conditions
- Urinary Tract Infections, Proteinuria, Ketone Urine, Hematuria
- Trial name
- NCT02973178
- Testing
- Scanadu Urine Device
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Scanadu, Inc.
Type2 Diabetes, Heart Failure With Preserved Ejection Fraction
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
The study team will examine the effects of SGLT2i (and SGLT2i-induced increases in plasma ketone concentrations) on skeletal muscle and cardiac ketone uptake, skeletal muscle bioenergetics, cardiopulmonary exercise capacity, and…
- Trial name
- NCT05057806
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Type 2
SGLT2 Inhibitors and Effects on Hematopoiesis, Inflammation and Metabolic Markers
Study of the response to SGLT2 inhibitors in type 2 diabetic patients with relevance to the erythropoesis and indexes of cardiorenal function.
- Trial name
- SGLT2HgB (NCT05408936)
- Testing
- SGLT2 inhibitor
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- University of Patras
Ketosis, Diabetic
Exogenous Ketones in People With Type 1 Diabetes
The aim of this pilot study is to investigate the metabolic effects of exogenous ketone ester food supplements, by assessing the change in blood acid-base balance, and the level of blood beta-hydroxy-butyrate in people with type…
- Trial name
- NCT04487678
- Testing
- Ketone ester supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes, Hyperglycemia
Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes
Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate "keto" diet.
- Conditions
- Diabetes, Hyperglycemia, Ketosis
- Trial name
- NCT05477368
- Testing
- D-β-hydroxybutyric acid with R-1,3-butanediol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Diabetes, Type1diabetes
Continuous Ketone Monitoring in People With Type 1 Diabetes Using SGLT2 Inhibitors
Type 1 diabetes is an autoimmune disease where the body attacks the insulin-producing cells in the pancreas. In the absence of insulin, the body is unable to effectively use glucose for energy, resulting in high blood sugar…
- Conditions
- Diabetes, Type1diabetes, T1D
- Trial name
- EmpaCKM (NCT06753994)
- Testing
- SGLT-2 inhibitor
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Ketonemia, Ketosis
Exogenous Ketone Supplementation and Exercise Performance
20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo.
- Trial name
- NCT03895892
- Testing
- 20 km time trial, Wingate test, Ketone/Caffeine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Asthma, Obesity
Nutrition for Asthmatics with Obesity
This study will test the effect of diet on asthma in individuals with obesity.
- Trial name
- NCT05222451
- Testing
- DGA Diet, MCT Diet, KETO Diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pennington Biomedical Research Center
Alcohol Use Disorder, Alcohol Withdrawal
Does a Ketogenic Dietary Supplement Reduce Alcohol Withdrawal Symptoms in Humans?
A ketogenic diet (KD) is high in fat and low in carbohydrates and induces ketosis. KD is an approved non-pharmacological therapy for drug-resistant child epilepsy.
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KME (NCT03878225)
- Testing
- H.V.M.N. Ketone Ester
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Ketosis, Exercise Performance
Ketone Supplementation and Exercise Performance
The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).
- Conditions
- Ketosis, Exercise Performance, Ketoses, Metabolic
- Trial name
- NCT03954665
- Testing
- 10 km time trial, 30s Wingate, Ketone
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Bipolar Disorder
Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones
Small exploratory open-label pilot study to assess supplementation of a ketone ester (Juvenescence) combined with a 'ketogenic-mimicking diet' as a potential therapy for persons with bipolar disorder.
- Trial name
- BIPO (NCT06335875)
- Testing
- Ketone Ester Beverage, Low Glycemic Index Diet
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Sleep and Recovery in Hypoxia
This study specifically aims to elucidate the effects of IEK on sleep and recuperation in hypoxia, after training in normoxia. These conditions are in line with the widely applied live-high train-low strategy.
- Conditions
- Ketosis, Hypoxia, Sleep
- Trial name
- NCT06060093
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy Participants
The Effect of Ketone Monoesters on Skeletal Muscle Protein Synthesis and Whole-body Protein Metabolism.
The ketone β-hydroxybutyrate (BHB) is endogenously produced during periods of low glucose availability, serving as an alternative metabolic fuel.
- Trial name
- WAKM (NCT07082309)
- Testing
- Ketone Monoester (KE) and whey protein beverage, Control
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KSAW (NCT06559995)
- Testing
- ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Healthy Adults
Comparing the Ketogenic Effect of Coconut Oil and Different MCTs
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults.
- Trial name
- MCT-Coco (NCT02679222)
- Testing
- Coconut oil, Coconut oil + MCT, MCT
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketosis, Glucose Metabolism
Ketone Supplements and Substrate Oxidation and Physical Performance
The objective of this randomized crossover study is to examine the influence of consuming a ketone ester plus carbohydrate (KE+CHO) supplement on substrate oxidation and physical performance in 15 healthy adults.
- Trial name
- NCT04737694
- Testing
- Ketone ester, Glucose
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Insulin Resistance, Obesity & Overweight
Effects of Ketone Bodies on Insulin Sensitivity
KETO-SENSE is a clinical research study investigating how ketone bodies affect energy metabolism and insulin sensitivity in humans.
- Conditions
- Insulin Resistance, Obesity & Overweight, Energy Metabolism, Ketone Body Metabolism
- Trial name
- KETO-SENSE (NCT07359625)
- Testing
- Growth Hormone, Human, Oral ketone supplement (KetoAid®, KE4)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 1 Diabetes, Type 2 Diabetes
Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors
The purpose of this research is to see how well a special education plan using continuous ketone monitoring (DGK) works to lower the risk of a condition called diabetic ketoacidosis (DKA) in people with type 1 diabetes (T1D)…
- Trial name
- KARMA (NCT07421518)
- Testing
- SGLT-2 inhibitor (Sotagliflozin), Insulin withdrawal test (IWT)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Exercise, Ketosis
The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency.
- Trial name
- NCT05665855
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- McMaster University
Overweight, Mood
Effects of a Ketogenic Diet on Psychological Outcomes
The aim of the study is to investigate how glycemia and ketonemia variations during three different diet protocols: a ketogenic diet without any restriction on calories intake (KD), a calorie-restricted ketogenic-mediterranean…
- Conditions
- Overweight, Mood, Appetitive Behavior
- Trial name
- NCT04086498
- Testing
- Mediterranean diet, KEMEPHY, KD
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Padova