Clinical trials: Ketones, Metabolism
Ketosis
Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More
This study aims to address two key aspects. First, the suitability of selecting a specific sampling site for BHB measurement in patients and research, as well as potential differences between capillary and venous blood…
- Trial name
- NCT06053138
- Testing
- Ketone monoester
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Central Jutland Regional Hospital
Healthy Young Adults
Effects of Exogenous Ketones in Healthy Young Adults
Exogenous ketone supplements in the form of beta-hydroxybutyrate can be utilized as an alternate energy source (in place of glucose) for all cells except red blood cells.
- Trial name
- NCT03452761
- Testing
- Ketone Salts
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Augusta University
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
This WP specifically aims to elucidate the effects of IEK on hypoxic tolerance and the development and severity of AMS symptoms, blood and tissue oxygenation status, as well as sleep quality during an episode of acute exposure to…
- Trial name
- NCT05588427
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Obesity, Cognitive Change
Effects of Weight Loss Management on Cognitive Function in Elderly Women With Obesity
According to studies, the risk of cerebrovascular disease and cognitive decline are associated with age-related changes. In addition, there is data suggesting a relationship between the progression of this pathology and the…
- Trial name
- NCT05841173
- Testing
- "PanTrek", Physical Trainings, Diet
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Federal State Budgetary Scientific Institution
Parkinson Disease, Alzheimer Disease
Effect of Exercise, Endocannabinoids and Ketones on Cerebral Metabolism in a Cognitive Disorders Population
A two months intervention in which two groups of cognitive disorders, Parkinson and Alzheimer's disease, will receive 50g/day of a commercial MCT supplement combined with supervised aerobic exercise 3 times/week.
- Trial name
- PARKA (NCT04322461)
- Testing
- Betaquik MCT supplement
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Université de Sherbrooke
Exercise, Ketones
The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source.
- Conditions
- Exercise, Ketones, Dietary Supplements
- Trial name
- NCT02825823
- Testing
- Ketone Salt
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
ICU Delirium, Critical Illness
Exogenous Ketone Supplementation in ICU Delirium
Delirium is a common syndrome in intensive care unit (ICU) patients. Those experiencing delirium may suddenly feel confused, have trouble thinking clearly, struggle to pay attention, or see and hear things that are not real.
- Trial name
- KETONES-ICU (NCT07364162)
- Testing
- Ketone monoester
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Kidney Failure, Chronic
Acetoacetate and Acetate Metabolism in Patients With Chronic Kidney Failure.(RENO-TEP)
The objective of this study is to nake a comparison between 11c-acetate and 11c-acetoacetate kidney uptake in chronic kidney failure patients.
- Trial name
- RENO-TEP (NCT05968391)
- Testing
- PET scan metabolic day
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Healthy Aging
Reduced Carbohydrates + Ketogenic Supplement on Energy Metabolism
The present study will evaluate the effects on glucose, ketones and other blood biomarkers, cognition, quality of life, physical activity and well-being of a reduced carbohydrate diet paired with a ketogenic product for 2 months…
- Trial name
- SAGE-2 (NCT06455982)
- Testing
- reduced carbohydrate menu combined with ketogenic supplement
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
PreDiabetes
β-hydroxybutyrate, Glucose Metabolism and Prediabetes
The study aims to investigate changes in blood glucose metabolism after administration of a ketone ester drink.
- Trial name
- CETUS (NCT03889210)
- Testing
- HVMN Ketone
- Where
- New Zealand
- Volunteers
- 18 people
- Sponsor
- University of Auckland, New Zealand
PTSD, Ketosis
Ketone Supplementation in Individuals With PTSD
The purpose of this study is to determine if a 6-week period of ketone salt supplementation affects physiological, emotional, cognitive, and/or behavioral health markers in individuals with PTSD.
- Trial name
- NCT04083352
- Testing
- Pruvit Ketomax Ketone Salt
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Augusta University
Acute Stroke
Effects of a Ketogenic Diet on Acute Stroke
The purpose of this controlled, randomized intervention is to investigate whether a fat-based (ketogenic) diet given for a week has a positive effect on blood sugar, mortality and function in patients hospitalized with acute…
- Trial name
- NCT01997749
- Testing
- Ketocal 4:1 (Nutricia), Control diet: Regular diet offered at the hospitals, Ketogenic meals
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Copenhagen
Ketosis, Diabetic
Exogenous Ketones in People With Type 1 Diabetes
The aim of this pilot study is to investigate the metabolic effects of exogenous ketone ester food supplements, by assessing the change in blood acid-base balance, and the level of blood beta-hydroxy-butyrate in people with type…
- Trial name
- NCT04487678
- Testing
- Ketone ester supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Migraine, Ketogenic Dieting
Th Effect of Ketogenic Metabolic Nutritional Pattern on High-frequency Episodic Migraine (EMIKETO)
The study aims to investigate the impact of 2 nutritional patterns on high-frequency episodic migraine. Subjects enrolled will be randomized in two arms: a) very-low-calorie-ketogenic-diet (VLCKD), b) hypocaloric balanced non…
- Conditions
- Migraine, Ketogenic Dieting, Weight Loss, Overweight
- Trial name
- EMIKETO (NCT04360148)
- Testing
- very-low-calorie-ketogenic-diet, hypocaloric-balanced-diet
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- New Penta SRL
Nutrition, Ketogenic Diet
Dietary Macronutrients and Gut Microbiota, Inflammation, and Metabolic Markers
This 12-week randomized controlled trial will investigate the effects of dietary patterns with different macronutrient compositions on gut microbiota, intestinal inflammation, gene expression, and metabolic health in healthy…
- Conditions
- Nutrition, Ketogenic Diet, Gene Expression, Diet
- Trial name
- DIETMICRO (NCT07672691)
- Testing
- Ketogenic Diet (KD), Vegetarian Diet (VD), Control Diet (CD)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Evaluate Ketogenic Stress
An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes
The study investigations include evaluation of the acute effects of a single dose of dapagliflozin (10mg), exenatide (5µg), a combination of exenatide and dapagliflozin or placebo under insulinopenic condition and the long term…
- Trial name
- NCT02962492
- Testing
- Exenatide/Exenatide extended release, Dapagliflozin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University at Buffalo
Diabetes
Method Comparison/User Evaluation of the i-SENS Self-Monitoring Blood Glucose / β-Ketone System
The goal of this clinical trial is to assess the accuracy and usability of the blood glucose meter in untrained participants, both with or without diabetes, as well as those with pre-diabetes.
- Trial name
- NCT05833100
- Testing
- CareSens PRO GK Blood Glucose/b-Ketone Monitoring system
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- i-SENS, Inc.
VLCAD Deficiency, Fatty Acid Oxidation Defects
Acute Nutritional Ketosis in VLCAD Deficiency
To test if a ketone-ester based drink can boost muscle mitochondrial function in vivo in patients with VLCADD in order to establish a rational basis for therapeutic use in this disorder.
- Trial name
- NCT03531554
- Testing
- ketone ester drink, exercise, muscle biopsy
- Where
- 2 sites in Netherlands
- Volunteers
- 5 people
- Sponsor
- University Medical Center Groningen
Obesity, Body Weight
Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation
Background: Time restricted eating (TRE) is a form of fasting in which a person eats only during a set window of time, which is usually between 4 and 10 hours each day.
- Trial name
- NCT06169137
- Testing
- Early Time-Restricted Eating, Conventional dietary regimen (12-hr, 9:30a-9:30p)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overweight, Mood
Effects of a Ketogenic Diet on Psychological Outcomes
The aim of the study is to investigate how glycemia and ketonemia variations during three different diet protocols: a ketogenic diet without any restriction on calories intake (KD), a calorie-restricted ketogenic-mediterranean…
- Conditions
- Overweight, Mood, Appetitive Behavior
- Trial name
- NCT04086498
- Testing
- Mediterranean diet, KEMEPHY, KD
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Padova