Clinical trials: Ketones
Alzheimer Disease
Study to Compare the Pharmacokinetics of Daily Administration of Tricaprilin on Ketone Body Production
This is a Phase I, single center, open label, multiple dose, pharmacokinetic (PK) study recruiting healthy older subjects.
- Trial name
- NCT04268953
- Testing
- Tricaprilin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cerecin
Healthy
Evaluation of PK of Caprylic Triglyceride Oil, AC-1202, AC-1204, and Axona on Ketone Body Production
To compare serum ketone body (i.e., total ketones, β hydroxybutyrate, and estimate of acetoacetate) levels after single dose administration of caprylic triglyceride (CT) oil, AC-1202, AC-1204, and Axona®.
- Trial name
- NCT02833012
- Testing
- Caprylic Triglyceride Oil, AC-1202, Axona
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cerecin
Healthy Men and Women
Ketone Plasma Kinetics After Oral Intake of Different Ketogenic Formulae
This research project aims at evaluating the effect of various ketone precursors and their formulations on blood ketone level after oral intake. Evaluation of the GI tolerability of the various formula will be also evaluated.
- Trial name
- NCT05058157
- Testing
- different ketogenic formulae
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
Evaluation of PK of AC-1204 Mixed in Water, AC-1202 Mixed in Water, and AC-1202 Mixed in Ensure® on Ketone Body Production
To compare serum ketone body (i.e., total ketones, β hydroxybutyrate, and estimate of acetoacetate) levels after single dose administration of AC-1204 mixed in water, AC-1202 mixed in water and AC-1202 mixed in Ensure®.
- Trial name
- NCT02959710
- Testing
- AC-1204 mixed in water, AC-1202 mixed in water, AC-1202 mixed in Ensure®
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cerecin
Tolerance
Tolerance and Safety of a Ketone-Promoting Food Ingredient
The objective of this study is to capture information on tolerance and safety of a ketone-promoting food ingredient in healthy adults.
- Trial name
- NCT04707989
- Testing
- Ketone- Promoting Food Ingredient #1, Ketone- Promoting Food Ingredient #2
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- BHB Therapeutics, Ireland LTD
Ketogenic Dieting, Ketosis
Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status
The primary purpose of this study is to characterize the performance and utility of a novel breath acetone meter developed by Readout, Inc.
- Trial name
- NCT04130724
- Testing
- Blood ketone testing, Breath ketone testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Readout, Inc.
Diabetes
Method Comparison/User Evaluation of the i-SENS Self-Monitoring Blood Glucose / β-Ketone System
The goal of this clinical trial is to assess the accuracy and usability of the blood glucose meter in untrained participants, both with or without diabetes, as well as those with pre-diabetes.
- Trial name
- NCT05833100
- Testing
- CareSens PRO GK Blood Glucose/b-Ketone Monitoring system
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- i-SENS, Inc.
Hypoxia, Ketosis
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
This study will investigate the effects of ketone ester drinks on cognitive performance in hypoxia.
- Trial name
- NCT03659825
- Testing
- Ketone Ester, Hypoxic exposure
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HVMN Inc
Diabetes
A Comparison of Measurements of Ketone Body Flux Versus Ketone Body Concentration as a Pharmacodynamic Marker of Hepatic Fatty Acid Oxidation (0000-110)
This study will compare two approaches to the measurement of fatty acid oxidation (ketone body flux and ketone body concentration) and determine which method demonstrates superior sensitivity and variability in the detection of…
- Trial name
- NCT00860392
- Testing
- Stable isotope tracer (13-C(4)-BHB)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Fasting
Effects of Fast Bar on Physiological Fasting
This study evaluates how Fast Bar(TM), a specially formulated energy bar, affects the physiological condition in participants after an overnight fasting.
- Trial name
- FastBar (NCT04499599)
- Testing
- Dinner, Fasting, Study food
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- L-Nutra Inc
Alzheimer Disease
Study to Compare the Pharmacokinetics of Tricaprilin Formulations and a Placebo on Ketone Body Production
Phase 1, Single-center, Open-label Study, Healthy Adult Male Subjects. Part 1:Single-dose, Placebo-controlled, 3-Way Crossover PK Study Part 2: Single dose 2-way comparator PK Study
- Trial name
- NCT03971123
- Testing
- Tricaprilin
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cerecin
Alzheimer Disease
Pharmacokinetics of Tricaprilin Including Food Effect on Ketone Body Production
This is a Phase I, single center, open label, fixed-order, crossover, food-effect, pharmacokinetic (PK) study recruiting healthy, adult, male subjects.
- Trial name
- NCT03551769
- Testing
- tricaprilin, standard meal, high-fat meal
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cerecin
Urinary Tract Infections, Proteinuria
Scanadu Urine Device Validation Study Protocol
This study will test Scanadu Urine Device for clinical performance and usability.
- Conditions
- Urinary Tract Infections, Proteinuria, Ketone Urine, Hematuria
- Trial name
- NCT02973178
- Testing
- Scanadu Urine Device
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Scanadu, Inc.
Alzheimer Disease
Medical Food Formulation Pharmacokinetic (PK) Study in Medium Chain Triglycerides
This is a Phase I, open label, randomized, 6-way crossover, pilot PK study
- Trial name
- NCT03635879
- Testing
- MCTprocal medical food, Milk/tricaprilin oil blend, AC-1207
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cerecin
Healthy
AN OPEN-LABEL, ACUTE CLINICAL TRIAL TO ASSESS THE LEVEL OF KETONE PRODUCTION FOLLOWING CONSUMPTION OF AVELA™ (R)-1,3-BUTANEDIOL IN AN ADULT POPULATION
The purpose of the pilot clinical trial described herein is to determine the level of ketone production [measured as β hydroxybutyrate (BHB)] following consumption of (R)-1,3-butanediol in a beverage and to record…
- Trial name
- NCT05384106
- Testing
- (R)-1,3-butanediol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Genomatica Inc.
Healthy
Evaluation of PK of AC1204 v Caprylic Triglyceride Oil Incl Food Effect on Ketone Body Production
To compare serum ketone body (i.e., total ketones and β-hydroxybutyrate) levels after administration of AC-1204 versus caprylic triglyceride (CT) oil, both after a standard breakfast.
- Trial name
- NCT02747602
- Testing
- AC-1204, caprylic triglyceride oil (standard breakfast), caprylic triglyceride oil (high fat breakfast)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cerecin
Fasting
Effects of Fast Bar on Intermittent Fasting
This study evaluates how Fast Bar(TM), a specially formulated energy bar, when consumed with coffee or tea, affects the physiological condition in participants after an overnight fasting.
- Trial name
- FastBar2 (NCT04790552)
- Testing
- Dinner, Fasting, Fast Bar
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- L-Nutra Inc
Pharmacokinetics
Pharmacokinetics of Two Fatty Acid Ketone Esters
Randomized, cross over pharmacokinetic study of a novel ketone di-ester and C6 ketone di-ester in ready to drink beverage matrices.
- Trial name
- NCT05686083
- Testing
- C6 ketone di-ester, Novel ketone di-ester
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- BHB Therapeutics, Ireland LTD
Diabetes Mellitus, Ketosis, Diabetic
StatStrip Glucose/Ketone Meter System Ketone Evaluation
The Nova StatStrip Glucose / Ketone Meter System is a fast, simple, whole blood system that can be used to quantify both glucose and ketones using two distinct test strips.
- Trial name
- NCT05118061
- Testing
- Ketone
- Where
- 3 sites in United States, Germany
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Nova Biomedical
Diabetes Mellitus, Glucose
The GLOW Study - The YANG System
This is an open label, interventional, monocentric, prospective early feasibility study, designed to evaluate the safety of implant and short-term integration into the tissue of the YANG sensor.
- Trial name
- NCT04782934
- Testing
- The YANG SENSOR is an active implantable device, for Real Time Continuous Glucose, Lactate and Ketone Measurement
- Where
- Belgium
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Indigo Diabetes NV