Clinical trials: Ketorolac
Cataract
Acular LS vs. Nevanac in Post op Inflammation Following Cataract Surgery
The purpose of this study is to compare the clinical outcomes, safety and efficacy in patients randomized to receive either ketorolac or nepafanac following cataract surgery.
- Trial name
- NCT00348582
- Testing
- Ketorolac, Nepafenac
- Where
- United States
- Sponsor
- Innovative Medical
Cataract Extraction
A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery
This is a 16 day study to evaluate the safety and efficacy of ketorolac eye drops for the treatment of inflammation and pain associated with cataract surgery
- Trial name
- NCT00521456
- Testing
- ketorolac eye drops
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- Allergan
Healthy Volunteers
Study to Determine the Tolerability, Safety and Pharmacokinetics of Ketorolac Tromethamine by Intranasal Administration in Healthy Volunteers
This was a phase 1, open label, multiple dose study in healthy male and female volunteers. Subjects received intranasal ketorolac tromethamine (30 mg) three times daily (t.i.d.) for three days (seven doses in total).
- Trial name
- NCT01363050
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients
Evaluation of the aqueous concentrations of 2 topical NSAIDS as well as the PGE2 inhibition in human patients.
- Trial name
- NCT00347503
- Testing
- ketorolac 0.4%, bromfenac 0.09%
- Where
- United States
- Sponsor
- Innovative Medical
Conjunctivitis, Bacterial
Assessment of the Effects and Tolerability of RD03/2016 for the Treatment of Bacterial Conjunctivitis in Adults
This is a phase II, randomized, parallel-group, blinded-assessor, multicentre study to assess the non-inferiority of RD03/2016 eye drops vs.
- Trial name
- MIRAKLE (NCT06616922)
- Testing
- RD03/2016 eye drops, Levofloxacin 0.5% eye drops solution (Oftaquix®)
- Where
- 41 sites in Germany, Italy and 2 more
- Volunteers
- 252 people
- Sponsor
- NTC srl
Pain
SPRIX in 0 to 11 Year-Old Patients Undergoing Open Surgical Procedures
The purpose of this study is to evaluate the pharmacokinetics and safety of postoperative administration of SPRIX in pediatric patients (ages 0-11) undergoing open surgical procedures.
- Trial name
- NCT02102516
- Testing
- SPRIX(intranasal ketorolac tromethamine)
- Where
- 4 sites in Poland
- Volunteers
- 45 people
- Sponsor
- Egalet Ltd
Postoperative Pain
Safety and Efficacy of Multiple Doses of Ketorolac Tromethamine Administered Intranasally for Postoperative Pain
This was a randomized, double-blind, placebo-controlled study in subjects who underwent major surgery. Each subject's study participation consisted of a screening visit and a treatment period of up to 5 days.
- Trial name
- NCT01347853
- Testing
- Ketorolac tromethamine
- Where
- New Zealand
- Volunteers
- 300 people
- Sponsor
- Egalet Ltd
Breast Cancer
SRG-514 Administered Intraoperatively to Patients Undergoing Breast-conserving Cancer Surgery
This is a multicenter, first-in-human (FIH), open label, Phase 1 dose escalation and recommended Phase 2 dose (RP2D) extension trial with a primary objective to define the RP2D of SRG-514 when administered intraoperatively to…
- Trial name
- NCT06300411
- Testing
- SRG-514
- Where
- 8 sites in United States
- Volunteers
- 25 people
- Sponsor
- SURGE Therapeutics
Healthy
Platelet Function and Safety After IV and Oral Diclofenac, IV Ketorolac and Oral Aspirin in Adult Volunteers
This study will assess platelet function and safety in healthy male volunteers following doses of intravenous diclofenac compared to oral diclofenac (Cataflam), intravenous ketorolac and oral aspirin.
- Trial name
- NCT00548678
- Testing
- intravenous diclofenac sodium (DIC075V), ketorolac, oral diclofenac (Cataflam)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Javelin Pharmaceuticals
Postsurgical Pain
Efficacy and Safety Study of Ketorolac / Pitofenone / Fenpiverinium for the Treatment of Patients With Pain After Surgical Abdominal and Pelvic Operations
Neospastil (ketorolac tromethamine / pitofenone hydrochloride / fenpiverinium bromide fixed-dose combination) in a form of solution for injections and film-coated tablets has been studied as a treatment for pain after surgical…
- Trial name
- NCT05607641
- Testing
- Ketorolac tromethamine, solution for injection then Neospastil, film-coated tablets, Ketorolac tromethamine, solution for injection then Ketorolac tromethamine, coated tablets, Neospastil, solution for injection then Neospastil, film-coated tablets
- Where
- 14 sites in Ukraine
- Volunteers
- 424 people
- Sponsor
- Darnitsa Pharmaceutical Company
Assess Pharmacokinetics of Ketorolac Tromethamine Intranasal and Assess Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
Study to Assess the PK of Ketorolac Tromethamine Intranasal and to Assess the Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
This was an open label, two way crossover study in healthy male subjects. Two treatments were administered to each subject, one treatment per study period, in a randomized manner.
- Trial name
- NCT01363089
- Testing
- Ketorolac tromethamine, Oxymetazoline hydrochloride
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Acute Gouty Arthritis, Acute Pain
Treatment of Topical Ketorolac Gel in Acute Gouty Flare
This study will be a phase 1, open-label, bioavailability, safety and PK study of topically applied transcutaneous ketorolac tromethamine gel 12.5% (/w) (NOV-1776) versus intravenous administration of approved ketorolac…
- Conditions
- Acute Gouty Arthritis, Acute Pain, Gout Flare
- Trial name
- NCT06273813
- Testing
- Ketorolac Tromethamine 15 MG/ML, Ketorolac Tromethamine
- Where
- 2 sites in Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Novilla Pharmaceuticals
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects
The purpose of this study is to compare the ability of two different topical NSAIDs (non-steroidal anti-inflammatory medications used for pain relief) to reach the back of the eye and to stop inflammation.
- Trial name
- NCT00469690
- Testing
- Acular, Xibrom
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Pharmacokinetics
Administration of Tramadol and Ketorolac Separately and Simultaneously to Assess a Potential Pharmacokinetic Interaction
Tramadol (Tradol) and ketorolac (Dolac) are marketed products to treat acute pain. This study was performed to determine if both medications can be given to a patient simultaneously without a change of the products'…
- Trial name
- NCT03767036
- Testing
- Tramadol hydrochloride 25 mg capsule, Ketorolac Tromethamine 10 mg tablet
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Pain
Efficacy of Intravenous Ibuprofen Compared to Intravenous Ketorolac for Pain Control Following Arthroscopic Knee Surgery
The purpose of this study is to assess the efficacy of intravenous ibuprofen compared to ketorolac for the treatment of postoperative pain as measured by patient pain intensity (Visual Analog Scale, VAS)
- Trial name
- NCT01901393
- Testing
- IV ibuprofen, Ketorolac
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Cumberland Pharmaceuticals
Macula Thickening
Efficacy of Topical Ketorolac Versus Placebo for Improving Visual Outcomes Following Multifocal IOL Implantation
The purpose of this study was to evaluate the efficacy of ketorolac 0.4% on quality of vision and macula thickening in patients undergoing cataract surgery using the ReStor® multifocal IOL.
- Trial name
- NCT00433225
- Testing
- Prednisolone Acetate, Ketorolac 0.4%, Gatifloxacin 0.3%
- Where
- United States
- Sponsor
- Innovative Medical
Back Pain
Comparison Of Ketorolac Tromethamine Oral Drops Versus Naproxen For Moderate to Severe Back Pain Treatment
The purpose of this study is to evaluate the non-inferiority clinical efficacy of two different drugs in the treatment of patients diagnosed with moderate to severe back pain treatment.
- Trial name
- NCT01471899
- Testing
- Ketorolac Tromethamine, Naproxen
- Volunteers
- 78 people
- Sponsor
- EMS
Pain, Dental Impaction
A Single-dose Study of Intranasal Ketorolac in the Treatment of Pain Secondary to Dental Impaction Surgery
The purpose of this study is to evaluate the analgesic efficacy of a single intranasal (IN) administration of ketorolac after dental impaction surgery.
- Trial name
- NCT01356225
- Testing
- Ketorolac tromethamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Egalet Ltd
Cataract
Ketorolac vs. Steroid in the Prevention of CME
Evaluate if the incidence of sub clinical CME can be significantly reduced by use of peri-operative Acular LS plus Pred Forte when compared with Pred Forte alone in normal cataract patients.
- Trial name
- NCT00348244
- Testing
- Ketorolac, Prednisolone Acetate
- Where
- United States
- Sponsor
- Innovative Medical
Rhinitis, Allergic, Seasonal, Conjunctivitis, Allergic
Safety and Efficacy of Olopatadine Hydrochloride/Ketorolac Tromethamine Ophthalmic Solution Compared With Olopatadine Hydrochloride Ophthalmic Solution in Patients With Seasonal Allergic Conjunctivitis
This study will investigate the safety and efficacy of olopatadine hydrochloride / ketorolac tromethamine fixed dose combination ophthalmic solution compared with olopatadine hydrochloride ophthalmic solution in patients with…
- Trial name
- NCT01258309
- Testing
- olopatadine hydrochloride /ketorolac tromethamine fixed dose combination ophthalmic solution, olopatadine hydrochloride 0.1% ophthalmic solution
- Where
- India
- Volunteers
- 129 people
- Sponsor
- Allergan