Clinical trials: Ketorolac
Post-ERCP Acute Pancreatitis
Rectal Indomethacin vs Intravenous Ketorolac
Endoscopic retrograde cholangiopancreatography (ERCP) is an essential procedure that can be complicated by post-ERCP pancreatitis (PEP). Indomethacin and ketorolac are two medications used to prevent PEP.
- Trial name
- NCT05664074
- Testing
- Rectal indomethacin, IV ketorolac
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- David Vitale MD
Healthy Volunteers
Study to Determine the Tolerability, Safety and Pharmacokinetics of Ketorolac Tromethamine by Intranasal Administration in Healthy Volunteers
This was a phase 1, open label, multiple dose study in healthy male and female volunteers. Subjects received intranasal ketorolac tromethamine (30 mg) three times daily (t.i.d.) for three days (seven doses in total).
- Trial name
- NCT01363050
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Pain
Pre-operative Ketorolac Administration Has no Pre-emptive Analgesic Effect Following Total Abdominal Hysterectomy
Background: Experimental models using short duration noxious stimuli have led to the concept of pre-emptive analgesia. Ketorolac, a non-steroidal anti-inflammatory drug (NSAID), has been shown to have a post-operative narcotic…
- Trial name
- NCT02642718
- Testing
- Ketorolac Tromethamine
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 48 people
- Sponsor
- Hospital Arquitecto Marcide
Probable Migraine, Migraine With Aura
Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department
Migraine headaches are a common problem for children. When treatment at home fails, children may benefit from intravenous treatment administered in a hospital setting like the Emergency Department.
- Conditions
- Probable Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- EDMigraine-4 (NCT01596166)
- Testing
- Ketorolac Tromethamine, Metoclopramide
- Where
- 2 sites in Canada
- Volunteers
- 56 people
- Sponsor
- University of Alberta
Pancreatitis
A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis
Determine if IV ketorolac is an effective agent in the prevention of post-ERCP pancreatitis. Determine if IV ketorolac provides improved post-procedure analgesia.
- Trial name
- NCT02465138
- Testing
- Ketorolac
- Where
- 2 sites in United States
- Sponsor
- University of California, San Francisco
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients
Evaluation of the aqueous concentrations of 2 topical NSAIDS as well as the PGE2 inhibition in human patients.
- Trial name
- NCT00347503
- Testing
- ketorolac 0.4%, bromfenac 0.09%
- Where
- United States
- Sponsor
- Innovative Medical
Conjunctivitis, Bacterial
Assessment of the Effects and Tolerability of RD03/2016 for the Treatment of Bacterial Conjunctivitis in Adults
This is a phase II, randomized, parallel-group, blinded-assessor, multicentre study to assess the non-inferiority of RD03/2016 eye drops vs.
- Trial name
- MIRAKLE (NCT06616922)
- Testing
- RD03/2016 eye drops, Levofloxacin 0.5% eye drops solution (Oftaquix®)
- Where
- 41 sites in Germany, Italy and 2 more
- Volunteers
- 252 people
- Sponsor
- NTC srl
Infertility, Infertility, Female
Assessing Ketorolac (Toradol) at Oocyte Retrieval
To determine if a nonsteroidal anti-inflammatory drug (NSAID), Ketorolac (Toradol), can improve pain control and decrease narcotic use after undergoing egg retrieval.
- Conditions
- Infertility, Infertility, Female, Oocyte Retrieval, Postoperative Pain
- Trial name
- Alleviate (NCT06026553)
- Testing
- Ketorolac (Toradol)
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Surgery
Topical 0.4% Ketorolac and Vitreoretinal Surgery
To determine whether use of topical 0.4% ketorolac has any effect on pupil size during vitreoretinal surgery.
- Trial name
- NCT00576329
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Pain
Dosing of Ketorolac in the Emergency Department
The optimal dose of ketorolac in the Emergency Department setting is no clear. We will compare 3 doses to determine the optimal dose.
- Trial name
- NCT03464461
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- University of Missouri-Columbia
Recurrent Acute Tonsillitis
KITS Study -Ketorolac In Tonsillectomy Surgery: a Double Blinded, Randomized Clinical Trial
Our group wishes to test the novel hypothesis that intraoperative use of ketorolac in pediatric patients undergoing tonsillectomy reduces post-operative nausea and vomiting, postoperative pain scores, subsequent narcotic use, and…
- Trial name
- KITS (NCT01498796)
- Testing
- Ketorolac, Normal Saline
- Where
- Canada
- Volunteers
- 121 people
- Sponsor
- University of Alberta
Diabetic Retinopathy, Macular Edema
Topic Antiinflammatory Therapy Added to Selective Photocoagulation in Macular Edema
The purpose of this study is to determine the efficacy of ocular topic antiinflammatory therapy (sodic nepafenac at 0.1% or ketorolac at 0.5%) to treat center point thickness secondary to selective photocoagulation in diabetics…
- Trial name
- NCT00900887
- Testing
- Ketorolac, Nepafenac, Polietilenglicol 400, propilenglicol
- Where
- Mexico
- Volunteers
- 84 people
- Sponsor
- Hospital Juarez de Mexico
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Acute Pain
Intranasal Ketorolac for Postsurgical Pain in Dental Implant Patients
The surgical placement of dental implants is presently a common procedure performed by oral surgeons, periodontists, and general dentists.
- Trial name
- NCT01490931
- Testing
- Ketorolac Nasal Spray
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Hersh, Elliot V., DMD, MS, PhD
Pain Management
Ketorolac at Lower Doses for Analgesic Pain Control in ICU: A Pilot Feasibility Study
Opiates are commonly used to control pain in critically ill patients in the ICU. However, increased rates of opiate use in hospital may lead to increased prescription-based opiate dependence after leaving the ICU.
- Trial name
- KETOROLAC-ICU (NCT06819956)
- Testing
- Ketorolac
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Pain
SPRIX in 0 to 11 Year-Old Patients Undergoing Open Surgical Procedures
The purpose of this study is to evaluate the pharmacokinetics and safety of postoperative administration of SPRIX in pediatric patients (ages 0-11) undergoing open surgical procedures.
- Trial name
- NCT02102516
- Testing
- SPRIX(intranasal ketorolac tromethamine)
- Where
- 4 sites in Poland
- Volunteers
- 45 people
- Sponsor
- Egalet Ltd
Nephrectomy, Laparoscopic Donor Nephrectomy
Intravenous Ketorolac for Postoperative Pain in Laparoscopic Donor Nephrectomy
The purpose of this study is to determine whether continuous intravenous ketorolac infusion reduces pain in patients who are having laparoscopic surgery to donate a kidney.
- Trial name
- NCT00765232
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Mayo Clinic
Post-operative Pain, Post-partum Pain
Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
To evaluate the efficacy of increased ketorolac in reducing opioid use after cesarean section.
- Conditions
- Post-operative Pain, Post-partum Pain, Cesarean Section Complications
- Trial name
- NCT03678675
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Early-stage Breast Cancer, Estrogen-receptor-positive Breast Cancer
Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)
Out of all proportion to its short duration, the perioperative period is critical in determining the long-term outcome of cancer.
- Trial name
- KePreSt (NCT06150898)
- Testing
- Prospective data and sample collection, Ketorolac 10 Mg Oral Tablet, Pregabalin 75mg
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Jules Bordet Institute
Headache
A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache
This randomized, double-blind trial will compare the clinical efficacy of IV acetaminophen to that of IV ketorolac as adjuncts to standard therapy (prochlorperazine and diphenhydramine) in the treatment of patients presenting to…
- Trial name
- NCT03472872
- Testing
- Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Corewell Health South