Clinical trials: Ketosis, Diabetic
Type 2 Diabetes
Combination of Sulfonylureas and Insulin Glargine Outpatient Therapy for Unstable Diabetes and Impending DKA
The purpose of this study is to compare two simple and safe emergency department discharge therapy for Type 2 Diabetes patients with severe hyperglycemia and with no indications for inpatient admission.
- Trial name
- NCT00732524
- Testing
- Glipizide, Glipizide and Glargine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cook County Health
Pediatric Disorder
Ecg & Echo Changes in Children With DKA
Diabetic ketoacidosis (DKA) is an important complication of childhood diabetes mellitus and the most frequent diabetes-related cause of death in children.
- Trial name
- NCT03454152
- Volunteers
- 60 people
- Sponsor
- Assiut University
Diabetic Ketoacidosis
Diabetic Ketoacidosis: Brain Morphology and Cognition
The purpose of this study is to assess brain and memory changes in patients with uncontrolled diabetes (a condition called diabetic ketoacidosis (DKA))
- Trial name
- DKA-Cog (NCT02443415)
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetic Ketoacidosis
Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis
The goal of this blinded, cluster cross-over, randomised controlled trial is to determine whether fluid therapy with Plasma-Lyte® 148 increases the number of days alive and days out of hospital to day-28 compared to 0.9% sodium…
- Trial name
- BEST-DKA (NCT05752279)
- Testing
- Plasma-Lyte 148, 0.9% sodium chloride
- Where
- 21 sites in Australia
- Volunteers
- 547 people
- Sponsor
- The George Institute
Diabetic Ketoacidosis
Two Bag System for Diabetic Ketoacidosis
This is a study investigating the best way to treat diabetic ketoacidosis (DKA) with intravenous (IV) fluids in the hospital. The purpose of this study is to determine whether the "two bag" system of administering IV fluids for…
- Trial name
- 2BagDKA (NCT03660189)
- Testing
- Two bag system
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- MetroHealth Medical Center
Type 1 Diabetes, Covid19
Hospitalized Children and Adolescent Patients With Type 1 Diabetes During the COVID-19 Pandemic in Egypt
Although reports showed that children with well controlled diabetes do not appear to have increased risk of infection with SARS-CoV-2, however data are scarce regarding the extent to which clinical and demographic data of patient…
- Trial name
- NCT04536285
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 1
The Real-World Control-IQ Glycemic Control and Quality of Life Study in Type 1 Diabetes in France
This post-market surveillance study is primarily designed to demonstrate the ongoing safety of the Control-IQ system, the ongoing performance of glycemic control and quality of life with Control-IQ system use, and the rate of use…
- Trial name
- RECORD-IQ (NCT07211126)
- Testing
- t:slim X2 insulin pump with Control-IQ technology (Control-IQ System)
- Where
- 25 sites in France
- Volunteers
- 350 people
- Sponsor
- Tandem Diabetes Care, Inc.
Correlation Between Serum Chloride and Anion Gap in DKA Patients
Correlation Between Serum Chloride and Anion Gap Levels in DKA Patients
2.2 Aim(s) of the Research (50 words max): 1. To examine the description and correlation of changes in the serum chloride levels and changes in the anion gap values before and after fluid resuscitation in patients with DKA and to…
- Trial name
- NCT05598866
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Mervat Mokhles Fathi Sayed
AKI in Diabetic Ketoacidosis
Prevalence of Acute Kidney Injury in Patients With Diabetic Ketoacidosis
prevalence of acute kidney injury in patients with diabetic ketoacidosis
- Trial name
- NCT05508490
- Testing
- renal chemistry, serum electrolyte,
- Volunteers
- 100 people
- Sponsor
- Assiut University
Type 1 Diabetes
Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?
Previous data from our clinical trial has demonstrated that the combination of dapagliflozin plus pioglitazone cause robust decrease in the plasma glucose concentration without significant increase in plasma ketone concentration…
- Trial name
- NCT06922656
- Testing
- Dapagliflozin (DAPA), Pioglitazone 45 mg
- Where
- 3 sites in Kuwait, Qatar and 1 more
- Volunteers
- 60 people
- Sponsor
- Dasman Diabetes Institute
Diabetic Ketoacidosis, Diabetes Mellitus
Leukocyte Glucose Index and Severity of Diabetic Ketoacidosis
This prospective cohort study aims to evaluate the relationship between admission Leukocyte Glucose Index (LGI) and the severity of diabetic ketoacidosis, as well as the presence of diabetic microvascular complications, among…
- Trial name
- NCT07821814
- Volunteers
- 120 people
- Sponsor
- Assiut University
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Ketosis Prone Diabetes
Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity
The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.
- Trial name
- NCT06699810
- Testing
- Continuous Glucose Monitoring, Insulin
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Diabetes
A Computer-Based Simulation of DKA Management
A 2-by-2 factorial cluster randomized controlled trial was performed to: 1) Compare the effects of supervised (coached) versus unsupervised (no coach) administration of the DKA simulator on trainees' knowledge of DKA management…
- Trial name
- DKA (NCT02799563)
- Testing
- Coach, Preselected number of cases, Coach, Self-selected number of cases, No coach, Preselected number of cases
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type 1 Diabetes Mellitus
Dapagliflozin Plus Pioglitazone in T1DM
Purpose: To examine the effect of addition of combination therapy with dapagliflozin plus pioglitazone to insulin on glucose control and plasma ketone concentration in patients with type 1 diabetes (T1DM) Research Design: 120…
- Trial name
- NCT03878459
- Testing
- Pioglitazone 45 mg
- Where
- 3 sites in United States, Israel and 1 more
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetic Keto-acidosis
Fluid Administration in Ketoacidosis (DRINK)
Management of severe diabetic ketoacidosis is based on insulin therapy, correction of metabolic disorders and fluid resuscitation.
- Trial name
- DRINK (NCT06541535)
- Testing
- Fluid resuscitation with isotonic saline only, Fluid resuscitation with Ringer Lactate
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Diabetes Type 2, DKA
Diabetic Ketoacidosis From New SGLT2i: Can Genomics Estimate Risk
Sodium glucose co-transporter 2 (SGLT2) inhibitors have revolutionized care for people living with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Type 2, DKA, Diabetic Ketoacidosis
- Trial name
- DaNGER (NCT05402579)
- Testing
- Genomic analysis
- Where
- 2 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Mount Sinai Hospital, Canada
Diabetic Ketoacidosis
Use of Blood Ketone Meters to Improve Ambulance Hyperglycaemia Care
In this KARMA2 feasibility study the investigators are testing whether ambulance staff can reliably and safely identify patients at high risk of diabetic ketoacidosis using blood ketone meters and start fluid (saline) therapy…
- Trial name
- KARMA2 (NCT04940897)
- Testing
- Use of CareSens ketone meter
- Where
- United Kingdom
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- East of England Ambulance Service NHS Trust
Diabetic Ketoacidosis, Type 1 Diabetes
Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
- Conditions
- Diabetic Ketoacidosis, Type 1 Diabetes, Type 2 Diabetes
- Trial name
- NCT04567225
- Testing
- Early Glargine, Late Glargine, IV insulin infusion
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- The Cleveland Clinic