Clinical trials: Ketosis, Diabetic
Diabetic Children
Prevalence and Factors Associated With Pancreatic Enzyme Elevations Among Diabetic Children
Acute pancreatitis was reported as a DKA associated complication. The true incidence and clinical significance of pancreatitis in children with DKA is unclear.
- Trial name
- NCT05392166
- Testing
- blood glucose, blood gases, serum electrolytes, HbA1c, complete blood count and serum creatinine. Serum calcium, serum amylase, serum lipase and serum triglycerides , abdominal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Diabetic Ketoacidosis
Effectiveness of Subcutaneous Glargine On The Time To Closure of The Anion Gap in Patients Presenting to the Emergency Department With Diabetic Keto-acidosis
To determine if co-administration of subcutaneous (SQ)Insulin glargine in combination with intravenous (IV) insulin decreases the time to resolution of ketoacidosis and requirement for ICU admission compared to IV insulin with…
- Trial name
- GT-COG (NCT02006342)
- Testing
- Insulin Glargine, Regular Insulin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes
Fluid Resuscitation for Pediatric Diabetic Ketoacidosis
Randomized trial to determine if the volume of fluid administration in pediatric patients with DKA impacts the rate of normalization of serum bicarbonate, pH as well as the length of treatment
- Trial name
- NCT01701557
- Testing
- slow fluid rate, fast fluid rate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Ketosis, Keto Acidosis
Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'
Rationale: During perioperative period, prolonged starvation, surgical stress, acute complications (e.g. infection) and medication changes all promote ketone generation, therefore increasing the risk of ketoacidosis.
- Conditions
- Ketosis, Keto Acidosis, Ketoses, Metabolic, Ketosis, Diabetic
- Trial name
- DKAP (NCT05225467)
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetic Ketoacidosis
REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis
A number of scientific papers have been published on the efficacy and safety of adding REAMBERIN® (meglumin sodium succinate), a 1.5% infusion solution, to standard therapy for patients with diabetic ketoacidosis (DKA), which…
- Trial name
- NCT06955416
- Testing
- Reamberin
- Where
- 3 sites in Russia
- Volunteers
- 312 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Chronic Kidney Diseases
Outcome of Glargine Insulin in Renal Impairment Patients With Diabetic Ketoacidosis
The study aims to compare between the use of continuous low dose insulin infusion versus co-administration of low dose continuous insulin infusion and early subcutaneous insulin glargine in diabetic ketoacidosis patients with…
- Trial name
- NCT05219942
- Testing
- Glargine, normal saline
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Diabetic Ketoacidosis
Children with Diabetic Ketoacidosis
In the present work we aim to 1. Response to therapy, During the management of DKA, acid base status, glycemia, and serum electrolytes are measured frequently to monitor the efficacy of treatment, detect complications of DKA and…
- Trial name
- NCT06599203
- Volunteers
- 130 people
- Sponsor
- Assiut University
Diabetic Ketoacidosis, Acute Kidney Injury
Risk Factors and Outcomes of Acute Kidney Injury in Patients With Diabetic Ketoacidosis at Sohag University Hospital.
Diabetic ketoacidosis (DKA), a severe complication of diabetes mellitus (DM), is the leading cause of hospitalization, morbidity and mortality in patients with DM (1).
- Trial name
- NCT05867797
- Volunteers
- 100 people
- Sponsor
- Sohag University
Treatment Diabetic Ketoacidosis, Electrolyte Balance Effects
Electrolyte Balance Effects of Sterofundin Versus Normal Saline in Diabetic Ketoacidosis
The goal of this prospective single centered randomized control trial is to compare the electrolyte balance effects between Sterofundin and Normal Saline in Diabetic Ketoacidosis patients.
- Trial name
- NCT06399510
- Testing
- Sterofundin fluid therapy
- Where
- Malaysia
- Volunteers
- 58 people
- Sponsor
- Universiti Sains Malaysia
Evaluate Ketogenic Stress
An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes
The study investigations include evaluation of the acute effects of a single dose of dapagliflozin (10mg), exenatide (5µg), a combination of exenatide and dapagliflozin or placebo under insulinopenic condition and the long term…
- Trial name
- NCT02962492
- Testing
- Exenatide/Exenatide extended release, Dapagliflozin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University at Buffalo
Diabetic Ketoacidosis, Uncontrolled Type 1 Diabetes Mellitus
DKA Optic Ultrasound
Diabetic ketoacidosis (DKA) is a complication of type 1, or "insulin-dependent," diabetes (T1DM) and is defined by a high blood glucose level (over 200 mg/dL) coupled with severe acidosis.
- Trial name
- DKA Optic US (NCT02130180)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Ketosis, Diabetic
Exogenous Ketones in People With Type 1 Diabetes
The aim of this pilot study is to investigate the metabolic effects of exogenous ketone ester food supplements, by assessing the change in blood acid-base balance, and the level of blood beta-hydroxy-butyrate in people with type…
- Trial name
- NCT04487678
- Testing
- Ketone ester supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitius
Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 As Biomarkers of AKI in Children With DKA
Type 1 diabetes mellitus (T1DM) is a common, chronic, metabolic disorder that has significant consequences for physical and emotional development .
- Trial name
- AKI (NCT06032325)
- Testing
- Neutrophil Gelatinase and Kidney Injury Molecule-1
- Volunteers
- 48 people
- Sponsor
- Assiut University
Diabetes Mellitus, Diabetes Mellitus, Type 1
RT-CGM in Young Adults at Risk of DKA
Pilot study to evaluate the effect of real time continuous glucose monitoring (RT-CGM) on young-adults with insulin-treated diabetes, who are defined as high risk due to suboptimal HbA1c (blood glucose control) or a history of…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- YODA (NCT04039763)
- Testing
- Dexcom G6, Self monitoring of blood glucose
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2
The BRIGHT Study (Device Name: HALO System)
The purpose of the BRIGHT study is to evaluate safety and performance of the HALO SYSTEM in subjects with diabetes mellitus. The primary objectives of this clinical investigation are 1) the evaluation of sensor's performance by…
- Conditions
- Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Diabetes Mellitus, Ketoacidosis, Diabetic
- Trial name
- NCT07745998
- Testing
- The HALO System
- Volunteers
- 12 people
- Sponsor
- Indigo Diabetes NV
Diabetic Ketoacidosis
Clinical and Laboratory Parameters Associated With Different Degrees of Dehydration Among Children With Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) is a common acute complication of type 1 diabetes mellitus (T1DM). DKA is characterized by hyperglycemia, metabolic acidosis, increased levels of ketone bodies in blood and urine.
- Trial name
- NCT05383404
- Testing
- blood and urine samples
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Diabetes Mellitus, Type 2
Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan
Every lunar year, during the month of Ramadan, Muslims abstain from food and drink between dawn and nightfall. People with type 2 diabetes who fast during Ramadan are at an increased risk of acute glycemic complications.
- Trial name
- NCT04237493
- Testing
- Metformin and Glimepiride (Low Dosage), Metformin and Vildagliptin (Low Dosage), Metformin and Insulin Glargine U100 (Low Dosage)
- Where
- Jordan
- Volunteers
- 687 people
- Sponsor
- University of Jordan
Diabetes, Ketoacidosis
Two Bag System for Hydration in Diabetes
This is a randomized controlled trial comparing the time needed to get the conditions to space hourly controls to controls every 4 hours, using the one bag system versus the two bags system, in the initial treatment of children…
- Trial name
- NCT01631929
- Testing
- One bag, Two bags
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Diabetes Mellitus, Diabetic Ketoacidosis
Starvation in the Treatment of Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are common, but serious metabolic disorders are often encountered in intensive care.
- Trial name
- NCT06186245
- Testing
- Early feeding with an oral diet
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Diabetic Ketoacidosis Children
Plasma Copeptin Levels in Children With Diabetic Ketoacidosis
Children with diabetic ketoacidosis risk neurological complications such as cerebral edema with high morbidity. To prevent cerebral edema, it is essential to control correction of hypovolemia, hyperglycemia and natremia.
- Trial name
- COPACD (NCT02994316)
- Testing
- Copeptine dosage in children with diabetic ketoacidosis at diagnosis
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier