Clinical trials: Ketosis, Diabetic
Diabetic Ketoacidosis
Impact of Clinical Nursing Guideline on Outcomes of Children With Diabetic Ketoacidosis.
Diabetic ketoacidosis (DKA) is a serious and potentially life-threatening complication of diabetes mellitus in children and requires timely and structured management to prevent morbidity and mortality.
- Trial name
- PED-DKA (NCT07467616)
- Testing
- Evidence-Based Nursing Guideline for Children with Diabetic Ketoacidosos
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Hawler Medical University
Diabetic Ketoacidosis
Cerebral Edema in Pediatric Diabetic Ketoacidosis
The purpose of this trial is to compare two different rates of fluid administration during diabetic ketoacidosis (DKA) treatment in children to determine which fluid administration rate is more beneficial for brain metabolism and…
- Trial name
- NCT00629707
- Testing
- intravenous fluid treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Diabetic Ketoacidosis
Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis
This is a randomized, double-blind, placebo-controlled trial to determine if administration of intravenous thiamine will lead to quicker resolution of acidosis in patients admitted to the hospital with diabetic ketoacidosis.
- Trial name
- NCT03717896
- Testing
- 200mg IV thiamine in 50mL 0.9% saline
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Beth Israel Deaconess Medical Center
Diabetic Ketoacidosis
Role of CBC as a Prognostic Marker for DKA Patients
1. To evaluate that change of platelet-to-lymphocyte Ratio affect the duration of hospital stay and mortality rate of DKA patients 2.
- Trial name
- NCT05666895
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Diabetes Mellitus, Type 1
Effects of Micronutrient (Chromium) Supplementation on Diabetes
6-8% of USA population has diabetes. Intensive blood glucose control dramatically reduces the devastating complications that result from poorly controlled diabetes.
- Trial name
- NCT01709123
- Testing
- chromium niacinate
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Diabetic Ketoacidosis
Use of Insulin Glargine to Treat Diabetic Ketoacidosis
The purpose of this study is to determine the effects of the addition of insulin glargine during the early phase of moderate to severe Diabetic Ketoacidosis (DKA) in children.
- Trial name
- NCT00179127
- Testing
- glargine, saline
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Ketosis, Diabetic
StatStrip Glucose/Ketone Meter System Ketone Evaluation
The Nova StatStrip Glucose / Ketone Meter System is a fast, simple, whole blood system that can be used to quantify both glucose and ketones using two distinct test strips.
- Trial name
- NCT05118061
- Testing
- Ketone
- Where
- 3 sites in United States, Germany
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Nova Biomedical
Ketosis Prone Diabetes, Diabetic Ketoacidosis
Ketosis Prone Diabetes in African-Americans
Over 50% of obese African-Americans (AA) presenting with newly diagnosed, severe hyperglycemia and/or unprovoked diabetic ketoacidosis (DKA) display clinical, metabolic, and immunogenetic features of type 2 diabetes.
- Conditions
- Ketosis Prone Diabetes, Diabetic Ketoacidosis, Severe Hyperglycemia
- Trial name
- NCT00426413
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetic Ketoacidosis
Double Blinded Randomized Control Trial of Types of IVF in Children With DKA
Objectives: Intravenous (IV) fluid administration is a fundamental component of diabetic ketoacidosis (DKA) treatment. Normal saline (NS), the most common IV fluid used in DKA management, contains more chloride than human blood.
- Trial name
- NCT03066440
- Testing
- Normal saline, Lactated Ringers
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- State University of New York at Buffalo
DKA
Early Administration of Insulin Glargine in Patients With Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) is a medical emergency that is associated with significant morbidity and mortality for both patients with type I and type II diabetes.
- Trial name
- NCT06007508
- Testing
- Insulin Glargine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- HealthPartners Institute
Diabetes Mellitus, Type 1
The Impact of Different CSII and CGM Systems on Different Clinical Outcome Variables in Children and Adolescents With Type 1 Diabetes. An Observational Study Form the Norwegian Childhood Diabetes Registry (NCDR)
To examine the effect of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) on metabolic control, in a large population-based nationwide observational study under real life conditions.
- Trial name
- NCT04201171
- Testing
- CSII and CGM
- Volunteers
- 2,749 people
- Sponsor
- Helse Fonna
Diabetes Mellitus, Type 1, Diabetes Complications
Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes
Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mortality as their white counterparts.
- Trial name
- NCT06236607
- Testing
- Device specific training, Study clinician/educator visit
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Boston Medical Center
Metabolic Acidosis, Diabetic Ketoacidosis
Diabetic Ketoacidosis Diagnosis and Management
This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
- Conditions
- Metabolic Acidosis, Diabetic Ketoacidosis, Brain Edema
- Trial name
- NCT06327737
- Testing
- Capnography
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Akdeniz University
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Diabetic Ketoacidosis
Compliance With American Diabetes Association Treatment Guidelines for Adult Ketoacidosis
At this time, Saint Mary's Medical Center is currently in the process of implementing a standardized diabetic ketoacidosis (DKA) protocol.
- Trial name
- NCT00589680
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Marshall University
Metabolic Ketoacidosis, Ketoacidemia
0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis
Severe diabetic ketoacidosis (DKA) is a potentially serious complication of diabetes mellitus. The treatment regimen is based on insulin and rehydration. The choice of rehydration solution is a question that remains open.
- Conditions
- Metabolic Ketoacidosis, Ketoacidemia, Acetonemia, Acetonuria
- Trial name
- NCT05808972
- Testing
- Sodium chloride 0.9% (SC), Ringer lactate (RL)
- Where
- Tunisia
- Volunteers
- 92 people
- Sponsor
- Tunis University
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Sepsis, Acute Kidney Injury
Identifying Risk Factors for Developing AKI in Sepsis
A study to evaluate the prevalence of Acute Kidney Injury (AKI) in patients with Diabetic Ketoacidosis (DKA) and sepsis using data collected prospectively to a patient registry.
- Conditions
- Sepsis, Acute Kidney Injury, Diabetic Ketoacidosis
- Trial name
- NCT04825639
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Cardiff and Vale University Health Board
Diabetic Ketoacidosis
Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications
Diabetic ketoacidosis (DKA), a frequent complication of diabetes, is the consequence of a profound insulin deficiency responsible for osmotic polyuria and thus major losses of water, glucose, sodium and potassium as well as a…
- Trial name
- LOSTINDIAB (NCT05443802)
- Testing
- Insulin 0.05 IU/kg/h, Insulin 0.10 IU/kg/h
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes
Evaluating the Occurrence of DKA in People With Type I Diabetes
This study will evaluate the occurrences of Diabetes-related Ketoacidosis (DKA) in adult and pediatric individuals living with Type I diabetes while managing diabetes with Abbott's Continuous Monitoring Systems.
- Trial name
- NCT07739342
- Testing
- Abbott Continuous Dual Glucose Ketone Monitoring System
- Where
- 7 sites in New Zealand
- Volunteers
- 1,200 people
- Sponsor
- Abbott Diabetes Care