Clinical trials: Ketosis, Metabolic
Diabetes Mellitus, Type 2, Urosepsis
Safety of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Among Patients With Type 2 Diabetes
The purpose of this study is to compare the risk of serious adverse events associated with the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in comparison with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors among…
- Conditions
- Diabetes Mellitus, Type 2, Urosepsis, Diabetic Ketoacidosis, Lower Extremity Amputation
- Trial name
- NCT04017221
- Testing
- Sodium-glucose cotransporter 2 (SGLT2) inhibitors, Dipeptidyl peptidase-4 (DPP-4) inhibitors, Other treatment combinations
- Where
- Canada
- Volunteers
- 1,249,636 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Starvation, Caesarean Section
Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study
The primary aim of this randomised control trial is to assess the impact of pre-operative carbohydrate loading on the incidence of urinary ketone bodies when compared to standard care in elective caesarean section.
- Trial name
- NCT03220997
- Testing
- Vitaflow Preload
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Epilepsy
Internet Administration of the Modified Atkins Diet for Adults With Intractable Epilepsy
This is a prospective, open-label (no control or blind) study to continue to determine whether the modified Atkins diet reduces seizures, creates ketosis, and is well tolerated in adults (not children) with epilepsy.
- Trial name
- NCT00436631
- Testing
- Dietary management of seizures
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus
EtCO2 for Monitoring and Predicting Severity of DKA in Pediatric Emergency, Doha, Qatar.
Metabolic acidosis is one of the important and life-threatening pathophysiological changes in DKA and its monitoring is essential.
- Trial name
- NCT04121572
- Testing
- Nasal cannula capnography
- Where
- Qatar
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Gastroenteritis, Dehydration
Study Investigating the Use of Intravenous Fluids With Dextrose for Dehydrated Children
Infants and young children often become infected with gastroenteritis leading to vomiting and diarrhea. This can lead to dehydration, one of the most common complaints in the Pediatric Emergency Department.
- Trial name
- NCT01343758
- Testing
- 5% dextrose in normal saline
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Ketosis, Blood Hormones
The Impact of Ketone Monoester Intake on Post-exercise Hormonal Responses After Resistance Exercise in Young Males
This study investigates how orally ingested exogenous ketone monoester supplements affect circulating hormone concentrations in healthy young adult males after a single session of resistance exercise.
- Conditions
- Ketosis, Blood Hormones, Testing Effect of Intervention, Resistance Exercise
- Trial name
- NCT06683547
- Testing
- Ketone Monoester (KET), Resistance Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- McGill University
Behavior
Exogenous Ketones and Behavior
The study will examine the effect of exogenous ketone ester on behavior and metabolism using Virtual Reality and computerizes behavioral tasks.
- Trial name
- ExoKet (NCT06515717)
- Testing
- ketone ester
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Ketosis, Ketonemia
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects
This is a randomized, placebo-controlled, double-blinded crossover design. Fifteen healthy subjects will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid.
- Trial name
- KETO (NCT05980858)
- Testing
- Beta-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Diabetes Mellitus, Diabetic Ketoacidosis
Starvation in the Treatment of Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are common, but serious metabolic disorders are often encountered in intensive care.
- Trial name
- NCT06186245
- Testing
- Early feeding with an oral diet
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Alzheimer's Disease
Tricaprilin in Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability and effectiveness of tricaprilin administered once a day for ninety days in subjects with mild to moderate, probable Alzheimer's disease.
- Trial name
- NCT00142805
- Testing
- Tricaprilin
- Where
- 25 sites in United States
- Volunteers
- 152 people
- Sponsor
- Cerecin
Diabetic Ketoacidosis, Postoperative Care
Postoperative Euglycemic Ketoacidosis Frequency in Sodium-Glucose Cotransporter-2 Inhibitor Users
The goal of this observational study is to determine the frequency of postoperative euglycemic diabetic ketoacidosis (EDKA) in patients receiving Sodium- Glucose Cotransporter-2 (SGLT-2) inhibitors.
- Trial name
- SGLT-2I (NCT07127406)
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Ketosis, Exercise Performance
Ketone Supplementation and Exercise Performance
The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).
- Conditions
- Ketosis, Exercise Performance, Ketoses, Metabolic
- Trial name
- NCT03954665
- Testing
- 10 km time trial, 30s Wingate, Ketone
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Muscle Wasting, Protein Intake
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat…
- Conditions
- Muscle Wasting, Protein Intake, Ketosis, Caloric Restriction
- Trial name
- NCT04744142
- Testing
- Ketone supplementation, Increased protein intake
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Pulmonary Hypertension, Ketonemia
Ketones for Pulmonary Hypertension - Effects on Hemodynamics
In the present study, patients with idiopathic pulmonary hypertension (IPAH) and chronic thromboembolic pulmonary hypertenion will be investigated in a randomized cross-over design with ketone infusions and placebo.
- Trial name
- KEPAH (NCT04615754)
- Testing
- Hyperketonemia - use of ketone (3-OHB) infusion
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Ketosis, Type 2 Diabetes
Exogenous Ketones in Type 2 Diabetes
Exogenous ketone supplements are proposed to have glucose-lowering potential, provide an alternative fuel for the brain and to enhance cognitive function.
- Trial name
- NCT04194450
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of British Columbia
Ketones, Dietary Supplements
Exogenous Ketones and Glucose Tolerance
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source.
- Trial name
- NCT03461068
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Diabetic Ketoacidosis
Diabetic Ketoacidosis: Brain Morphology and Cognition
The purpose of this study is to assess brain and memory changes in patients with uncontrolled diabetes (a condition called diabetic ketoacidosis (DKA))
- Trial name
- DKA-Cog (NCT02443415)
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Alzheimer Disease, Glucose Metabolism
Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.
The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence.
- Trial name
- KetoHome (NCT05642052)
- Testing
- low carb diet, Regular diet
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketosis
Variations in Ketone Metabolism
This outcome of this study will elucidate how the phenotype of the individual modulates the KE metabolic effect. Most studies of KE have been in homogenous populations, usually young, male athletes.
- Trial name
- STAK-VKM (NCT05924295)
- Testing
- Ketone Supplement, Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale, Blood Draw
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ohio State University